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Biomedical subjects

E McLean

Publications and source records attributed to E McLean.

10 recordsLinked to original sources
PubMed1987

The time-course of appearance and net accumulation of horseradish peroxidase (HRP) presented orally to rainbow trout Salmo gairdneri (Richardson).

1. A sensitive enzyme-linked immunosorbent assay (ELISA) technique was used in order to determine horseradish peroxidase (HRP) uptake from the rainbow trout gut. 2. HRP was detected in blood plasma and various tissues within 15 min of oral intubation. 3. The time-course of net accumulation (uptake-degradation) over a 75 min period was recorded. 4. The presence of HRP reached a maximum in the body tissues approximately 45 min after intubation and on a ng/g weight basis the order of accumulation within the tissues was liver greater than spleen = kidney greater than plasma greater than heart. 5. The total organ accumulation (net) was in the order liver greater than plasma greater than kidney greater than spleen greater than heart.

Animals↗
PubMed1986

The time-course of appearance and net accumulation of horseradish peroxidase (HRP) presented orally to juvenile carp Cyprinus carpio (L.).

A sensitive enzyme-linked immunosorbent assay (ELISA) technique was used in order to determine horseradish peroxidase (HRP) uptake from the carp gut. HRP was detected in blood plasma and various tissues within 15 min of oral intubation. The time-course of net accumulation (uptake-degradation) over a 2 hr period was recorded. The presence of HRP reached a maximum in the body tissues approximately 1 hr after intubation and on a microgram/g wet weight basis the order of accumulation within the tissues was spleen greater than kidney greater than liver. The total organ accumulation (net) was in the order liver greater than kidney greater than spleen.

Administration, Oral↗
PubMedDate not supplied

Ward teaching won't do!

Some multiply handicapped children who live in long stay hospitals do not attend school. This survey of alternative arrangements for their education made in Scottish hospitals shows that it is the children with the most severe handicaps who are taught in wards rather than in schools. Yet generally they receive little teaching time, few of their teachers have specialized training, there is limited help from other professionals, and they are taught in rooms less suitable than the most inadequate classroom. No evidence was found of any educational advantages for children being taught in a ward rather than in school.

Adolescent↗
PubMedDate not supplied

Plasma lipids and microangiopathy in insulin-dependent diabetes mellitus.

The relationship of plasma levels of high density lipoprotein (HDL) cholesterol, apolipoproteins A-I and A-II (the major apolipoproteins in HDL), low density lipoprotein (LDL) cholesterol, triglyceride, and glucose to microangiopathy was evaluated in 49 insulin-dependent diabetic subjects. Although the HDL cholesterol/LDL cholesterol ratio (a risk determinant for macroangiopathy) was lower in women with proteinuria, no other relationships between HDL cholesterol or the A apolipoproteins and renal microangiography were found. The only independent association between HDL and retinal microangiopathy was found in women, where an inverse correlation was found between the apo A-I/apo A-II ratio and the number of microaneurysms (rs = -0.561, P less than 0.05). Men showed strong relationships of glucose, triglyceride, cholesterol, and LDL cholesterol to renal microangiopathy whereas women, in general, had stronger correlations of these variables with retinal microangiopathy. Thus, several alterations in lipoprotein cholesterol distribution and HDL composition are associated with diabetic microangiopathy. In addition, differences between sexes suggest that previously undescribed hormonal factors may influence the severity of this process.

Adolescent↗