[A study of method for enhancement of perfusion flow in experimental cerebral ischemia--Part 2. Hypercapnia with mannitol (author's transl)].
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Biomedical subjects
Publications and source records attributed to E Meyer.
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10 prostheses with individually cut attachments and 50 prosthetic appliances with parallel walled telescopic crowns were tested for their retention after a wear of between 2 and 7 1/2 years. Of the attachments only 3 cases showed good retention; in 4 it was minimal and no rentention was seen in 3 cases. Good retention was maintained in 10 telescoping prostheses, 24 had minimal and 16 no retention. Severe grades of loosening was only seen in telescoping supporting teeth where the anchor had good friction.
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Cotton wool exudates were found in a patient during a flare-up of seropositive rheumatoid disease with polyarthritis and pericarditis. After therapy with cortisone a concomitant improvement of the cardiac arthritic and fundal lesions was observed. It is suggested that the fundal lesions in this patient were due to the rheumatoid disease.
A report of a patient with spontaneous luxation of the globe and a branch thrombosis of the central retinal vein is presented. The causal relationship of the two phenomena is discussed.
Glutamine phosphoribosylpyrophosphate amidotransferase, purifed to better than 98% purity from derepressed Bacillus subtilis, exists as a tetramer and as a dimer of apparently identical subunits with a molecular weight of 50,000 each. The enzyme contains 3 atoms of iron and 2 atoms of inorganic sulfide per subunit and has a yellow-brown color. The absorption spectrum is not altered by dithionite, but exposure to oxygen causes inactivation and partial bleaching of the visible spectrum. Thus, the Bacillus amidotransferase exhibits novel structural features and a new reaction type of proteins of the iron-sulfur group.
Clinical and pathologic changes in 87 patients who could not be resuscitated from an episode of sudden cardiovascular collapse are described and compared with observations from patients in the same community who were successfully resuscitated from ventricular fibrillation. Findings in patients who died suddenly generally did not differ when the patients were groups by electrocardiographic rhythm on arrival of the mobile coronary aid unit. The pathologic changes of acute thrombosis and recent myocardial infarction did not occur with sufficient frequency in the entire group to be considered causally related to the sudden collapse, occurring in 10 and 5 percent of cases, respectively. Although most patients had evidence of obstructive coronary disease and old myocardial infarction, 8 percent had no significant vascular disease, acute thrombosis, myocarditis or valve disease that might be implicated as a factor in sudden death. There was no relation between age and severity of obstructive coronary disease or frequency of old myocardial infarction in patients who died suddenly. Complete atherosclerotic occlusion in one or more coronary vessels occurred in 51 of 87 (59 percent) and old myocardial infarction in 48 of 87 (55 percent). Although the mean age of this autopsy population was similar to that of all patients in the community who have had ventricular fibrillation on arrival of the aid unit, the nonsurvivors had a greater incidence of myocardial infarction and symptomatic heart disease (73 of 87) than did survivors. Comparison of this autopsy group with persons from the community who were resuscitated from ventricular fibrillation and subsequently had coronary angiograms indicates that the severity of coronary stenosis does not distinguish between survivors and nonsurvivors of an episode of ventricular fibrillation and suggests that other factors influence the outcome of an episode of ventricular fibrillation.
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Methysergide, a serotonergic receptor blocker, was studied to determine its effects against d-amphetamine-induced excitation as measured by convulsions elicited by handling in mice. Significant intensification (p less than 0.01) of the action of d-amphetamine was observed in mice. These results indicate that reduction in serotonergic activity in the central nervous system enhances excitation induced by d-amphetamine.
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Dynamic positron emission tomographic studies were performed on over 120 patients with occlusive cerebrovascular disease, arteriovenous malformations, and brain tumors, using the positron section scanner, consisting of a ring of 32 scintillation detectors. The radiopharmaceuticals were nondiffusible 68Ga-EDTA for transit time and uptake studies and the diffusible tracer, 77Kr, for quantitative regional cerebral blood flow studies in every square centimeter of the cross section of the head. The results of dynamic positron emission tomography in correlation with the results from the gamma scintillation camera dynamic studies and computed tomography (CT) scans are discussed.
A case of chronic simple glaucoma associated with 'moth-eaten-like' iris atrophy is presented. In spite of bilateral glaucoma the iris atrophy is only in one eye and is associated with uncontrolled intraocular pressure.
The catalasic activity of a non-proliferating suspension of Pseudomonas fluorescens incubated in a buffer shows after six hours, an increase of 100% in presence of phosphates and 30% in presence of Tris. This increase, which consists in a neosynthesis of the enzyme, is in relation with the lysis of a part of the bacterial suspension.