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Biomedical subjects

E Marmo

Publications and source records attributed to E Marmo.

At least 163 records · Page 9Linked to original sources
PubMed1981

Ester of 6-cis-dialkylamino-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ol with hypotensive and other activities.

Three series of esters of 6-cis-dialkylamino-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ol (dialkylamino = pyrrolidino, piperidino, morpholino) are described. A number of these compounds showed strong hypotensive activity in rats, as well as infiltration anesthesia and antiarrhythmic activity in mice. The lowering effects on heart rate in rats are also described.

Anesthetics, Local↗
PubMed1980

Derivatives of 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2]nonane with antiarrhythmic, local anesthetic and hypotensive activities. I.

The synthesis of three series of 3-acyl-, 3-alkyl- and 3-dialkylaminoacetyl-5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2]nonanes, (III), (IV) and (V), respectively, is described. A number of these compounds showed surface anesthesia in rabbits and infiltration anesthesia in mice, and antiarrhythmic activity in guinea pigs and mice, all effects being superior or similar to those of lidocaine. The circulatory, cardiac and respiratory effects in dogs and hens are also described.

Anesthetics, Local↗
PubMed1980

Intracarotidal injection of beta-adrenergic blocking agents: variations in the carotid sinus baro- and chemoreceptor activity.

The intracarotidal injection of some bet-adrenergic blocking agents (dl-acebutolol, dl-, l-, d-alprenolol, dl-bunitrolol, dl-buthoxamine, dl-, l-, d-INPEA, dl-Ko 592, dl-metoprolol, dl-oxprenolol, dl-propranolol, dl-tolamolol) in anesthetized and bivagotomized dogs reduced the arterial blood pressure and the baro- and chemoreceptor activity. These effects seem to be mediated by an interaction with central nervous, cardiovascular and respiratory structures dependent on the carotid arteries and by a direct interference of these drugs with the carotid sinus baro- and chemoreceptor structures. Moreover, these effects were not a result of the beta-adrenolytic properties of the drugs.

Adrenergic beta-Antagonists↗
PubMed1980

Narcosis, blood glucose, plasma insulin and renin concentrations: experimental research with Althesin, thiopental and ketamine.

In the rat, narcotic doses of Althesin injected intraperitoneally did not modify blood glucose concentration nor plasma insulin concentration. On the contrary, a reduction of blood glucose concentration, associated with an increase of plasma insulin concentration was observed when narcotic doses of thiopental and ketamine were administered. Plasma renin concentrations decreased after injection of Althesin and thiopental but increased after injection of ketamine.

Alfaxalone Alfadolone Mixture↗
PubMed1980

Antagonism by classical antiepileptics and sodium valproate of cefazolin in induced experimental epilepsy in rats.

The effects of cefazolin, a semisynthetic cephalosporin, on rat behavior, electrocortical activity and on electrocortical spectrum power were evaluated. In addition, the possible antagonism by some antiepileptic agents was studied. Cegazolin, given intravenously in rats, produced generalized convulsions, electrocortical high-voltage spikes and other electrocortical abnormalities similar to those described to occur in human epilepsy. Power spectrum analysis of the electrocortical activity revealed a significant increase in total voltage output during electrocortical epileptogenic discharges. In addition high-voltage spikes induced by cefazolin were easily counted and lasted approximately 90 min. Classical antiepileptic drugs (diphenylhydantoin, phenobarbital and clonazepam as well as sodium valproate were able to counteract electroclinical disorders induced by cefazolin.

Animals↗
PubMed1980

Effects of intraventricular beta-endorphin and D-ALA2-methionine-enkephalinamide on behaviour, spectrum power of electrocortical activity and body temperature in chicks.

In chicks (Gallus domesticus) the effects of beta-endorphin and D-Ala-2-methionine-enkephalinamide given into the third cerebral ventricle on behaviour, electrocortical activity and body temperature were studied. Dose-dependent behavioural stuporous state, decrease in painful stimuli and hypothermic effects were observed after both peptides. Electrocortical high-amplitude slow frequency waves occurred during behavioural sedation and stupor. Spectrum power analysis has allowed to quantify the ECoG activity and has revealed an increase in total voltage output with a predominant increase within the lower spectrum frequencies. The hypothermic effects were significantly more marked when chicks were kept at ambient temperature below their thermoneutral range. Behavioural, electrocortical and body temperature effects were rapidly reversed by naloxone showing that these effects are mediated through an activation of specific opioid receptors.

Animals↗
PubMed1980

Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2,2,2]octan-5-trans-ol with antiarrhythmic and other activities. V.

A series of N,N-dialkyl 5-trans-carbamoyloxy-1,2,3,3-tetramethyl-2-azabicyclo [2,2,2]octanes was prepared by reaction of 1,2,3,3-tetramethyl-2-azabicyclo [2,2,2]octan-5-trans-ol with phosgene, followed by aminolysis of the resulting chlorocarbonate with aliphatic secondary amines. 5-Chloro-1,2,3,3-tetramethyl-2-azabicyclo [2,2,2] octane (cis/trans mixture) was isolated as by-product of the reaction. A number of urethanes showed antiarrhythmic activity in guinea pigs and mice, as well as surface anesthesia in rabbits and infiltration anesthesia in mice, superior or similar to lidocaine. The circulatory, cardiac and respiratory effects in dogs and hens are also described.

Anesthetics, Local↗
PubMed1980

Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-trans-ol with antiarrhythmic and other activities. III.

A new series of aliphatic and aromatic esters of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-trans-ol is described. A number of these compounds showed antiarrhythmic activity in guinea pigs and mice, as well as surface anesthesia in rabbits and infiltration anesthesia in mice, superior or similar to that of lidocaine. The circulatory, cardiac and respiratory effects in dogs and hens are also described.

Anesthetics, Local↗