[Phosphorylcholine and cell membranes].
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Biomedical subjects
Publications and source records attributed to E Marmo.
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The occlusion of bile duct reduced the microsomal cytochrome P-450 activity in the liver of rats. However, the effects of the inducer drug, phenobarbital, were not abolished.
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In vivo and in vitro experiments showed that Verapamil dilates the coronaries, prevents coronary spasm, produces Ca++-antagonism, offers protection against myocardial necrosis, prevents arrhythmia, reduces pressure, increases the purinergic reactivity and produces inhibition of platelet aggregation. It was devoid of competitive-adrenolytic activity in the heart and vessels. A methoxy derivative of the drug (D-600) had a negative inotropic and chronotropic action and was more hypotensive than Verapamil.
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Tibric acid shows interesting hypocholesteremic and hypolipemic activity greater than that of clofibrate. In addition high concentrations of tibric acid affect platelet aggregation. Tibric acid does not show choleretic activity and does not affect liver function.
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