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E Mortier

Publications and source records attributed to E Mortier.

84 records · Page 5Linked to original sources
PubMed1988

Comparison of evoked electromyography and mechanical activity during vecuronium-induced neuromuscular blockade.

The relationship of compound electromyography to mechanical myography was investigated in 20 patients given vecuronium in a dose of 0.1 mg kg-1. Mechanical response was affected less quickly and recovered faster than the electrical response. Although there was a good correlation between the two throughout the study, a shift towards mechanical responses was observed in all cases for the onset of blockade and recovery from blockade. Moreover, during recovery the mechanical responses became greater than the control value in all patients. This was also reflected in the statistically significant difference (P less than 0.05) of the regression lines relating tension and electromyography (TI as well as train-of-four ratio) between onset of, and recovery from, neuromuscular block.

Electromyography↗
PubMed1988

Noncompartmental pharmacokinetic analysis of nondepolarising neuromuscular blocking agents.

Noncompartmental pharmacokinetic methods using the statistical moment theory can be very helpful in comparing the mean residence time of drugs in the body. These methods are based on the estimation of the area under the time versus plasma concentration curve after a single intravenous drug bolus, and can also be used to estimate clearance, effective half life and the apparent volume of distribution of the drug. In the group of nondepolarising neuromuscular blocking drugs, atracurium offers the advantage of having the smallest mean residence time.

Half-Life↗
PubMed1987

Priming with vecuronium and atracurium--a comparison.

Vecuronium (V) and atracurium (A) were compared in a randomised study in premedicated patients undergoing laparoscopy for gynecological pathology. Both groups contained ten patients. Anesthesia was induced with fentanyl (0.1 mg) and thiopentone (1 mg/kg initially and subsequently 4 mg/kg). A priming dose of vecuronium (20 micrograms/kg) or atracurium (100 micrograms/kg) was given one minute before the intubating dose (60 micrograms/kg for vecuronium and 300 micrograms/kg for atracurium). Ninety seconds thereafter intubation was performed. Maintenance of anesthesia consisted of isoflurane at an inspiratory concentration of 1% in a mixture of O2/N2O (50%/50%) with small supplements of fentanyl. Neuromuscular block was monitored with the Datex Relaxograph. Results show that neither drug offers major clinical advantages over the other: there is no difference in speed of onset (V:T190sec 14.6 +/- 4.3%; A:T190sec 23.5 +/- 6.5%; Mean +/- SEM) and duration of neuromuscular block (V:T150sec 34.2 +/- 3.5 min; A:T150sec 41.3 +/- 2.8 min; Mean +/- SEM) and intubation conditions are almost identical.

Adjuvants, Anesthesia↗
PubMed1987

The use of combined high-frequency jet ventilation and intermittent positive pressure ventilation in bilateral bronchopleural fistulae.

Dissatisfaction with the results of conventional respiratory support has led to the use of high-frequency jet ventilation in desperate clinical situations with severe acute respiratory failure. We report a case of a 77 year old man with bilateral bronchopleural fistulae, who was ventilated with a combination of intermittent positive pressure ventilation and high-frequency jet ventilation. The hemodynamic and respiratory advances of this combination are discussed in an overview of the literature.

Aged↗
PubMed1987

A comparison of midazolam and diazepam for sedation during locoregional anesthesia.

Midazolam is a recently introduced benzodiazepine with a half life of 1-4 hours. Midazolam (0.15 mg/kg) has been compared with diazepam (0.2 mg/kg) for sedation during locoregional anesthesia in 60 premedicated patients. No difference among the two groups for heart rate, bloodpressure, respiratory rate and incidence, and duration of apnoea was noticed after an i.v. bolus administration. The recovery time was equal in both groups. Midazolam was significantly less painful at injection. The sedation pattern between both groups is only different at 60 minutes, where more better sedated patients are seen in the midazolam group. Except the pain at injection and a better sedation pattern after 60 min. the differences in the other parameters are only borderline.

Adult↗
PubMedDate not supplied

Chronic pain therapy: an evolution from solo-interventions to a holistic interdisciplinary patient approach.

The treatment of chronic pain patients has changed over years. Anaesthesiologists treat pain patients, their skills in locoregional anaesthesia techniques and their pharmacological knowledge being a unique resource to reduce pain. However, the International Association for the Study of Pain provides more and more scientific evidence that chronic pain is a biopsychosocial event and that its diagnosis and treatment should be considered in a multidisciplinary frame. Nevertheless, in practice we can't deny the fact that there are several steps in the process in which the patient himself decides if he wants such an approach or not. The 'motivating' phase is a very important pretherapy and basic condition to start up a holistic pain treatment. Therefore, at the Ghent University Hospital Pain Clinic, we focused in a first step how to motivate our pain patients to take part in a multidisciplinary diagnostic examination, the second step is motivate them for an interdisciplinary treatment when it is indicated. We diagnose the four most important pain components: the sensory, myofacial, autonomic and psychosocial problems. The patient who is initially examined by the anaesthesiologist, will also be evaluated by the psychologist and the physician in rehabilitation medicine. By this way each component is mapped and a final (holistic) diagnosis can be made. In a weekly half-a-day meeting, the different specialists discuss the patients and put forward an interdisciplinary treatment plan. On several moments, the patients' treatment progress will be discussed and redirected if necessary. So, we hope to obtain an optimal result and avoid overtreatment and too invasive pain treatment.

Adolescent↗
PubMedDate not supplied

Operative closure of patent ductus arteriosus in the neonatal intensive care unit.

Preterm infants undergoing surgical closure of patent ductus arteriosus are usually critically ill and are suffering from many concomitant diseases. The high risk of increased morbidity in transferring them from the neonatal intensive care unit (NICU) to a distant operating room is generally recognized. For this reason we report our experience in 33 premature infants with patent ductus arteriosus who have been operated in the NICU over a six-year period. There were no operative or immediate postoperative deaths and the 30 days hospital mortality was 6%. Based upon these findings we can confirm that operative closure of PDA can be performed safely in the NICU.

Comorbidity↗