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Biomedical subjects

E N Gerasimova

Publications and source records attributed to E N Gerasimova.

At least 19 recordsLinked to original sources
PubMed1990

[Possible relationship between polyunsaturated fatty acids and signs of left ventricle hypertrophy].

In aborigines from the costal and continental areas of Chukotka who differ in dietary polyunsaturated fatty acid (PFA) n-3 intake, specific features of the composition of fatty acids in cell membranes were revealed in a model of erythrocytes: the costal inhabitants showed a higher proportion of PFA n-3 mainly through eicosapentaenic acid and lower proportion of major PFA n-6. With this, plasma lipoprotein lipids in whose composition the acids transported to the cell membranes displayed the similar regularities in changes in fatty acid composition. Only a far larger portion of eicosapentaenic acid in the cell membranes from the costal inhabitants than from the continental inhabitants was associated with greater mass of the left ventricular myocardium. It was concluded that transport of lipids containing high PFA n-3 in the composition of lipoproteins to the cell membranes caused an increase of the acids in them and, evidently, a change in physicochemical and, therefore, functional properties of cells.

Adult↗
PubMed1988

[Fatty acids of the omega-3 line in the erythrocytes of Chukchi with myocardial hypertrophy].

A study was made of the fatty acid composition of erythrocytes in the Chukchi aged 30 to 59 with myocardial hypertrophy and in controls. In erythrocytes of the Chukchi the percentage of polyunsaturated fatty acids of omega-3 series including eicosapentaenoic acid was increased (C 20:5), and the percentage of linoleic acid and arachidonic acid was decreased (C 18:2 and C 20:4, respectively) as compared to similar indices of erythrocytes in Muscovites. Myocardial hypertrophy was diagnosed in the Chukchi in whom the percentage C 20:5 in erythrocytes was higher and exceeded that in PL. It was assumed that changes in the fatty acid composition of cell membranes played certain part in disorder of their function and the development of myocardial hypertrophy in the Chukchi.

Adult↗
PubMed1988

[Changes in phospholipid composition of high density lipoproteins in children as a possible precursor of the development of ischemic heart disease].

The proportion of apoprotein-AI (apo-AI) phospholipids (PL) and HDLP phospholipid spectrum were determined in addition to principal coronary risk factors; cholesterol (CS), triglycerides (TG) and high-density lipoprotein (HDLP) CS, in high-risk children, whose parents had survived myocardial infarction at a young age, and also in children with vegetovascular dystonia and a control group. It is demonstrated that children with relatively low percentage of lecithin in HDLP, in the absence of changes in CS, TG, apo-B and apo-AI, and HDLP CS, could be found in all the examined groups, and were particularly numerous in the high-risk group. Correlations coefficients for the HDLP PL percentage in the father-child, mother-child and father-mother pairs were estimated, revealing a positive correlation with respect to lecithin in these pairs, an evidence of the contribution of the general familial environment to the variability of the parameter in question in the examined groups. Different correlations were demonstrated between lecithin/sphingomyelin and lecithin/kephalin ratios in boys and girls from the control and high-risk groups.

Adolescent↗
PubMed1986

[Transport of the fatty acids composing the phosphatidylcholines and sphingomyelins of the low- and very high-density lipoproteins in the blood plasma in myocardial hypertrophy].

A comparative analysis of the fatty acid composition of phosphatidylcholines (PC) and sphingomyelins (SP) of lipoproteins (LP) of low and very low density was performed in the blood plasma of Eskimos (indigenous population of the Chukot Peninsula) in myocardial hypertrophy and in the control group as well as in the control group of Muscovites. Some characteristic features of the fatty acid composition of low density LP PC and SP were revealed in Eskimos in myocardial hypertrophy. The role of changes in the transport of fatty acids of low density LP PC and SP of the blood plasma in the myocyte membrane liquidity as well as in the synthesis of biologically active prostacyclin revealed in myocardial hypertrophy was discussed.

Adult↗
PubMed1985

[Changes in the indices of plasma lipoprotein and apolipoprotein spectra in patients with myocardial infarct and unstable stenocardia over the course of a year's observation].

Over the period of one year the authors examined the changes in the parameters of the plasma spectrum of lipoproteins and apolipoproteins in 46 patients with acute macrofocal myocardial infarction and 35 patients with labile angina. In six cases variations in these parameters were studied in the course of unstable angina and in the post-infarction period. It was established that myocardial infarction induced specific alterations in the plasma lipoprotein system not only in the immediate post-infarction period but also at more long-term periods. Myocardial infarction causes deep and prolonged disorders in the apolipoprotein system which may contribute to the progression of atherosclerotic damage to the coronary arteries.

Adult↗
PubMed1984

[Serum apolipoproteins A-1 and B in young males with a history of myocardial infarction].

The content of the protein-lipid components of lipoproteins of individual classes was studied in 87 coronary heart disease patients surviving myocardial infarction under 40 years of age. All the patients lived in Sverdlovsk. The control group was made up of 49 age-matched males without any symptoms of CHD. CHD patients aged 30-39 years showed a number of differences as compared to healthy men; these included elevated plasma levels of cholesterol, triglycerides and low-density lipoprotein cholesterol as well as an increase in the apoprotein B levels and the apo-B/apo-A1 ratio. In a group of CHD patients aged 20-29 years enhanced plasma concentrations of apo-B and an increase in the apo-B/apo-A1 ratio, the latter approaching 1 were the only change in the lipoprotein system as against control.

Adult↗
PubMed1984

[Disruption of the cholesterol-transport function of lipoproteins in the blood plasma of patients with ischemic heart disease].

A ratio cholesterol esters/apo B in very low and low density lipoproteins (VLDL and LDL), characterizing their cholesterol-transport function, as well as a ratio cholesterol esters/apo A-I in high density lipoproteins (HDL) HDL2 and HDL3, demonstrating the loading of cholesterol per unit of their main protein, were studied in 16 patients with ischemic heart disease accompanied by coronary atherosclerosis documented by angiography and in 36 healthy men. In patients with coronary atherosclerosis and low level of HDL cholesterol, particles of atherogenic lipoproteins were overloaded with cholesterol esters, while the ratio cholesterol esters/apo A-I was decreased in HDL2 and HDL3 as compared with controls. These alterations might be related to an increase in efficiency of cholesterol esters transport from HDL into VLDL and LDL as a result of dissimilar transformations in chemical and structural characteristics of surface monolayer of VLDL and HDL particles studied earlier.

Adult↗
PubMed1983

[Arterial pressure and concentrations of blood lipids in the populations of Moscow and Leningrad].

Epidemiological investigation of two randomized groups of men born in 1916-1935 (3908 men in Moscow, 3907 in Leningrad) has shown that in both populations there is a direct relationship between the arterial pressure (AP) and the level of total cholesterol (CS), triglycerides (TG) and cholesterol lipoproteids of high density (CS-LPHD) in blood plasma. A strong correlation between the level of the systolic arterial pressure (SAP) and age has been established. Age variations of the lipid levels were insignificant. The total CS, TG, SAP levels and the diastolic AP increase with the growth of the relative body weight, while the CS-LPHD level decreases. In the group engaged in manual labour the total CS and TG levels are simultaneously lowered and those of CS-LPHD and SAP elevated. There is a direct relationship between the level of CS-LPHD, AP and alcohol intake. Smoking somewhat lowers the level of CS-LPHD and AP. The direct relationship between AP and the level of CS-LPHD remains after complex analysis including all the factors studied.

Adult↗
PubMed1983

[Changes in blood plasma lipid and apolipoprotein content in the course of acute myocardial infarction].

Patterns of changes in blood plasma lipids and apolipoproteins were examined in 16 patients with acute large-focal myocardial infarction. Six of those were investigated during unstable angina pectoris. Lipoproteins responsible for cholesterol transport to tissues (apo-beta-containing lipoproteins) and its outflow (apo-A-I-containing lipoproteins) were shown to undergo a variety of metabolic changes in the course of myocardial infarction. Possible prognostic implications of patterns of post-infarction changes in lipoprotein and apolipoprotein spectrum are discussed with respect to predicting further development of atherosclerosis.

Acute Disease↗
PubMed1983

[Phospholipid content of subfractions of high density lipoproteins in women with angiographically documented coronary arteriosclerosis].

The concentration of high density lipoproteins (HDL) and the phospholipid content of HDL2 and HDL3 were estimated in the plasma of 23 women with coronary heart disease (CHD) and in the control group of 38 healthy women. The concentration of HDL cholesterol (HDL-C) was significantly reduced in patients with CHD in comparison with the control group. There was also a significant decrease of the per cent content of lecithin and an increased content of sphingomyelin, especially in HDL2 subfraction. It is concluded that the reduction of HDL-C content is accompanied by changes in the phospholipid content of HDL that may result in reduction of cholesterol-acceptor properties of these particles.

Adult↗
PubMed1983

[Plasma levels of testosterone and lipid-protein components of high density lipoproteins and their subclasses in the native population of the Chukotka national autonomic region].

In a representative aboriginal male Chukchi population, relationships were examined between major lipid-protein components of high-density lipoproteins (HDLP) and their subclasses (HDLP2 and HDLP3) and physiological plasma testosterone patterns. A single-trend correlation was established between cholesterol and phospholipids of each of the HDLP subclasses, and plasma triglycerides and testosterone. Apo-AI for each of the HDLP subclasses showed different trends of correlation with both triglycerides and normal range of testosterone. The findings are indicative of different patterns in the formation of HDLP2 and HDLP3 particles.

Adult↗
PubMed1982

Differential study of phosphatidylcholine and sphingomyelin in human high-density lipoproteins with lipid-specific fluorescent probes.

Modified phosphatidylcholine and sphingomyelin containing an anthryl end group attached to one of the fatty acyl chains were used as fluorescent probes in an investigation of the molecular organization of human high-density lipoproteins (HDL). Monolayer experiments and NMR measurements showed the anthryl-labeled lipids to mimic closely the corresponding host phospholipids, the fluorophores being located near to the terminal CH3 groups of the fatty acid residues. The above fluorescent phospholipid probes made it possible for the first time to study differentially the behaviour of phosphatidylcholine and sphingomyelin in HDL. The probes were shown to interact in a different way with the apoprotein tryptophans and to be non-randomly distributed at the surface of the globules. The probable sphingomyelin binding site of apolipoprotein A-I was defined. Evidence was obtained suggesting the existence in high-density lipoproteins of two slowly exchanging phospholipid pools: one strongly bound to apoproteins, and the other free or loosely bound. Fluorescence parameters characterizing the fluidity of HDL phospholipids and their interaction with the apoprotein tryptophans were found to correlate with the HDL cholesterol level. The possible significance of the obtained results for a better understanding of the relation of high-density lipoproteins to coronary heart diseases is discussed.

Energy Transfer↗
PubMed1982

Flow cytofluorometric study of lipoprotein interactions with cultured endothelial cells.

Accumulation of rhodamine B isothyocyanate-conjugated low density lipoproteins (R-LDL) in cultured endothelial cells from human umbilical cord was studied with a fluorescence activated cell sorter. R-LDL uptake was blocked at 0 degrees C, inhibited by addition of excess of nonlabeled low density lipoprotein, high density lipoprotein-2 or high density lipoprotein-3. High density lipoprotein-2 was about twice as effective in inhibition of R-LDL uptake as high density lipoprotein-3. Endothelial cells that formed a contact-inhibited monolayer lost the ability to incorporate R-LDL via a receptor-mediated pathway. Using R-LDL, it was possible to distinguish cells with different levels of R-LDL incorporation.

Cell Separation↗
PubMed1981

[Phospholipid characteristics of the HDLP2 and HDLP3 composition in dysalphalipoproteinemia].

There has been determined the phospholipid composition in HDLP2 and HDLP3 obtained from the blood plasma of males with different cholesterol (CS) level of HDLP. An increase in CS of HDLP is shown to be associated with the increase in a percentage of phosphatidylcholine, a proportion of phosphatidylcholine/sphingomyelin and a reduction of the percentage of sphingomyelin (mainly in HDLP2) and to a lesser extent--in HDLP3. A direct correlation has been established between the level of CS of HDLP obtained from the blood plasma of males living in 3 different geographical zones of the USSR and the indices of the phospholipid composition of HDLP2. Changes found in the phospholipid composition of HDLP3 in dysalphalipoproteidemia are associated with a difference in the triglyceride level of the blood plasma.

Adult↗