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Biomedical subjects

E Montserrat

Publications and source records attributed to E Montserrat.

At least 325 records · Page 18Linked to original sources
PubMed1984

Bone marrow histologic pattern--the best single prognostic parameter in chronic lymphocytic leukemia: a multivariate survival analysis of 329 cases.

In previous studies, the prognostic value of bone marrow (BM) histologic patterns in chronic lymphocytic leukemia (CLL) has been demonstrated. In order to investigate whether such a value is independent of other prognostic parameters, a multivariate survival analysis (Cox's regression model) was undertaken in a series of 329 CLL patients in whom a BM had been performed. The following binary variables were included in the analysis: age (more than 60 years), lymphadenopathy (more than two areas involved), splenomegaly, hepatomegaly, absolute lymphocyte count (more than 30,000 microL), anemia (hemoglobin less than 10 g/dL), thrombocytopenia (less than 100,000 microL), and BM pattern (diffuse v nondiffuse). Three variables entered the regression at significant level: BM pattern (P less than .001), anemia (P less than .001), and hepatomegaly (P = .03). The model was also tested by expressing the variables in a continuous way when possible. Again, BM pattern entered first in the regression (P less than .001), followed by the hepatomegaly (P = .002), hemoglobin level (P = .02), and lymphadenopathy (P = .04). When both the binary and the continuous models were tested separately in 227 patients with BM as initial staging procedure and in 102 patients in whom this was performed later during the course of the disease, in all instances, BM pattern entered first in the regression at a highly significant level. BM histologic pattern appears to be a better single prognostic parameter than any one of the variables employed in current clinical staging systems. A combined clinicopathologic system incorporating the BM pattern, together with the usual clinical variables, is presented.

Actuarial Analysis↗
PubMed1983

Cross-resistance to alkylating agents in multiple myeloma.

In order to ascertain whether multiple myeloma patients resistant to one alkylating agent would respond to a second one, high-dose intermittent cyclophosphamide was administered to 12 patients showing resistance to melphalan and prednisone. On the other hand, intermittent melphalan and prednisone treatment was employed in eight myeloma patients resistant to intermittent cyclophosphamide. Only one objective response was achieved among 12 patients on cyclophosphamide therapy, in spite of having employed high doses of this alkylating agent. No responses were achieved with melphalan in the group of cyclophosphamide-resistant patients. The median survival probability was 8.7 months (SD +/- 2.9) for all patients after starting the second alkylating agent. These results suggest cross-resistance between melphalan and cyclophosphamide in myeloma. The authors conclude that a single second alkylating agent cannot be recommended as a treatment of patients with multiple myeloma who are truly refractory to one alkylating agent.

Alkylating Agents↗
PubMed1983

Electrophoretic and kinetic studies of a new mutant red cell pyrimidine 5'-nucleotidase.

Molecular characteristics of a deficient pyrimidine 5'-nucleotidase (P5N) were studied in a partially purified red cell enzyme extract. The results showed a high Michaelis constant for uridine 5'-monophosphate, an acidic shift of the optimum pH and normal heat stability. Enzyme electrophoresis using a starch gel and histidine-citrate buffer pH 7.0 showed a single band with identical mobility to that of the 'minor' band of normal enzyme. This electrophoretic pattern supports the hypothesis that P5N deficiency is, at least in some cases, a consequence of the absence of a 'major' isoenzymatic band characteristically present in normal enzyme.

5'-Nucleotidase↗
PubMed1983

Bone marrow biopsy in chronic lymphocytic leukaemia: a study of 208 cases.

In 208 cases of chronic lymphocytic leukaemia (CLL) in which a bone marrow biopsy has been performed, the correlation between histopathological bone marrow patterns (interstitial, nodular, mixed and diffuse) and both Rai's clinical stages and the recent International Workshop on CLL proposal (A, B, C stages) has been analyzed. In general, a fairly good correlation has been found between the bone marrow patterns and both Rai's and A, B, C systems. As far as the correlation between the bone marrow patterns and the tumoral load (lymphadenopathy, organomegalies, lymphocytosis, anaemia and thrombocytopenia) is concerned, the correlation was also fairly good. Bone marrow pattern is an important prognostic factor in CLL and it is suggested to use a combined clinical and pathological (bone marrow biopsy) staging in CLL.

Aged↗