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Biomedical subjects

E N Morozova

Publications and source records attributed to E N Morozova.

7 recordsLinked to original sources
PubMed1997

[Toxic properties of recombinant tumor necrosis factor].

Toxic properties of recombinant human tumor necrosis factor (TNF-beta) were studied on noninbred albino mice. In the maximum tolerable doses the preparation induced a decrease in the body weight and temperature of the animals as well as development of glyco- and leukopenic reactions and damage of the internal organ structures. The preparation effects were observed early after the exposure and were mainly reversible. The most TNF-beta sensitive organs were the liver, lungs, adrenal gland, thymus and spleen. The major link in the pathological process development under the effect of the TNF-beta toxic doses was likely increased intravascular blood coagulability evident from a marked procoagulant activity of the preparation.

Animals↗
PubMed1988

[Pharmacological analysis of the effect of natural double-helical nucleic acids on the detoxifying function of the liver].

The effect of interferon inductors i.e. double stranded RNAs from S. cerevisiae and phage F6 on the liver detoxicating function was studied on noninbred albino mice. The liver detoxicating function was tested by duration of hexenal sleep. It was shown that intraperitoneal administration of the yeast and phage RNAs in doses of 1/5 LD50 for three times led to increasing of the narcotic sleep duration in the animals by 65 and 207 per cent, respectively. The effect was of the dose-dependent nature. The doses not inducing reliable inhibition of hexenal metabolism were equal to 1/10 LD50 for the yeast dsRNA and 1/27 LD50 for the phage dsRNA. The inhibitory effect of the dsRNAs was retained for 2-3 days after discontinuation of the drug use. When the dsRNAs were administered simultaneously with nembutal, an inductor of the liver microsomal enzymes, the dsRNAs eliminated its inducing effect. Simultaneous administration of alpha-tocopherol lowered the dsRNA effect on hexenal metabolism. The findings suggested that the dsRNA inhibitory effect on the liver detoxicating function was grounded on the mechanisms associated with inhibition of syntheses and activation of lipid peroxidation specific of the monooxygenase system under the action of the dsRNAs.

Animals↗
PubMed1986

[Toxic properties of the double-stranded RNA of virus-like particles from Saccharomyces cerevisiae killer yeasts].

The toxic properties of dsRNA isolated from S. cerevisiae were studied on noninbred albino mice. The preparation was administered intraperitoneally. The lots of the yeast dsRNA consisted of highly and moderately toxic compounds. The toxicity level was directly associated with the content of the dsRNA in the preparation. Administration of the preparation in doses equal to the maximum tolerance dose and 1/5 of LD50 had no significant effect on the motor activity, temperature and weight of the animals. However, it induced marked morphological impairments in the gastrointestinal tract, liver and kidneys and pronounced shifts in the hematological indices. 1/50 of LD50 had no significant effect on the physiological, hematological and morphological indices of the organs. No capacity for the yeast dsRNA cumulation in the host was observed.

Animals↗
PubMed1983

[Morphofunctional analysis of the chief (peptic) glandulocytes in the stomach of hibernating rodents].

Ultrastructure of the chief gastric gland cells has been studied in the ground squirrel (Cytellus erythrogenys Brandt) at various seasons of the year. When the ground squirrel is in the active state, the cells studied do not differ from those in other animals. During winter hibernation, their activity is inhibited. During first days of awakening, the activity of the chief cells increases; the protein-synthesizing apparatus, the Golgi complex become activated, secreating granules accumulate. At the same time, the greatest number of the destroing cellular elements and discharge of the residual bodies out of the activizing cells are observed. Restoration of the normal structure in the chief cells is completed by the end of the second week. No signs demonstrating transformation of additional cells into the chief ones are revealed. Non-differentiated cells in the ground squirrel fundal glands are widely distributed along the whole length of the glandular cervix and occur even in the upper parts of its body.

Animals↗
PubMed1982

[Analysis of the component constitution and substrate specificity of a fibrinolytic preparation from the fungus Flammulina velutipes].

The degree of heterogeneity of the proteolytic complex from the fungus Flammulina velutipes was studied by gel chromatography and analytical isoelectrofocusing. The fibrinolytic, thrombolytic, caseinolytic, endo- and aminopeptidase activities of the enzyme complex were compared to those of Aspergillus terricola and Streptomyces griseus proteinases. The proteolytic complex under study consists of at least two proteinases with pI 6.1 and 7.1, which possess fibrinolytic, thrombolytic and endopeptidase activities and of two aminopeptidases with pI 5.5 and 6.05. All these activities are inhibited by metal-chelating reagents. A low caseinolytic activity of the complex suggests that it can successfully be employed as a therapeutic agent.

Agaricales↗