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Biomedical subjects

E Munthe

Publications and source records attributed to E Munthe.

87 records · Page 5Linked to original sources
PubMed1971

[Polymyositis].

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Dermatomyositis↗
PubMedDate not supplied

Penicillamine in rheumatic diseases: a prospective study of tolerance and efficacy.

Tolerance to D-penicillamine was studied prospectively over an 8-yr period in 318 patients with inflammatory rheumatic disorders. Adverse reactions, observed in 76% of patients, required permanent withdrawals in only 47% of the 318. Withdrawals could be reduced by lowering dosage and making increments extremely slowly. In 207 rheumatoid arthritis patients who had received gold thiomalate, adverse reactions to D-penicillamine were fewer than with the gold and, less often, caused permanent withdrawals. Of 164 nonresponders to gold thiomalate, 53% responded to D-penicillamine. Only 10% of nonresponders to D-penicillamine responded to gold thiomalate.

Arthritis, Rheumatoid↗
PubMedDate not supplied

D-penicillamine-induced increase in intracellular glutathione correlating to clinical response in rheumatoid arthritis.

Measurement of glutathione (GSH) in consecutive blood samples from patients with rheumatoid arthritis (RA) revealed, in good responders to D-penicillamine, a 20% to 35% increase in erythrocyte-GSH (E-GSH) levels after 2 to 8 wk of treatment. Usually this rise predicted a clinical response some wk later. Nonresponders to D-penicillamine who did not show an increase in E-GSH could be converted to responders by receiving L-cysteine. E-GSH rose--prior to the clinical response--by up to 50% of pretreatment values. In RA patients with spontaneous changes in disease activity, E-GSH tended to decrease during relapses and increase before remissions.

Adrenal Cortex Hormones↗