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Biomedical subjects

E Mampel

Publications and source records attributed to E Mampel.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Early symptoms of hyperparathyroidism in nephropathies].

The development of an autonomous (tertiary) hyperparathyroidism in patients with renal diseases must clinically be taken into consideration, when by therapeutic measures the causes of a compensatory overfunction of the parathyroid glands were excluded, but the symptoms of a hyperparathyroidism continue or even increase. This is of special importance in the control of patients with renal grafts. The increase of the serum calcium on more than the normal value in simultaneously increased serum phosphate level and increased activity of the alkaline bone phosphatase in connection with demineralisation of the skeleton, osteoclastic changes of the bones and estraossary calcifications may be regarded as early symptoms of a hyperparathyroidism. It is to be discussed the hypothesis, whether in every autonomous hyperparathyroidism a regulative reaction precedes. In patients with renal diseases in a limited number a prevention of the regulative overfunction of the parathyroid glands is possible by an early compensation of a calcium deficit (acquired vitamin D resistance), a hyperphosphataemia and a renal acidosis.

Adenoma↗
PubMed1977

[Significance of the determination of serum and urinary creatinine for the clinical use, dispensatory care and screening of patients with kidney diseases].

In the early recognition, control of course and therapy of patients with chronic renal diseases the proof of disturbances of the renal functions has a particular value. Here the determination of creatinine in the serum and in the urine increasingly gains significance, since an automatisation stood the test. The creatinine values may be used as orientation values for the clearance method in the dispensary or in the screening as well as in the sense of reference values for other substances normally contained in the urine. In patients with chronic renal diseases a shift of the daily variation of the renal function according to the development of a nycturia is to be observed still before the formation of an isosthenuria. In female test persons the excretion of creatinine is on an average lower than in male ones. This may be based on the differently developed muscle masses. When creatinine is used as reference value for other substances the dependence on age and sex must be taken into consideration in the case that the substance concerned does not reveal the same age- and sex-specific course of behaviour.

Circadian Rhythm↗
PubMed1977

[Penicillamine-induced glomerulonephritis].

In 6 of 24 courses of a disease a nephrotic syndrome appeared under the application of penicillamine. An acute renal failure with exitus letalis developed under the penicillamine therapy of a scleroderma. In the treatment of a mercurial poisoning by penicillamine the nephrotic syndrome increased to a proteinuria of 50 g/24 hours which receded after discontinuation of the remedy. In one group of patients with chronic pyelonephritis could be demonstrated that penicillamine in a primarily damaged kidney must not lead to a secondary glomerular lesion. These findings led to the conclusion that in the appearance of a proteinuria under penicillamine a strong observation of the renal function is necessary, if a continution of the therapy is given from vital indication.

Acute Kidney Injury↗