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Biomedical subjects

E Mukhtar

Publications and source records attributed to E Mukhtar.

6 recordsLinked to original sources
PubMed1986

Endoscopic retrograde cholangiopancreatography in Sudanese diabetics.

Endoscopic retrograde cholangiopancreatography (ERCP) was performed in 40 Sudanese patients with diabetes mellitus. 25 were insulin-dependent and 15 were noninsulin-dependent. ERCP was normal in all the patients with insulin-dependent diabetes. Two patients with noninsulin-dependent diabetes had pancreatographic changes compatible with minimal-change pancreatitis. Diabetes mellitus in Sudan unlike in other tropical countries is not associated with structural changes in the exocrine pancreas.

Adolescent↗
PubMed1986

Water goitrogens and endemic goitre in the Sudan.

The main cause of endemic goitre in the Sudan is dietary iodine deficiency. Water samples from four areas [Kass, Kosti, Wad Medani and Omdurman] two of which are known for endemic goitre did not appear to have any goitrogenic effect in our preliminary experiment using porcine thyroid follicle cell preparations.

Animals↗
PubMed1985

A new focus of endemic goitre in the Sudan.

The prevalence of goitre in the town of Kosti, Central Sudan and the city of Khartoum was investigated on account of the increasing number of goitrous patients in the wards and out-patient clinics of Khartoum Hospital coming from the county of Kosti. The frequency of goitre among 7173 school children from Kosti was 74.8%, and was higher in girls (82.1%) than in boys (67.3%). The frequency among 7075 school-children of Khartoum was 17.5%. The mean urinary iodine excretion in subjects from Kosti was significantly lower (41.8 micrograms/g creatinine) than in those from Khartoum (83.6 micrograms/g creatinine) (p less than 0.001). The water content of iodine in Kosti was low (0.1 micrograms/1). There were no significant differences in the mean serum concentrations of triiodothyronine, thyroxine and thyroid stimulating hormone (TSH) between goitrous and non-goitrous subjects from Kosti. The mean serum level of TSH was higher in goitrous subjects from Kosti (5.2 +/- 1.4 mU/1) than in non-goitrous subjects from Khartoum. These data indicate a high prevalence of goitre in Central Sudan, mainly attributable to iodine deficiency, a fact which has not previously been recognized. Recent environmental goitrogenic factors might have modified the adaptation of the thyroid gland and promoted the occurrence of goitre.

Adolescent↗
PubMed1984

Prophylaxis and treatment of endemic goitre in Western Sudan with intramuscular iodized oil.

A single injection of iodized oil was administered intramuscularly in a dose of 0.2-2 ml (475 mg iodine per ml) to 383 children from the villages of Kas and Dibbis of the Darfur region in Western Sudan, where goitre is prevalent. After one year the prevalence of goitre had declined from 76% to 49.6%. Of the goitrous children, 81.1% showed either complete resolution of goitre or definite regression of its size. None of the nongoitrous children developed goitre and none of the existing goitres became larger. No cases of hyper- or hypothyroidism were observed. The full 270 children were followed up for four-and-a-half years after treatment and compared with untreated controls from the same area. The prevalence of goitre was significantly lower in the treated than in the untreated group. In treated children the mean urinary iodine excretion three-and-a-half years after treatment was 188.7 micrograms/g creatinine. This was significantly higher than in the untreated group (P less than 0.001). One year later the mean urinary excretion of iodine in the treated children had decreased to 87.1 micrograms/g creatinine. There was no difference in the mean serum values of T3 and T4 in the treated and untreated groups. The level of thyroid stimulating hormone was significantly lower in the treated [mean (S.D.) = 3.5 (0.9)] than in the untreated children [6.0 (3.5)]. It is concluded that a single injection of iodized oil is safe and effective in prevention of goitre development, reduces goitre size and maintains a sufficient iodine supply to prevent goitre for at least four-and-a-half years in children from goitre-endemic areas in Western Sudan.

Adolescent↗
PubMedDate not supplied

The use of plasma fructosamine in the assessment of diabetic control.

Plasma fructosamine and glycosylated haemoglobin were measured in insulin-dependent (n = 30) and in non-insulin-dependent diabetics (n = 90) and in healthy controls (n = 45). Fructosamine correlated significantly with glycosylated haemoglobin in the non-insulin dependent (r = 0.5, P less than 0.001) better than in the insulin-dependent group (r = 0.39, P less than 0.05). No correlation was found between plasma fructosamine and albumin or total protein concentrations when the concentrations of albumin and protein are within normal reference range. The fructosamine test has got many desirable characteristics, which will give it a role in the assessment of diabetic control.

Adult↗