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Biomedical subjects

E Mesdjian

Publications and source records attributed to E Mesdjian.

At least 37 records · Page 2Linked to original sources
PubMed1980

Carbamazepine intoxication due to triacetyloleandomycin administration in epileptic patients.

In 17 epileptics receiving carbamazepine (CBZ) alone or in combination with other anticonvulsant drugs, administration of triacetyloleandomycin (Tri A) led to an acute and unexpected intoxication (drowsiness, nausea, vomiting, and dizziness). Similar symptoms occurred again in 3 patients after Tri A was administered a second time. The same toxic manifestations were observed in two patients receiving CBZ and erythromycin. A rapid increase in plasma levels of CBZ occurred after institution of Tri A therapy in 6 patients, the CBZ levels quickly returning to normal after withdrawal of Tri A. Thus, it is suggested that the observed intoxication is due to the simultaneous administration of CBZ and Tri A (or erythromycin). The possible role of hepatic dysfunction in this syndrome of intoxication is discussed. Furthermore, the intoxication may be at least partially related to serum electrolyte disturbances, as suggested by one case in which obvious signs of water intoxication were detected. The severity and frequency of intoxication should lead to proscribing Tri A or other macrolide antibiotics in patients receiving CBZ.

Adolescent↗
PubMed1980

[Paroxysmal dyskinesia during treatment with diphenylhydantoin].

Paroxystic-dyskinesias occurred in ten patients with encephalopathy and severe epilepsy associated with intellectual deficiences, during treatment of the epilepsy with diphenylhydantoin (DPH). The abnormal movements were usually paroxystic in nature and were mainly athetosic or choreic in nature affecting more particularly the facial region. None of the patients showed neurological signs during the attacks, which could have suggested an overdose of DPH, and the EEG showed no alterations. Blood levels of DPH were measured during the attacks in 9 of the patients and were within therapeutic limits in 6 cases. They were at toxic levels in the other 3 cases. All patients were receiving multiple therapy. The authors compare their findings with those in the published literature describing 46 such cases. Dyskinesias were usually observed in patients with encephalopaty. Of the 40 observations reported, blood levels of DPH were measured in 37 patients, and were found to be within normal therapeutic levels in 13 cases and at toxic levels in the other 24 patients. Clinical signs of an overdose were present in 26 cases. In all the cases reported by the authors, and in 28 cases described in published reports, the dyskinesias appeared when therapy was changed. Abnormal movements disappeared in 3 patients after an intravenous injection of diazepam. Experimental and biological arguments exist in favour of an action of DPH on the metabolism of cerebral mediators. The authors emphasize the need to investigate these dyskinetic manifestations which can be thought to be epileptic manifestations or signs of progressive encephalopathy.

Adult↗
PubMed1975

[Variations in the activity of various curarizing substances as a function of the time of administration].

This experiment was carried out upon the male-adulte-AF SPF-Wister Rat, anesthetized by the use of pentobarbital-Na at the only dosage of 40 mg/kg/IP and put under artificial ventilation. The animals were divided into two groups: Group I, "diurnal animals" curarized between 10 a.m and 4 p.m; Group 2, "nocturnal animals" curarized between 9 and 12 p.m. Four drugs of the curarimimetic (pachycurare, non-depolarizing) type: gallamine, D-tubocurarine, pancuronium and AH-8165 were studied at doses presenting the same activity. The total curarizing effect measured by the surface defined by the curve of curarization within ten mns was constantly and significantly lowered in "nocturnal animals": a 25 p. 100 diminution with gallamine, 20 p. 100 diminution with D-tubocurarine, 27 p. 100 diminution with pancuronium, 19 p. 100 diminution with AH-8165. The hypothesis is that this diminution in the action of curarizing substances may be, to a great extent, in keeping with the rise of their metabolism -- the hepatic enzymatic activity being, in the rat, a nocturnal animal, definitely increased during the night.

Animals↗