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Biomedical subjects

E Mora

Publications and source records attributed to E Mora.

At least 37 records · Page 2Linked to original sources
PubMed1990

Isolation and characterization of a lectin from the seeds of Dioclea lehmanni.

Affinity chromatography of the globulin fraction from the seeds of Dioclea lehmanni on Sephacryl S-200 yielded two lectins, one slightly retarded and another strongly bound. The latter, which was a glucose/mannose specific lectin, was purified and the following properties were determined: pI, Mr of subunits, carbohydrate content, A, aminoacid composition, hemagglutination and inhibition patterns, N-terminal sequence and mitogenic activity. These properties of the lectin were very similar to those of the Con A and Dioclea grandiflora lectins.

Amino Acids↗
PubMed1989

Chief complaint of 3,545 pediatric patients at the emergency room of San Pablo Hospital during a five months period.

A survey was made of the chief complaints at the Emergency Room of San Pablo Hospital of 3,545 pediatric patients seen between January 1 and May 31, 1988. Most common chief complaints involved the gastrointestinal system, trauma, and fractures. There was a wide range of chief complaints. Periodic surveys of this type should be useful in establishing priorities of pediatric training.

Adolescent↗
PubMed1986

The distribution of arsenic and cobalt in patients with laryngeal carcinoma.

The objective of this study was to evaluate tissue and plasma concentrations of arsenic and cobalt in an attempt to discover the role of these elements in the malignant process. Using neutron activation analysis, arsenic and cobalt levels were determined in plasma and in non-malignant and malignant human tissues in 15 patients with laryngeal carcinoma. Arsenic and cobalt levels were about 60% higher in tumor than in adjacent non-malignant tissue (P less than 0.001): arsenic 72.4 +/- 18.0 ng/g versus 43.1 +/- 9.4 in non-malignant tissues, and cobalt 68.7 +/- 7.3 ng/g versus 39.6 +/- 7.0 in non-malignant tissues. Mean plasma arsenic and cobalt levels were also significantly higher in patients with laryngeal carcinoma than in healthy control subjects.

Adult↗
PubMed1986

Plasma and tissue levels of some lanthanide elements in malignant and non-malignant human tissues.

Lanthanum (La) levels in plasma, in erythrocyte hemolysate and in tissue from healthy subjects and patients with laryngeal carcinoma were determined by neutron activation analysis. Plasma lanthanum levels were significantly higher in laryngeal carcinomas than in either healthy controls or in subjects suffering from localized inflammation (e.g. epicondylitis of the elbow) (p less than 0.001). The mean La concentration in malignant tissue samples was 57.5 +/- 7.2 ng g-1; the corresponding level in normal adjacent tissue from the same organ was 94.6 +/- 12.0 ng g-1. This 61% decrease in the concentration of La in malignant tissues was highly significant (p less than 0.001). In patients with laryngeal carcinoma we did not observe any detectable level of lanthanum in erythrocyte hemolysate; the mean La erythrocyte hemolysate level in healthy controls and in patients suffering from localized inflammatory condition was 14.3 and 33.2 ng ml-1, respectively. Further studies are in progress to evaluate whether or not this element can serve as a marker for diagnosis or prognosis in cancer.

Adult↗
PubMed1985

Choroid plexus papilloma containing bone.

The presence of bone in choroid plexus papillomas is a rare event. The authors report a case of choroid plexus papilloma of the IVth ventricle containing bone in a 18-year-old man, and review two previously reported cases, as well as the mechanisms proposed for the presence of bone and cartilage in neuroepithelial neoplasms.

Adolescent↗
PubMed1985

Effects of caponization on body weight, atherosclerosis, and cardiovascular variables in hypertensive and hypotensive turkey lines.

Effects of caponization and blood pressure selection on serum lipids, severity of atherosclerosis, body weight, hematocrit, and relative ventricular weight in hypertensive and hypotensive lines of turkeys were evaluated in two trials. At 8 weeks of age, half the turkeys from each line were caponized. Body weights, blood pressure, and blood samples were obtained from each treatment at 8, 20, and 30 weeks of age. A total of 56 and 72 birds were used in Trials 1 and 2, respectively. Birds were necropsied at 30 weeks of age. Hypertensive turkeys had significantly greater serum cholesterol and total lipid than hypotensive turkeys only at 30 weeks of age in Trial 1. Lower relative ventricular weights were observed in hypotensive turkeys within both trials. Hypertensive birds exhibited a more severe degree of atherosclerosis and higher relative heart weight than hypotensive turkeys. Caponization significantly increased total serum lipid only at 20 weeks of age in Trial 2. Average body weight of caponized turkeys was significantly lower (1.2) than the control turkeys at 30 weeks of age. Caponized turkeys exhibited lower relative ventricular weight in Trial 1 but not Trial 2 and an increase in blood pressure only in Trial 2. Caponization suppressed body weight, decreased hematocrit values, and had no significant effect upon plaque severity. The presence or absence of male sex hormones had virtually no effect on proposed atherogenic stimuli thereby suggesting another mechanism by which the female is afforded a higher degree of protection.

Animals↗
PubMed1980

[Lidocain clearance after oral and intravenous application in rats with low grade ANIT-cholestasis and galactosamine-induced hepatitis (author's transl)].

Each of 6 rats with a low grade of ANIT-cholestasis and a low grade of GalN-hepatitis received either 3 mg Lidocain i.v. or 24 mg Lidocain orally. The plasma concentrations of Lidocain were measured over a period of 3 1/2 hrs. The systemic clearance of Lidocain (Cli.v. = Di.v. divided by AUCi.v.) was significantly increased on ANIT-cholestasis (17 +/- 3) and GalN-hepatitis rats (13 +/- 2) (control rats: 7 +/- 1 ml/min x 100 g bw). Oral clearance of Lidocain (Clor = Dor divided by AUCor) was not significantly different in the three respective groups. In both groups with experimental liver disease the hepatic blood flow--calculated by comparing the systemic to the oral clearance--was significantly increased (22 +/- 4 and 19 +/- 3 vs 8 +/- 1 ml/min x 100 g bw). Due to this increase, the hepatic extraction ratio of Lidocain was significantly decreased (ANIT-cholestasis 0.73 +/- 0.07; GalN-hepatitis 0.74 +/- 0.05; controls 0.85 +/- 0.03). Because of an increase of systemic Lidocain clearance, no toxic plasma concentrations were observed.

1-Naphthylisothiocyanate↗
PubMedDate not supplied

[Characterization of neuronal ceroid lipofuscinosis in Venezuelan children].

INTRODUCTION: Neuronal ceroid lipofuscinosis (NCL), represents a group of inherited neurodegenerative disorders. Based on the age of the patient at onset, clinical course and ultrastructural morphology it has been identified three clinical types for the pediatric group: 1) Infantile NCL (INCL); 2) Late infantile NCL (LINCL); and 3) Juvenile NCL (JNCL). Other variants or atypical forms represent around 20% of the NCL in different populations. Genetic advances have made possible a better characterization, diagnostic and classification of these disorders. CASE REPORTS: We present the clinical, neurophysiological, neuroradiological, and morphological data from 6 patients with NCL, who were assessed at the pediatric neurology department of the Hospital Universitario de Maracaibo during a ten years period (1993 2003). All 6 cases corresponded with the late infantile form. Age of onset ranged form 2 to 5 years. For most of the patients initial symptoms included seizures, psychomotor delay, accompanied by macular degeneration and optic atrophy. The EEG was characterized by high voltage spikes elicited by low frequency photic stimulation, in 5 cases. Neuroimaging findings were characteristic of the late infantile form of the NCL. In three patients a decreased intensity of signal was seen in the thalami and putamen on T2-weighted images. The ultrastructural examination of the samples obtained through a biopsy showed curvilinear bodies in all patients. CONCLUSION: There is not epidemiological data of the NCL in Venezuela; it is presumed the presence of clinical forms and variants in the pediatric group. This first study could contribute to the knowledge and a better research of this group of disorders in our population.

Child, Preschool↗
PubMedDate not supplied

Plasma and synovial fluid lanthanides in rheumatoid arthritis: variations after intra-articular therapy.

Lanthanides (Ln), or rare earth elements, are detectable in trace amounts in organisms. Increased concentrations of Ln have been observed in rheumatoid arthritis (RA) in plasma (pl) and synovial fluid (Sf). We have evaluated pl and Sf concentrations of Ln (in particular La, Nd, Ce, Yb, Lu, Eu), in rheumatoid arthritis patients, before and after intra-articular steroid injection. Increased pl and Sf concentrations of Ln were confirmed in RA. No detectable synovial fluid concentrations of Ln were observed in healthy controls. A statistically significant Ln reduction (p less than 0.001) was observed in Sf 3 and 6 days after local steroid injection and in pl after 6 days. The decrease in Ln concentrations in Sf and pl, after antiphlogistic therapy, reflects the reduction of the inflammatory condition.

Adult↗