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Biomedical subjects

E N Shliakhov

Publications and source records attributed to E N Shliakhov.

18 recordsLinked to original sources
PubMed1991

[Experimental imutiol stimulation of the primary immunological response to tetanus anatoxin].

The data on the influence of imuthiol on humoral and cell-mediated immunity developing after immunization against tetanus are presented. Experiments were made on 166 guinea pigs with the use of imuthiol in doses of 25 and 125 mg/kg and tetanus toxoid in doses of 1.5 and 6.0 BU/kg. The dynamic observation of the animals lasted 30 days. The data of the passive hemagglutination test and the neutralization test indicated that imuthiol had considerable influence on the formation of humoral immunity. The results of skin reactions with tetanin, in vitro cell reactions, as well as resistance tests, showed that imuthiol exerted influence on delayed hypersensitivity, the mechanisms of cell-mediated resistance and survival after challenge. The data on the influence of imuthiol could be registered even at early stages after immunization, the immunostimulating action of the preparation reaching its maximum with tetanus toxoid used in a dose of 6.0 BU/kg and imuthiol, in a dose of 125 mg/kg.

Animals↗
PubMed1980

[Optimization of anthrax vaccination on the basis of rational classification of populated sites].

The improved epidemiological situation requires the proper revision of the tactics used in vaccinating the population against anthrax. The important task lies in the optimization of the immunoprophylaxis of the rural population in accordance with the epizootologic situation in a given locality. To ensure correct orientation in choosing the groups of population to be vaccinated a rational classification of inhabited localities is proposed: they are classified as anthrax-free and anthrax-affected, and the latter fall into manifest, conditionally manifest, nonmanifest and unclassified. The use of the cartographic method based on this classification is recommended. The proposed vaccination tactics will allow to reduce the number of persons covered by immunoprophylaxis by 70-75%, making this coverage more exact, and to improve the epidemiological effectiveness of vaccination.

Agricultural Workers' Diseases↗
PubMed1980

[Mechanism of action of levamisole on cells of the mononuclear phagocytizing system].

The levamisole effect on the phagocytic capacity of macrophages and their membrane permeability was studied in A and CBA mice. It was shown that both in vivo and in vitro, levamisole treatment of peritoneal and splenic macrophages resulted in the diminution of antigen uptake and slowing down of its clearance as compared with control animals. The exposure to levamisole led to the enhanced membrane permeability and the decreased total cathepsin activity in the peritoneal cells and in their lysosomes.

Animals↗
PubMed1977

[Immunological properties of the preparations of the anti-anthrax antigen].

The results of examination of immunological properties of the preparations of anthrax protective antigen on laboratory animals (guinea pigs) confirmed the efficacy of using the lactic-peptone medium for obtaining the anthrax protective antigen. Incubation for 18 hours at 37 degrees C of the strain-producer (STI-1) and a double immunization scheme with the antigen obtained proved to be the most rational conditions for inducing the immunological response in the vaccinated laboratory animals. Three fractions of the anthrax protective antigen obtained possessed weaker immunobiological properties than the whole preparation of this antigen.

Animals↗