Search PubMed⌕ Search

Biomedical subjects

E N Burgova

Publications and source records attributed to E N Burgova.

11 recordsLinked to original sources
PubMedDate not supplied

[Nitric oxide production in pregnancy and experimental acute kidney insufficiency].

Nitric oxide production in organs of pregnant mice (liver, kidney, placenta) was measured using specifical NO traps, Fe-dithiocarbamate complexes (Fe-DETC) forming with NO paramagnetic mononitrosyl iron complexes with DETC (MNIC-DETC), detected by EPR method (-196 degrees C). The amount of NO formed increased in dependence of the pregnancy period (from the first to the third trimesters). Addition of NO-synthase substrate, L-arginine, insignificantly influenced endogenous NO production. However, endogenous NO amount sharply decreased at experimental acute renal failure.

Acute Kidney Injury↗
PubMedDate not supplied

[Paramagnetic form of ribonucleotide reductase in human tissues].

The paramagnetic form of ribonucleotide reductase was detected by ESR method in human cervix tissues, especially in tumor ones. The magnetic relaxation rate was proved to be slower for this form than for that in normal animal tissues having a high level of proliferative activity or in Ehrlich tumor cells studied before.

Electron Spin Resonance Spectroscopy↗
PubMedDate not supplied

[Effect of the hyperbaric oxygenation of animals and man on mitochondrial function in their tissues (based on EPR study data)].

The ration of differential intensities of EPR signal of free endogenous radicals of semiquinone type and iron-sulfur proteins recorded at the temperature of liquid nitrogen in tissues (R index) is proposed as a criterion for estimation of changes in the functional state of mitochondria in human and animal tissues treated with hyperbaric oxygenation (HBO). The increase in R value was observed in hearts of intact mice and rabbits treated with HBO in near-toxic doses. This indicates a shift in mitochondria redox state towards oxidation. The above effect was not observed in mitochondria from intact zone of myocardium in animals with experimental infarction, and the numbers of mitochondria in the tissue increased after HBO. HBO treatment of women with pathological pregnancy leads to the decrease in R value for placental mitochondria.

Animals↗
PubMedDate not supplied

[Effect of hyperbaric oxygenation on paramagnetic centers in the rabbit myocardium during experimental myocardial infarction].

Changes in paramagnetic centres (PC) concentration in rabbit's myocardial muscle were studied under experimental myocardial infarction during 168 hours by means of ESR-spectroscopy. PC characterized by ESR signal with g = 3.0 was found. It was shown that hyperbaric oxygenation did not affect PC content in the infarction zone, and resulted in an increase of PC concentration with g = 1.94 and g = 2.0 in the intact myocardial zone.

Animals↗
PubMedDate not supplied

[Increased levels of transferrin in the rabbit heart muscle in experimental myocardial infarction].

Concentration of transferrin was distinctly increased in the infarction zone of heart muscle of rabbits with experimental myocardium infarction within 24 hrs and 168 hrs after coronary occlusion. Under conditions of cell lysis apotransferrin appears to bind free iron in rabbit heart muscle. The data obtained suggest that apotransferrin may serve as a screening agent of free iron, while caeruloplasmin is able to exhibit the superoxide dismutase activity.

Animals↗
PubMedDate not supplied

[Hydrophobic and hydrophilic complexes of Fe2+ with dithiocarbamate derivatives as a nitric oxide trap in mice].

It has been shown by using EPR method that hydrophobic complexes Fe(2+)-diethyldithiocarbamate (DETC) act more efficiently as a selective traps of nitric oxide (NO) in mice organisms than hydrophilic complexes Fe(2+)-N-methyl-D-glutamyldithiocarbamate (MGD). This difference seemed to be due to higher stability of paramagnetic mononitrosyl iron complexes with DETC (MNIC-DETC) formed in vivo in animal tissues in a result of NO binding with Fe(2+)-DETC complexes. Analogous complexes MNIC-MGD appeared a blood were oxidized to diamagnetic, EPR silent form. The latter was also detected in mouse urine especially for animals which were pretreated with bacterial lipopolysaccharide inducing increased NO generation in mice organisms. Nitrogen dioxide or peroxynitrite formed endogenous NO were suggested to be the agents which oxidized MNIC-MGD by reversible way in mice organisms.

Animals↗