Biomedical subjects
E McIntyre
Publications and source records attributed to E McIntyre.
Dental hygiene: the consequences of a feminized profession.
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Letter to families: effective public relations strategy.
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Tandem Van de Graaff accelerator production of positron labeled radiopharmaceuticals for routine clinical use.
This paper describes a facility to produce positron labeled radiopharmaceuticals with a tandem Van de Graaff accelerator. 11C labeled carbon monoxide (11CO), 15O labeled H2O (H2 15O) and 18F labeled 2-deoxy-2-fluoro-D-glucose ([18F]2FDG), were chosen so that physiological measurements of cerebral blood volume, cerebral blood flow, and the cerebral metabolic rate for glucose could be made routinely in our PET center. This facility uses a tandem Van de Graaff accelerator which is relatively remote from the clinical area. Measurements of radionuclide yield and beam penetration showed that it was feasible to deliver sufficient amounts of radioactivity for the measurements. Both 11CO and H2 15O presented significant delivery problems due to their shorter half-lives. For H2 15O a continuous delivery system for water vapour and an infusion system for the administration of H2 15O in saline were designed and constructed. 11CO and [18F]2FDG were hand carried. This facility has demonstrated that a tandem Van de Graaff accelerator can routinely supply a PET center with adequate quantities of these three radiopharmaceuticals.
Inhaled verapamil in histamine-induced bronchoconstriction.
Fifteen asthmatic subjects participated in a double-blind trial comparing the protective effects of inhaled verapamil, salbutamol, and saline against inhaled histamine. Inhaling verapamil between four repeated histamine inhalation tests produced no significant protection against histamine-induced bronchoconstriction, while there was significant protection with salbutamol (p less than 0.001). Inhaling verapamil before a single inhalation test produced limited but significant protection (p less than 0.05) compared with a saline control in eight asthmatic subjects. This small protective effect in the two-treatment study of eight asthmatics suggests that either the protective effect of verapamil is variable among subjects or a preceding histamine inhalation test blocks the verapamil effect.
Ipratropium bromide bronchodilator solution.
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Combination bronchodilator therapy in asthma.
This study has compared the short-term bronchodilator effects of inhaled anticholinergic (ipratropium bromide) and sympathomimetic (fenoterol) agents alone and in combination in 18 asthmatic patients. the study was of double-blind, placebo-controlled, crossover design. The combination of 60 micrograms ipratropium bromide and 200 micrograms of fenoterol had a greater bronchodilator effect than lower dose combinations or either drug alone. Small but significant gains may be made with combination inhaled bronchodilator therapy.
Staff ratings of elderly at day care centers: mental status, hypochondriasis, depression.
Staff at two day care centers for the frail and/or impaired elderly rated participants (N = 33) for mental status, hypochondriasis and depression. The ratings were correlated with the MSQ, HSIG and GDS. The results indicated a significant correlation (P less than .001) between staff ratings and the MSQ. The correlations between other staff ratings and the respective tests were quite low. It was concluded that staff ratings for depression and hypochondriasis were not valid or reliable unless the staff member had done a structured intake.
Bronchial smooth muscle tone in normal subjects.
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Evaluation of lyophilized heparin syringes for the collection of arterial blood for acid base analysis.
The effects of liquid heparin on the analysis of acid/base status of arterial blood include a reduction in PCO2 and an increase in PO2. A study was performed to compare a lyophilised heparin syringe with a liquid heparin glass syringe for collection of blood for acid/base analysis. No significant difference between the variables measured in blood taken in the two syringes was demonstrated.
A multiple-choice quiz board for health education.
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Precise measurement of fluid administration in hemodynamic monitoring.
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Clinical evaluation of a new critical care nurse.
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