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Biomedical subjects

E Monos

Publications and source records attributed to E Monos.

At least 91 records · Page 5Linked to original sources
PubMed1979

Effect of acute ischaemia on active and passive large deformation mechanics of canine carotid arteries.

Large deformation mechanical properties of dog carotid arteries excised following 1 hour of ischaemia and 1 hour of reperfusion were compared to those of contralaterial normal arteries in vitro. Vascular smooth muscle was invariably activated by 0.5 microgram/ml noradrenaline. Relative reduction in the diameter of postischaemia arteries following noradrenaline administration was twice as large (max.: 13.2 +/- 2.0%) as that of normal controls (max.: 5.7 +/- 1.5%) in the pressure range of 0--220 mmHg. If the smooth muscle was totally relaxed there were no differences between the geometrical (wall-thickness, radius) and mechanical properties (stress, incremental elastic modulus, incremental distensibility, strain-energy density) of the arteries in the two series. It is concluded that the increased reactivity of postischaemic arteries is not caused by changes in geometric or mechanical properties of their passive wall elements.

Animals↗
PubMed1978

Direct effect of physiological doses of arginine vasopressin on the arterial wall in vivo.

Effects of topically applied arginine vasopressin (VPA), in 100-150 muU/ml blood concentration, on external diameter (D) and on dynamic elastic modulus (E*) of surgically denervated common carotid (CC) and femoral (FA) arteries have been studied before and after hypophysectomy in anesthetized dogs. Changes in D, E*, and flow resistance (R) of the CC and FA vascular beds before and after removal of the pituitary were also determined. It was found that VPA elicited a substantial (max 21-26%) decrease in E* and a smaller (max 5.9-6.9%) reduction in D of FA independent of the presence of absence of the pituitary gland. The VPA effect developed more rapidly after hypophysectomy than before. In the CC, VPA did not significantly affect values of E*. During the 1-h period after hypophysectomy, statistically significant decreases in E*-CC, E*-FA, and D-CC were observed, but D-FA did not change, although arterial pressure as well as R-FA and R-CC were diminished. These results give further support to physiological vascular actions of VPA and a possible role in short-term circulatory control. In large arteries, the effects of VPA also seem to be regionally differentiated.

Animals↗
PubMed1977

Is the sclerotic vessel wall really more rigid than the normal one?

Quasistatic passive mechanical properties of fibrosclerotic and normal human anterior cerebral arteries were studied in vitro. Mechanical properties were characterized by incremental elastic modulus, strain energy density and incremental distensibility for a 20--250 mm Hg intraluminal pressure range. Fibrotic arteries were found to have a 34--45% lower elastic modulus at the same pressure levels than normal ones (p less than 0.01--0.02). Distensibility however proved to be only 28--35% higher in the fibrotic group, this difference was significant just at a few pressure values above 120 mm Hg. This was due to the opposite changes in elastic properties and radius to wall thickness ratio. It is supposed that higher elasticity of the fibrotic arterial wall is the consequence of a local compensatory process tending to prevent pathological alterations in distensibility of the arteries.

Arteries↗