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Biomedical subjects

E N Glick

Publications and source records attributed to E N Glick.

16 recordsLinked to original sources

Reflex sympathetic dystrophy (algoneurodystrophy): temperature studies in the upper limb.

The temperature response of the hands to mild cold stress (20 degrees C for one minute) has been measured in 20 normal subjects, 20 patients with reflex sympathetic dystrophy (RSD) and 10 patients with chronic upper limb pain (CULP) of uncertain origin. The results of RSD and CULP groups were significantly (p less than 0.05) different from normal but were indistinguishable. For each patient, 11 variables obtained from the thermal stress test were compared with the normal range. Ten of the RSD group and seven of the CULP group had four or more abnormal variables and were considered to have a thermoregulatory abnormality. The thermal stress test is useful in the objective assessment of RSD. It is non-invasive, patient acceptable and reproducible.

Adult↗

A multi-centre study of sulindac versus naproxen in the treatment of elderly osteoarthritic patients.

Ninety-five geriatric patients with osteoarthritis of the hip and/or knee were entered into an open parallel group study of sulindac (400 mg/day) and naproxen (500 mg/day), both given in twice-daily regimens. Patients received the drugs for 12 weeks. Both drugs produced improvements in the patients' overall condition. There were no statistically significant differences between the effects of the two drugs. Overall, both drugs proved beneficial and well tolerated.

Aged↗

A clinical Trial of Tofranil in osteo-arthritis.

Animal experiments and uncontrolled clinical experience indicate that imipramine should relieve pain or enhance the effect of analgesics in osteoarthritis. A double-blind crossover trial using Tofranil 25 mg three times daily and matching placebo has, therefore, been designed and initiated.

Acetaminophen↗

Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.

Four patients with rheumatoid arthritis (R.A.) developed myasthenia gravis after taking penicillamine. In one patient withdrawal of the drug was followed by spontaneous remission of the myasthenia, and in two the dose of anticholinesterase was subsequently reduced. In the fourth patient continuing penicillamine treatment was associated with increasingly severe myasthenic features, but on withdrawal of the drug these resolved. As myasthenia gravis rarely complicates R.A. its onset in these patients shortly after the start of penicillamine treatment suggested that penicillamine may have precipitated this condition.

Adult↗

Ice therapy.

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Analgesia↗