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Biomedical subjects

E Mezey

Publications and source records attributed to E Mezey.

At least 217 records · Page 12Linked to original sources
PubMed1980

Myelinated dendrites of Purkinje cells in deafferented cerebellar cortex.

Following chronical (30--60 days) isolation of cerebellar vermis in developing and in adult rats, partially myelinated primary and secondary dendrites of Purkinje cells and myelinated Golgi, basket and stellate cell bodies were observed. The dendritic myelin sheaths were not continuous with but developed independently of preexisting axonal myelin. Experiments on rats and cats have additionally revealed that this redundant myelinization of Purkinje dendrites and of interneuronal perikarya can be elicited also by selective destruction of the olivocerebellar (climbing fibre) afferents, indicating a direct influence of climbing fibre afferentation on myelinization processes in the cerebellar cortex.

Afferent Pathways↗
PubMed1979

Effect of ethanol feeding on bone composition in the rat.

The effect of ethanol feeding for a period of 3 months on the mineral and collagen content of bone was determined in the rat. Ethanol feeding resulted in no changes in the density or in the concentrations of calcium, phosphorus, hydroxyproline, or nitrogen in the tibiae. Also, the serum concentrations of calcium, phosphorus, and 25-hydroxyvitamin D were unaffected by ethanol feeding. The development of a mild degree of osteomolacia was suggested, however, by decreases in EDTA-extractable mineral content and in the calcium/hydroxyproline ratio in the tibiae of the ethanol-fed as compared with the control animals. The urinary excretion of glycosaminoglycans was not changed by ethanol-feeding while the urinary excretion of peptide-bound hydroxyproline was increased. The minimal bone changes found after ethanol feeding in this study are an unlikely cause for the observed increases in the urinary excretion of hydroxyproline.

Alcoholism↗
PubMed1979

Pituitary-brain transport of neurotensin: functional significance of retrograde transport.

The ability of the peptide neurotensin (NT) to affect central nervous system function after pituitary-brain transport was examined in adult male rats. Animals were anesthetized and maintained under ether and their pituitaries were exposed by the pharyngeal route. They were then given NT or physiological saline solution by various routes of administration, and colonic temperature (CT) was monitored over a 2-h period. Animals given intracerebroventricular injections of 10 micro g NT showed significantly lower colonic temperatures over the 2-h-measurement period compared to rats injected intraventricularly with the solvent vehicle (0.15 M NaCl). Intrapituitary injection of 10 or 50 micro g NT also markedly decreased CT in a dose-related manner compared to rats given similar injections of the solvent vehicle. Section of the pituitary stalk 24 h before injection of 50 micro g NT into the pituitary totally abolished the hypothermic effect of the peptide. NT in a dose of 50 micro g did not significantly modify CT when injected either iv or into the space between the pituitary and the dura compared to animals given the solvent vehicle. The results suggest that peptides may undergo retrograde transport from the pituitary to appropriate sites in the central nervous system and retain their ability to affect brain function.

Animals↗
PubMed1979

Sampling variability on percutaneous liver biopsy.

Sampling variability of liver biopsy was determined in three consecutive biopsy specimens obtained from each of 118 patients immediately prior to autopsy. No sampling variability was found for fatty liver, alcoholic hepatitis, nonspecific hepatitis, fulminant hepatitis, leukemic infiltrate, and venous congestion. Cirrhosis was diagnosed in 80% of cases at the first biopsy but in all cases after three biopsies. Chronic aggressive and chronic persistent hepatitis were diagnosed correctly in two of three cases each at the first biopsy, and in all cases after three biopsies. Metastatic carcinoma was detected in 46% of cases at the first biopsy and in 69% after three biopsies. Granulomas were missed once on the first biopsy, but found on a subsequent biopsy. The amounts of fat and fibrosis in the biopsy specimens often were not representative of the amounts present at autopsy.

Biopsy, Needle↗
PubMed1978

Induction of alcohol withdrawal symptoms by nalorphine in chronic alcoholic patients.

The effect of nalorphine on eliciting symptoms of either alcohol or narcotic withdrawal was studied. Five male alcoholics were challenged with nalorphine and saline, both while sober and during alcohol ingestion. After nalorphine, pulse rate decreased in patients when sober, but increased when they were ingesting alcohol. Nalorphine administration resulted, during alcohol ingestion, but not in the sober state, in lacrimation, a symptom of narcotic withdrawal, in one patient, and in the following symptoms of alcohol or narcotic withdrawal in one or more patients: weakness, anorexia, insomnia, disorientation, and tremor. These findings suggest that morphine-like alkaloids play a role in the mediation of alcohol withdrawal symptoms.

Adult↗
PubMed1978

Liver disease and nutrition.

The liver plays a central role in the digestion, metabolism, and storage of nutrients. A deficiency of nutrients is often associated with liver disease and may be caused by decreased intake, decreased absorption, decreased storage, abnormalities in metabolism, or the increased requirements for nutrients. Alcoholism is a frequent cause of both malnutrition and liver disease, but nutritional deficiencies are also common in liver diseases not associated with alcoholism.

Alcoholism↗
PubMed1978

Corticosteroid therapy of alcoholic hepatitis.

Fifty-five patients with alcoholic hepatitis were studied in a 28- to 32-day randomized double blind treatment trial comparing prednisolone (40 mg per day) with placebo therapy. Of 31 placebo-treated patients, 4 died during the study interval and 2 more died within 5 days of study completion. Only 1 of 24 prednisolone-treated patients died during the same interval (Fisher exact test; P = 0.10). Stepwise discriminant analysis of laboratory factors associated with death revealed independently significant associations with prolongation of prothrombin time and height of serum bilirubin at the initiation of the study. When treatment was included as a variable in this discriminant analysis, it was found that corticosteroid therapy significantly decreased mortality (P less than 0.05). The corrected wedged hepatic venous presure decreased to a similar extent in the two groups. These studies suggest that corticosteroid therapy does decrease early mortality in patients with severe alcoholic hepatitis, but has no short term effect on the development of portal hypertension.

Adult↗
PubMed1977

Serial and triadic synapses in the cerebellar nuclei of the cat.

A quantitative electron microscopic investigation of the nucleus interpositus in cat cerebellum reveals that about 1.5% of all observed synapses are established between synaptic vescile-bearing profiles. It is shown by serial sections that 70% of these synaptic complexes are triadic arrangements and 30% are serial synapses. Further analysis discloses that the first presynaptic element in the triadic and serial synapses may be one of four different axonal types: (A) Purkinje-cell axons; (B) and (C) afferent fibers containing large round vesicles and originating from the brain stem (probably mossy and climbing fiber collaterals); and (D) axon terminals containing small round vesicles. Indirect evidence suggests that type D profiles are the recurrent axon collaterals of the projective neurons. The second, postsynaptic and presynaptic, vesicle-bearing process in these complexes is either a class D terminal, or a somewhat more "dendrite-like" profile (Class E) containing flattened vesicles, and identified as belonging to processes of local Golgi type II interneurons.

Animals↗