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Biomedical subjects

E N Beckman

Publications and source records attributed to E N Beckman.

30 records · Page 2Linked to original sources
PubMed1983

Progressive myelofibrosis in agnogenic myeloid metaplasia.

Progression of myelofibrosis in agnogenic myeloid metaplasia (AMM) has only rarely been documented because of the paucity of patients with sequential bone marrow examinations. At our institution, 27 patients with AMM underwent marrow examinations, separated by at least six months. Of the 20 patients who did not have maximal myelofibrosis shown by the original biopsy, 18 displayed temporal progression of the process; 11 of them had an increase of two or more grades using the Bauermeister scale. The grade remained constant in the remaining two patients. Several cases of a decreased degree of fibrosis or variation of grade in concomitant specimens showed that fibrosis may not proceed at an identical rate throughout the marrow and that the degree may vary with location.

Adult↗
PubMed1982

Fibrous hematopoietic tumors arising in agnogenic myeloid metaplasia.

Tumors of extramedullary hematopoiesis occasionally occur in long-standing cases of agnogenic myeloid metaplasia (AMM) and resemble hypercellular marrow in a connective tissue stroma. Rarely, this type of tumor mass is markedly fibrous and may pose diagnostic difficulty, especially when there is only limited knowledge of a patient's clinical history. The authors reports two cases of AMM with such a fibrous hematopoietic tumor, occurring in one patient as a pelvic mass and in another as lymphadenopathy and skin nodules. A review of the literature revealed that fibrous hematopoietic tumors associated with AMM arise predominantly in the retroperitoneum, pelvis, mesentery, and pleura. Features helpful in establishing the diagnosis include longstanding AMM, megakaryocytes and other hematopoietic cells within the fibrous tissue, and lack of atypia in the fibrous tissue. Current evidence suggests that the fibrous component of the masses is reactive and possibly related to stimulation of fibroblasts by humoral substance released from platelets.

Female↗
PubMed1982

Gastric xanthoma: histologic similarity to signet ring cell carcinoma.

Gastric xanthomas (GX) are pale yellow nodules or plaques, usually less than 3 mm in size, in the gastric mucosa. They are frequently found in groups, most often along the lesser curvature and pyloric regions. They consist of liquid-laden histiocytes in the lamina propria occasionally extending into the submucosa. There is no correlation between GX and hypercholesterolemia. The lesion is of little significance, except as it may be misdiagnosed as carcinoma. We present two cases of GX, one initially thought histologically to be a signet ring cell carcinoma. With the paucity of reports of GX in the medical literature and the potential for incorrect diagnosis, we emphasize the importance of recognition and accurate histologic diagnosis of GX.

Adenocarcinoma, Mucinous↗
PubMed1981

Histopathology of marine vibrio wound infections.

Although marine vibrio wound infections and septicemia are being reported with increasing frequency, description of the histopathologic changes has been scanty. The histologic alterations in three patients with primary marine vibrio wound infections are presented. The lesions are characterized by intense acute cellulitis of the subcutis with much tissue destruction and extension into the adjacent dermis. The superficial dermis is devitalized and lacks an inflammatory cellular infiltrate. Subepidermal noninflammatory bullae are formed. Many organisms are seen both within the areas of intense acute inflammation and in devitalized areas. Organisms and inflammation are especially oriented around vessels, with associated acute vasculitis. It is concluded that the morphologic picture in marine vibrio wound infections is nonspecific yet characteristic.

Adult↗
PubMed1981

Ovarian enterobiasis--a proposed pathogenesis.

An Enterobius vermicularis within the parenchyma of the ovary is a rare phenomenon. We present a case and propose that the gravid female, after wandering from perianal skin into the vagina and then through the female genital passages, arrived at the ovary and entered a recently ruptured graafian follicle.

Adult↗
PubMed1981

Oral ulceration mimicking midline (nonhealing) granuloma.

Destructive facial or oropharyngeal lesions, or both, require aggressive diagnostic inquiry. Early differentiation of clinically similar lesions is vitally important but often difficult. Both cases presented in this report were initially diagnosed as having midline (nonhealing) granuloma. Further diagnostic efforts were required to establish a definitive diagnosis.

Aged↗
PubMed1981

Azoospermia: diagnosis and management.

By using a detailed history and physical examination, endocrinologic studies, and, in some cases, testicular biopsy, we assign azoospermic men to three pathogenic groups: pretesticular, testicular, and posttesticular. This and further subclassification allow physicians to provide prognostic information. A few patients will have lesions amenable to surgical correction, or endocrinologic abnormalities that can be treated by replacement therapy or, as in the case of prolactin elevation, by surgery, irradiation, or bromocriptine therapy. Patients afflicted with irreversible sterility should be advised to accept the diagnosis and consider other pathways to parenthood, such as adoption or artificial insemination.

Humans↗
PubMed1978

Cushing's syndrome and acute lymphoblastic leukemia.

Cushing's disease developed in a 5-year-old girl with acute lymphoblastic leukemia 18 months after her last therapeutic exposure to adrenal glucocorticosteroids. Obesity, hyperpigmentation, striae, osteoporosis, and hirsutism were accompanied by elevated levels of plasma cortisol. These showed no diurnal fluctuation and they were not suppressed by dexamethasone. At autopsy, the adrenal glands were enlarged and the pituitary gland showed increased numbers of basophils of the adrenocorticotropic hormone (ACTH)/melanocyte-stimulating hormone secreting type. Leukemic infiltrates in brain tissue were prominent in the hypothalamus and in the limbic system. It is postulated that the destructive leukemic infiltrate of the limbic system removed a restraining influence on pituitary function, with basophilic hyperplasia, ACTH hypersecretion, adrenocortical hypertrophy, and clinical Cushing's disease the consequences.

Adrenal Gland Neoplasms↗