Thymidine and thymidylate kinase, and thymidylate phosphatase in human leukemic leukocytes.
Explore the source record for details and available documents.
Humans↗
Biomedical subjects
E Michael
Publications and source records attributed to E Michael.
Episodic adenolymphangitis and lymphoedema in patients with bancroftian filariasis.
In order to explore the relationship between acute and chronic disease, age-specific data on the frequency and duration of episodic adenolymphangitis (ADL) in patients with 3 defined grades of lymphoedema in bancroftian filariasis were examined. The age distribution of grades I and II exhibited a convex age profile, but that of grade III showed a monotonic increase. The mean duration of oedema increased with its grade (grade I, 0.3 years; grade III, 9.9 years). The mean number of ADL episodes in the previous year for all cases was 4.2 and it increased with grade (grade I, 2.4 and grade III, 6.2). The mean duration of each ADL episode for all cases was 4.1 d and it was independent of grade and age. The mean period lost to ADL episodes in the previous year was 17.5 d; it increased from 9.4 d with grade I to 28.5 d with grade III. The results imply that there is a dynamic progression through the grades of lymphoedema and that the frequency of ADL episodes is positively associated with this progression. However, the study design could not separate cause from effect.
Adult↗
Wuchereria bancrofti microfilaraemia in children in relation to parental infection status.
A total of 946 families with 2302 children was surveyed for microfilaraemia due to Wuchereria bancrofti. The prevalence of microfilaraemia among offspring born to microfilaraemic parents was significantly higher than in those born to amicrofilaraemic parents (P = 0.0049; relative risk = 3.40). However, there was no statistically significant difference between the prevalence of microfilaraemia in children born to microfilaraemic mothers or microfilaraemic fathers, suggesting that parental (not only maternal) infection is the important risk factor, and it may be exposure within the household which is important. Logistic regression analyses also confirmed that the risk of infection for offspring born to either microfilaraemic mothers or microfilaraemic fathers was higher than that for offspring born to amicrofilaraemic parents and indicated that infection in children < or = 20 years old was primarily dependent on parental infection status and minimally influenced by factors other than household exposure.
Adolescent↗
Protocol for lower extremity trauma.
Trauma to the lower extremity has been treated in the past by many specialties and subspecialties of medicine. No specialty, however, should be better qualified or trained in treating lower extremity trauma than the podiatrist. This study reviews some critical principles of acute trauma management and treatment. A simple algorithm is suggested. Three representative case studies are presented, demonstrating the importance and value of an established protocol.
Adult↗