Semeiological detection of bronchiogenic cancer: the limitations of exploratory thoracotomy.
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Adult↗
Biomedical subjects
E Mariani
Publications and source records attributed to E Mariani.
In vitro cytolytic activity of human NK cells against osteosarcoma cell lines.
NK lymphocytes present CD16, CD56 and lack CD3 surface molecules and are able to spontaneously lyse tumor or virus infected cells. In this study we evaluated the susceptibility of some human osteosarcoma cell lines to NK cytolytic activity and standardized the assay conditions. NK lymphocytes were used as effector cells in a cytotoxicity test against HOS, U-2 OS and Saos-2 osteosarcoma targets. While HOS cells were susceptible on the contrary U-2 OS and Saos-2 were osteosarcoma resistant lines. Our preliminary results support a model for the study of a possible interaction between the immune system and these tumors.
Bone Neoplasms↗
Lytic activity of IL-2 and IL-12 stimulated NK cells against HOS osteosarcoma cell line.
NK cells are CD16, CD56 positive lymphocytes that spontaneously lyse tumor or virus infected cells. In this study we investigated whether IL-2 and/or IL-12 stimulated NK cells increased their lytic efficiency against HOS osteosarcoma cell line. Our results demonstrate that both 18 hour and 5 day incubation times enhanced the lytic activity of human PBL against HOS and K562 target cells and that IL-12 appears to be more efficient than IL-2 in augmenting NK cytotoxicity.
Adult↗