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Biomedical subjects

E Mazeman

Publications and source records attributed to E Mazeman.

At least 73 records · Page 4Linked to original sources
PubMed1990

[Efficacy of Pygeum africanum extract in the medical therapy of urination disorders due to benign prostatic hyperplasia: evaluation of objective and subjective parameters. A placebo-controlled double-blind multicenter study].

The efficacy of an extract of Pygeum africanum in the treatment of micturitional disorders due to benign prostatic hyperplasia was tested in a multicentre double-blind trial versus placebo. Capsules containing 50 mg of Pygeum africanum extract or placebo were administered at a dosage of 1 capsule in the morning and 1 capsule in the evening over a period of 60 days. 263 patients were included in this study, which was carried out in 8 centres in Germany, France, and Austria. Evaluation was mainly based on quantitative parameters such as residual urine, uroflowmetry and the precise monitoring of diurnal and nocturnal pollakiuria. Treatment with the Pygeum africanum extract led to a marked clinical improvement: a comparison of the quantitative parameters showed a significant difference between the Pygeum africanum group and the placebo group with respect to therapeutic response. The characteristic subjective symptoms of micturitional disorders, which were evaluated by the patients in a qualitative manner, were also significantly improved by administration of Pygeum africanum extract. Overall assessment at the end of therapy, showed that micturition improved in 66% of the patients treated with Pygeum africanum extract, as compared with an improvement of 31% in the placebo group. The difference was significant at the statistical level of p less than 0.001. During therapy with Pygeum africanum extract, gastrointestinal side effects occurred in 5 patients. Treatment was discontinued in three of those cases.

Double-Blind Method↗
PubMed1990

[leiomyoma of the bladder. Apropos of a case].

Leiomyomas are the most common form of benign mesenchymal bladder tumour. While the diagnosis may be suggested on radiological investigations, it can only be confirmed by histology. The prognosis is good, the treatment being exclusively surgical.

Adult↗
PubMed1989

[Apropos of 2 cases of oculo-orbital metastases of a prostatic epithelioma].

The authors report one case of choroid metastasis and one case of orbital metastasis from a prostatic carcinoma. A review of the literature confirms the exceptional nature of these metastatic sites (28 cases), which constitute a poor short-term prognostic factor. Palliative hormonal treatment allows regression of the ophthalmic signs without modifying the course of the disease.

Aged↗
PubMed1989

[Treatment of superficial bladder tumors using the argon laser].

The authors report their experience of Argon laser in superficial bladder cancer (332 tumors in 106 patients). The advantages are: unneeded anesthesia, ambulatory treatment, absence of bleeding, no gaz, no obturator nerve stimulation, limited focal reaction and unlikely complications. The disadvantages are: duration of treatment, limited pathological material (with cold cup biopsy). The limitations are: size of the tumor (less than or equal to 1 cm) and a location in an area that can be reached perpendicularly. This kind of treatment does not seem to reduce the recurrence rate.

Argon↗
PubMed1988

[Nonseminomatous testicular tumors. Diagnostic strategy. Apropos of 53 cases].

The authors define a diagnostic strategy designed to establish the most reliable clinical staging on the basis of a series of 53 cases non-seminomatous testicular tumours. The value of each complementary laboratory and radiological examination is analysed in terms of its performance and its morbidity and a selective staging procedure is proposed. Finally, the role of retroperitoneal lymphadenectomy is discussed, as it appears that, with the development of chemotherapeutic protocols, this procedure will gradually disappear from the staging of early tumours to become an essentially therapeutic procedure. However, lymphadenectomy is still part of the authors' current staging protocol for clinical stage I tumours as it remains the only way to define the extension of the tumour with certainty.

Biomarkers, Tumor↗
PubMed1987

[The Whitaker test. Apropos of an obstacle not to be ignored].

Since 1980, 35 pyelomanometric procedures have been performed in the Department of Clinical Urology for dilatations of the upper urinary tract of uncertain etiology. During two recent procedures, pressure measurements were modified by an extra-urinary obstacle caused by the patient's position. Our experience confirms the value of the Whittaker test as well as the need for a faultless technique.

Adult↗
PubMed1987

[Intracavernosa injections of drugs in erection disorders. Their clinical value apropos of 100 cases].

Several centers of interest have been stimulated by the true progress represented by the use of intracavernous injections (ICI) for disorders of erection. First, we have become conscious of our uncertainties concerning the physiology of erection. Second, they serve to orientate the etiologic diagnosis and prognosis when positive responses are obtained in cases of impotence. Third, they are of therapeutic interest as auto-injections in impotence with, however, the risk of secondary cavernous fibrosis. Lastly, they represent a new treatment for priapism. However, these ICI procedures are still in the experimental stage, and should be used with some caution because of their potential morbidity and unknown long-term effects.

Erectile Dysfunction↗
PubMed1986

[Vesicorenal reflux following endoscopic treatment of vesical tumors. Developmental and therapeutic complications].

A survey of 107 patients treated for bladder papillomatosis, 78 of which recurred, confirmed the frequency of appearance of an iatrogenic reflux (28 cases: 26%). The main explanations for its onset are resection and orificial sclerosis. Two consequences of reflux are discussed. One is very probable: the development of tumoral lesions in the upper excretory pathways. Noted in 7 (25%) of the 28 cases, these high tumors can be partly explained by the mechanism of cell implantation, grafts being ascending in cases of reflux. A relation between severity of reflux and site of secondary tumor was not found (6 unilateral and 1 bilateral tumor). This was also true for the effect of the bladder lesion stage on frequency of high localizations. The second possible consequence of reflux, the subject of much greater debate, concerns the increased risk of toxicity from local chemotherapy which could lead to increase in the time and area of contact. This risk appears to be very low (2 interruptions of therapy in 10 patients treated with Thiotepa, none with mitomycin). Diagnosis of reflux affects treatment of the bladder tumor. When reflux is associated with high lesions, treatment of the tumor is the first imperative and is dependent on the manner in which it is conceived. When reflux is isolated, its surgical correction with the aim of preventing development of a pyelo-ureteral tumor is not widely accepted, since the condition of the patient and the course of the bladder disease must be taken into consideration.

Aged↗
PubMed1986

[Computerized tomography in evaluating the extension of bladder tumors. 215 cases].

CT scan imaging was used to explore 215 cases of bladder tumor (48 A-B1, 55 B2, 85 C, 27 D), and findings compared with those at operation and on histopathology of specimens after total cystectomy (141 cases), partial cystectomy (13 cases) or endoscopic resection (61 cases). The radiologic technique used was that of natural contrast, evaluating the negative contrast of intravesical urine in relation to the normal or pathologic bladder wall. Analysis of scan sections, assisted by a previous pathologic and radiologic study of 14 transverse sections of pelvis, allowed definition of a certain number of semiologic criteria corresponding to the various stages of the disease. Results showed global reliability to be relatively satisfactory for assessment of local and regional extension (85%): it was obviously a more effective investigation for tumors of low invasion (A-B1: 75%, B2: 81%) than for widely infiltrating tumors (C: 94%, D: 93%). Glandular extension was less reliably evaluated, however, since global efficacy was only 65%. Failures observed can be explained by the frequent small size of the metastatic glands, the poorness in cellular and fatty tissues and, particularly, by the fact that the scanner provides data of size of glands only and not on their internal architecture. The place of the scanner among other paraclinical methods of evaluating tumoral extension has still to be determined.

Humans↗