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Biomedical subjects

E Nathan

Publications and source records attributed to E Nathan.

At least 37 records · Page 2Linked to original sources
PubMed1984

Persistently increased intestinal fraction of alkaline phosphatase.

Persistent elevation of the intestinal fraction of the alkaline phosphatase (API) as an isolated finding has to our knowledge not been reported previously. It was found in a boy followed during a period of 5.5 years. The only symptom was transient periodic fatigue observed at home, but not apparent during hospitalization. His blood type was O, RH+, Le (a-, b+) and he was a secretor of H-substance, which may be associated with rising API activity after fat-loading. In this case API was unchanged after fat-loading. Neither intestinal nor liver diseases were found, and no other cause for the elevated phosphatase activity could be demonstrated.

Alkaline Phosphatase↗
PubMed1983

Long-term treatment of children with sustained-release theophylline.

After one year of sustained-release theophylline (SRT) treatment, 19 children with severe perennial asthma participated in a 6-week, placebo-controlled, randomized, double-blind cross-over study. The severity of their asthma was evaluated before SRT-treatment (pre-period) and one year later, both during the theophylline period and the placebo period of the double-blind study. Compared with the pre-period, all observed parameters, except the number of extra bronchodilators required, were statistically significantly improved in the placebo period of the double-blind trial performed after one year. In addition, except for peak expiratory flow measured at home and the number of acute attacks, all parameters were significantly improved during the theophylline period when compared with placebo treatment. During this study, mean serum theophylline level was 13.3 mg/l (range 7.8-19.4 mg/l). The results show that theophylline remains efficient after one year's administration. The much better control of the children's asthma following one year of treatment emphasizes the need for regular re-evaluation of children receiving continuous prophylactic treatment.

Asthma↗
PubMed1981

Serum concentrations of theophylline in children treated with two daily doses of a sustained-release theophylline preparation.

Over a 3-month period 22 asthmatic children were treated with a sustained-release theophylline preparation (Nuelin Retard, Riker) in twice-daily doses. During the first 2 weeks of treatment slight side-effects were observed in 14 children. Over the remaining 10-week period only four children experienced minor-side-effects. Serum theophylline levels 4 hours after tablet administration were measured three times and serum levels just before tablet administration were measured once during the observation period. The average difference between the serum levels of theophylline just before tablet administration and the corresponding serum value 4 hours afterwards was 4.2 microgram/ml. The serum values 4 hours after tablet administration showed an insignificant fall throughout the period and patient compliance was assessed as good. When the average requirements of theophylline in mg/kg found by Wyatt et al. (15) (Table 2) were used as initial doses, few dosage adjustments were necessary and no serum values were greater than 26.2 microgram/ml, but in order to avoid serum levels above 20 microgram/ml initial doses should be decreased about 10% and final adjustment made with the aid of serum theophylline measurement under steady state conditions. In children, Nuelin Retard given in two daily doses is capable of maintaining a constant therapeutic serum concentration for the whole 24-hour period.

Adolescent↗
PubMed1980

Transient hyperphosphatasemia of infancy.

Striking transient increases in serum alkaline phosphatase in 6 infants are reported. Isoenzymes were studied in 3 infants and increased activity was found in bone as well as in liver fractions. Repeated serum determinations demonstrated a duration of about 11 weeks with a peak serum value in the 6th week. The etiology is unknown but an infectious cause is discussed. The condition may be rather frequent but gives no obvious symptoms. It is important to know this condition to avoid unnecessary diagnostic procedures.

Alkaline Phosphatase↗
PubMed1980

Dialysis encephalopathy in a non-dialysed uraemic boy treated with aluminium hydroxide orally.

Brain aluminium concentration has been found significantly higher in patients dying with dialysis encephalopathy than in uraemic patients without this syndrome, and it has previously been reported only in haemodialysed patients. We report a case of high brain aluminium concentration in a uraemic boy showing symptoms of severe encephalopathy. He was never dialysed but only treated with aluminium hydroxide orally. Baluarte reported corresponding symptoms in nondialysed uraemic children, but brain aluminium concentrations were not reported. His patients as well as our had very high levels of parathormone which may play a role in the resorption and distribution of aluminium. Aluminium preparations should be avoided in children with renal failure.

Administration, Oral↗
PubMed1980

Scanning electron microscopy of the responses of postmenopausal endometrium to treatment with estriol and estriolprogesterone.

Seven postmenopausal women are given estriol orally in a daily dose of 1 mg x 2 or 5 mg x 2 for 14 or 28 days and 2 women were sequentially treated with 5 mg x 2 of estriol orally for 21 days, with the addition of 0.2 g x 2 of progesterone rectally in the last 7 days. Three women served as controls. Scanning electron microscopy revealed that the former treatment with estriol was sufficient to produce an estrogen response in the non-ciliated uterine epithelial cells, which developed many long microvilli, sometimes arranged in tufts. The sequential treatment with initial estriol priming followed by estriol and progesterone combined resulted in a slight secretory transformation of the uterine epithelium, observed as an increase in size and number of the apical protrusions of the cells.

Aged↗