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Biomedical subjects

E Nakano

Publications and source records attributed to E Nakano.

At least 163 records · Page 9Linked to original sources
PubMed1987

[Clinical experience of enoxacin in the treatment of nongonococcal urethritis].

Enoxacin (ENX) is a new derivative of pyridonecarboxylic acid and has a broad spectrum antibacterial activity. In this study, the effects of ENX on nongonococcal urethritis (NGU) were examined in 20 patients. ENX was administered orally 3 times a day at a daily dose of 600 mg for 2-23 days. Before treatment, Chlamydia trachomatis was isolated from urethral epithelium in 5 of the 20 patients. Of the 18 patients evaluated in this clinical trial, 15 (83%) responded well, and ENX was effective in 3 of the 5 Chlamydia positive cases and in 12 of the 13 Chlamydia-negative patients. As adverse reactions, headache was observed in one case and numbness of limbs in another case. No abnormality induced by ENX was recognized in laboratory findings. It is concluded that ENX is a useful drug in the treatment of patients with NGU, particularly in whom Chlamydia trachomatis is not isolated.

Adolescent↗
PubMed1987

Primary repair of interrupted aortic arch and severe aortic stenosis in neonates.

Two infants, aged 36 days old (Case 1) and 18 days old (Case 2) with interrupted aortic arch types B and A, respectively, and with severe aortic stenosis, were successfully operated on by use of pulsatile cardiopulmonary bypass. The great arteries were normally related in Case 1 and were transposed in Case 2. Repair involved the following procedure: ligation of the patent ductus arteriosus, restoration of aortic continuity with an 8 mm polytetrafluoroethylene graft, placement of an internal patch to tunnel all left ventricular blood from the left ventricle through the ventricular septal defect into the pulmonary artery in Case 1 and patch closure of the ventricular septal defect in Case 2, transection of the main pulmonary artery, anastomosis between the proximal pulmonary artery and the ascending aorta, and interposition of a valved conduit between the right ventricle and the distal pulmonary artery. The operative field could be approached easily through a median sternotomy. Postoperative cardiac catheterization revealed satisfactory anatomical and hemodynamic results in both cases.

Aorta↗
PubMed1987

[Percutaneous nephrolithotripsy: a report of 50 cases].

Fifty patients with renal (33 patients), renal and ureteral (4 patients) and ureteral (13 patients) stones were treated by percutaneous nephrolithotripsy (PNL) between November 15, 1984 and December 14, 1985. Complete stone removal was achieved in 39 cases (78%). Four of the 11 cases of incomplete stone removal were among the first 5 cases we treated. We have not experienced any severe complications in our 50 cases. The cause of the unsuccessful attempts, complications and other factors of PNL are briefly discussed.

Adult↗
PubMed1987

[A case of serous papillary adenocarcinoma of the ovary initially suspected to be a uretero-vaginal fistula].

A case of serous papillary adenocarcinoma of the ovary initially suspected to be an uretero-vaginal fistula is reported. The patient was a 57-year-old female with the complaint of urinary leakage from the vagina. Because she had undergone a supravaginal hysterectomy for myoma uteri 10 years earlier, a uretero-vaginal fistula was initially suspected. However, the fistula was not recognized from the findings of excretory and retrograde pyelographies. Chemical analysis of the vaginal discharge was similar to serum rather than urine. Gynecological examination showed the presence of an ovarian tumor. Right oophorectomy and extirpation of remaining cervix combined with partial resection of rectum was performed. From the pathological finding that the tumor consisted of serous papillary adenocarcinoma, the vaginal discharge was confirmed to originate from the tumor. Ovarian tumors with serous discharge from the vagina seem to be very rare.

Cystadenocarcinoma↗
PubMed1986

A large calcium-binding protein associated with the larval spicules of the sea urchin embryo.

A tissue-specific, high molecular weight, calcium-binding protein from the sea urchin embryo is described. This protein, designated as CBP 180, has a molecular weight of 180,000 under reducing conditions, and is extractable with 1% Triton X-100. It accumulates rapidly during development, starting roughly at the onset of spiculogenesis. When embryos are cultured in the presence of inhibitors of spicule formation, such as tunicamycin and zinc ions, accumulation of CBP180 is depressed or stopped. By immunofluorescence technique and by using an antibody specifically generated against this protein, CBP180 is mainly localized in primary mesenchyme cells and spicular syncytium of the pluteus larva. Little or none is detectable in ectoderm, endoderm or blastocoelar extracellular matrix. These results suggest that the protein is involved in calcium sequestration in the differentiation of larval spicules.

Animals↗
PubMed1986

Solitary late recurrence of renal cell carcinoma.

Solitary late recurrence is an unpredictable behavior pattern of renal cell carcinoma. We describe a patient with recurrence at the cranial bone 10 years after surgical management and another with recurrence at the sacral bone 13 years after treatment with radiotherapy and alpha-interferon. Both patients have been followed satisfactorily for 9 months. Unpredictable behavior of renal cell carcinoma makes lifelong followup of patients necessary. If a solitary recurrence is detected operative management definitely should be considered depending on the site of recurrence.

Carcinoma, Renal Cell↗
PubMed1986

Distribution of fibronectin, microtubules and microfilaments in the melanophore of the medaka, Oryzias latipes.

Distributions of fibronectin, microtubules and microfilaments in the melanophore of the medaka, Oryzias latipes, were studied using immunofluorescence. We found fluorescent fibers of fibronectin running from the central region to the periphery of the melanophore, but patterns differed depending on whether melanophores had been treated with methanol. Fibrous structures were present in methanol-treated melanophores, whereas only diffuse fluorescence was seen in untreated ones. These fibrous structures, thought to be microtubules, were arranged radially. Actin fibers also showed a radial arrangement, but were not as well organized. In addition, granules with actin immunofluorescence were present.

Actin Cytoskeleton↗
PubMed1986

[A 46, XX true hermaphrodite with H-Y antigen].

A 23-year-old man was admitted to Osaka University Hospital with complaints of breast enlargement and defect of bilateral scrotal content. A gonad-like organ could be palpable at bilateral inguinal area and pubic hair was a female escutcheon in spite of complete male phenotype for both external genitalia and posterior urethra by retrograde urethrogram. Decreased serum value of testosterone and increased the serum value of estradiol and progesterone were found by endocrinological evaluation. Karyotype derived from skin fibroblast and peripheral lymphocyte was 46, XX and H-Y antigen was detected. Exploratory laparotomy disclosed uterus and bilateral ovotestis with epididymis, seminal vesicle and Fallopian tube. The patient received gonadectomy, hysterectomy and insertion of testicular prosthesis.

Adult↗