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Biomedical subjects

E Martin

Publications and source records attributed to E Martin.

At least 703 records · Page 39Linked to original sources
PubMed1975

[Improvement of parenteral feeding through the additional administration of a serum protein solution].

On 7 days - 5 postoperative - patients undergoing Billroth I or Billroth II were continuously infused apparatively witn an amino acid mixture of 100% and a glucose-xylitol-solution of 25% (group I). One group (group II) additionally received a serum protein solution. From the first preoperative day to the fifth day of the postoperative period we determined individual parameters in blood and urine. A decrease of serum phosphate level beginning on the first day after starting parenteral nutrition was observed. In the nitrogen balances, in total protein and albumin concentration there were no differences, but serum gamma-globulin concentration of group II was very low at the end of the parenteral nutrition period, a point which at present cannot be explained.

Blood Proteins↗
PubMed1975

Conversion of covalently mercurated nucleic acids to tritiated and halogenated derivatives.

Mercurated nucleic acids are converted to the corresponding tritiated, brominated, and iodinated derivatives by treatment with sodium borotritiide, N-bromosuccinimide, and elemental iodine, respectively. All three reactions occur under mild conditions in neutral aqueous solutions. Mercury-halogen conversions are essentially quantitative at both the mono- and polynucleotide levels. Tritiation reactions also proceed efficiently with mononucleotides, although polymers undergo incomplete demercuration. In spite of the latter limitation , these reactions provide novel and efficient synthetic routes to radiolabeled nucleic acid derivatives.

Borohydrides↗
PubMed1975

[Segmental replacement of the prinicipal extra-hepatic bile duct in the dog using a silicone elastomere prosthesis].

The authors present an experimental series of prosthetic replacement of the common bile duct in the dog. The material used was silicone elastomere. In all the dogs studied, a new bile duct became formed around the prosthesis consisting of a fibrous tube covered with mucosa. The follow-up period in the first group of operated dogs was more than 2 1/2 years and in most dogs studied, there was neither biliary cirrhosis nor cholestasis. These encouraging results led the authors to suggest the operation in humans, particularly in carcinoma of the bile ducts.

Animals↗
PubMed1975

[The effect of various electrolyte solutions on the water and electrolyte balance during the postoperative phase].

Investigations with 3 electrolyte solutions having different qualitative and quantitative compositions were carried out to see their effect on the physiological equilibrium in the pre, intra- and postoperative phases in patients who had to undergo moderately severe surgery. On the basis of electrolyte and osmolarity determinations in serum and 24-hour urine, blood gas analyses, determinations of hemoglobin and hematocrit, 24-hour volume and specific weight of the urine, it was possible to establish an electrolyte administration adapted to the pre-, intra- and postoperative condition of the patients. By the infusion of a solution with this electrolyte content it was possible to keep the measured parameters within the normal range throughout the entire period of measurement before, during and after the operation.

Acid-Base Equilibrium↗
PubMed1975

[Determination of the closing volume and its value in the early detection of chronic obstructive lung disease].

The determination of the closing volume appears as a good test for the early detection of obstructive lung diseases and of disorders in the ventilation distribution. Easy to perform, its use should become extensive. To make use of this investigation under the better possible conditions, it is strictly necessary to respect methodologic norms and an excellent technology and to be aware of some morphologic anomalies in the curves.

Age Factors↗
PubMed1975

[The reaction of the cardio-circulatory system during the introduction of the modificated NLA (AUTHOR'S TRANSL)].

The hemodynamic effects of Etomidate are examined during the introduction of a modificated NLA. The following parameters are registrated: Heart Rate, Arterial and Mean Arterial Pressure, Pulmonary and Mean Pulmonary Pressure, and Cardiac Output. The Total Periphere Resistance and the Tension-Time-Index are calculated. Apart from a short moment during and immediately after intubation a remarkable constancy of all parameters is found. The alpha-receptor-blocking effect of Etomidate and DHB and the resulting decrease of the Total-Periphere Resistance are compensated by infusion of a colloidsolution. Myoclonias are not observed. Etomidate may be regarded as a drug with few effects on the circulation. It may be thinkable, that by means of Etomidate even in shock a careful introduction is possible.

Adult↗
PubMed1975

[Circulatory changes during preoperative isovolaemic haemodilution with a mixed solution of hydroxyethyl starch and 5% human albumine. A clinical study (author's transl)].

The influence of preoperative isovolaemic haemodilution on the circulation was examined in a clinical study. Heart rate, mean arterial pressure, mean pulmonary arterial pressure, cardiac output as well as haemoglobin and haematocrit values were determined. Stroke volume, total peripheral resistance, and the modified tension-time-index were calculated. A mixture of human albumin 5% and hydroxy-ethyl-starch was used as a solution for dilution. During the dilution phase the cardiac output increased compensatorily to the decrease of haemoglobin and the haematocrit values. While the heart rate and the mean arterial pressure remained unchanged the total peripheral resistance was reduced. Considering the described conditions and contraindications, preoperative isovolaemic haemodilution is a suitable method to replace an intraoperative blood loss of up to 2000 ml autologously. Thus a posttransfusion hepatitis can be avoided. In addition, preoperative isovolaemic hemodilution improves the microcirculation and may have a prophylactic effect on the thrombosis in the postoperative phase.

Blood Circulation↗
PubMed1975

[Metabolic behavior in total parenteral nutrition during the postoperative phase].

In patients who had undergone gastric operation, total postoperative parenteral nutrition was effected using a combination of two infusion solutions having complementary constituents. 80 g L-amino acids and about 2,500 kcal in the form of a glucose-levulose-xylitol mixture together with electrolytes and trace elements were infused daily. Metabolic parameters, serum levels and the concentrations of the most important administered substances excreted in the urine were determined every day at the same time. The 1:1:1 glucose-levulose-xylitol ratio of the caloric carrier proved to be a favourable combination with respect to metabolic behaviour and the necessary daily supply of calories. The basic electrolyte requirement of the patients was to a large extent met by the quantities contained in the solutions.

Acid-Base Equilibrium↗