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Biomedical subjects

E Malberger

Publications and source records attributed to E Malberger.

At least 37 records · Page 2Linked to original sources
PubMed1990

Symptomatic pericardial effusion in lung cancer patients: the role of fluid cytology.

During the years 1975-1988, twenty lung cancer patients with symptomatic pericardial effusion were treated conservatively at our center. Echocardiography demonstrated small pericardial effusion in 2 patients, medium size effusion in 3 patients and large amount of fluid in 15 patients. Fifteen patients developed cardiac tamponade; in three of these patients, this was the presenting manifestation of lung cancer. Pericardiocentesis resulted in prompt, though temporary, symptomatic relief in all patients. Fluid cytology demonstrated suspected malignant cells in 2 patients and malignant cells in 13 patients. Based on cytology, the diagnosis of adenocarcinoma was established in six patients, small cell carcinoma in three patients, and epidermoid carcinoma in one patient. All patients were dead within 9 months from the time of diagnosis of pericardial effusion; 17 died within less than 3 months. It is concluded that pericardial effusion in lung cancer is indicative of rapid tumor progression and short survival. Fluid cytology provides an immediate and accurate means of diagnosis.

Aged↗
PubMed1990

Symptomatic pericardial effusion in breast cancer patients: the role of fluid cytology.

Clinical and cytologic findings in 21 breast cancer patients with symptomatic pericardial effusion are presented. The etiology of the pericardial effusion was definitely malignant, by cytology/histology in 13 patients (62%), and suspected malignant by cytology in 2 patients (9%). One patient (5%) with definitely nonmalignant pericardial effusion by cytology was found to be histologically positive at autopsy. In 5 patients (24%) there was no histological/cytological evidence of malignancy; radiation pericarditis could be the etiology in 4 of these 5 patients. The median time from the diagnosis of breast cancer to the development of symptomatic pericardial effusion was 60 months (range: 1-219 months). Ten patients developed cardiac tamponade; they were treated by either pericardiocentesis or pericardiectomy. The mean survival of patients with negative cytology/histology was 12 months; patients with suspicious cytology had a mean survival of 9 months; patients with malignant effusion, treated by pericardiectomy, had a mean survival of 22.3 months, while patients with malignant pericardial effusion, who were not subjected to surgery, had a mean survival of 4.7 months, only. It is concluded that the etiology of symptomatic pericardial effusion in breast cancer patients is not always malignant, which emphasizes the role of fluid cytology in establishing definite diagnosis. The survival probability is a function of the extent of extracardiac disease; among patients with malignant pericardial effusion those selected for pericardiectomy have a longer than average survival.

Adult↗
PubMed1990

Liver histology and cytology in the diagnosis of malignant liver disease.

Histologic and cytologic preparations from the saline rinsings of the Menghini biopsy were obtained from 193 patients with a variety of liver diseases. The results were analyzed to determine the sensitivity, specificity, and overall accuracy of the histologic, cytologic, and of the two combined methods. Thirty-four patients had malignant liver disease (MLD), whereas 159 patients had no evidence of MLD. Malignant neoplasms were detected by cytology alone in five patients, by histology alone in 15 patients, and by both histologic and cytologic findings in six patients. Liver cancer was not diagnosed by both methods in eight patients. The sensitivity of the cytologic, histologic, and combined cytologic and histologic results for detecting malignancy were 32.4%, 61.8%, and 79.4%, respectively, whereas the specificity was 100% for all methods. The overall accuracy was 88.1%, 93.2%, and 95.5%, respectively. This study demonstrates that cytologic examination of the fluid obtained by liver needle biopsy (LNB) has a high specificity and low sensitivity that increased the diagnostic yield of histology alone for detecting MLD by 14.7%.

Adenocarcinoma↗
PubMed1989

[Cytological examination of fine needle aspirates of supraclavicular lymph nodes].

In 170 of 244 fine needle aspiration biopsies of suspicious supraclavicular lymph nodes performed over the course of a decade, the medical records were available for study. In 67 cases aspirations were by the staff of the Cytological Department, while 103 were by the ward and clinic physicians. Among the former about 6% were nonrepresentative, and among the latter 32%. In all cases in which a cytological diagnosis of malignancy was made, it corresponded either to the available histological diagnosis or to the final diagnosis. In all cases with a benign cytological diagnosis, either the available histological diagnosis or the long term follow-up was in accord. The malignant lymph nodes aspirated drained regional as well as distant tumors. 82% (23/28) of the malignant nodes draining distant tumors were on the left side.

Biopsy, Needle↗
PubMed1989

[Is Solcoderm suitable for treating malignant skin tumors?].

Solcoderm, a liquid preparation developed in the USSR, is recommended for topical treatment of benign and malignant skin tumors. We present 5 out of 25 patients treated in our department over the past 2 years who had been treated with Solcoderm for malignant skin tumors. The preparation appeared to have affected only the superficial layers of the tumor and had not penetrated in depth. Cellular remnants tended to spread far beyond the confines of the original tumor and seemed to become much more aggressive. To be effective, the technique of applying the drug would have to be much more complicated than originally specified. Both the functional and esthetic results are much worse than expected.

Acetates↗
PubMed1987

Leptomeningeal involvement by epithelial ovarian carcinoma: a case report.

A patient with epithelial ovarian carcinoma, who developed meningeal carcinomatosis, is hereby presented. A review of the literature revealed that only a few cases of this entity have been reported. With the prolonged survival of ovarian cancer patients treated by combination chemotherapy, it is expected that meningeal involvement will be found more often.

Cystadenocarcinoma↗
PubMed1985

Diagnostic accuracy of thyroid aspirative cytology in view of cumulative experience.

Cytological findings of 100 fine-needle aspirations from thyroid nodules of 83 patients were reviewed and correlated with histological or clinical diagnoses. Diagnostic accuracy of inflammatory lesions, papillary carcinomas and nonfollicular tumors was very high and did not alter significantly after reexamination. The diagnostic accuracy of proliferative follicular lesions improved considerably with experience. There was some overlap in the diagnosis of follicular adenomas and goiters; we did not differentiate between follicular adenomas and carcinomas, both of which were reported as follicular tumors, but all cases of follicular carcinoma were diagnosed as follicular tumors, thus warranting biopsy.

Adenocarcinoma↗
PubMed1984

Pancoast's syndrome in multiple myeloma.

A 74-year-old patient developed IgG multiple myeloma. 7 months later a right Pancoast's syndrome was observed. Computerized tomography established the extrapleural origin of the tumor. Fine needle aspiration revealed pathological plasma cells. Partial reduction of plasmacytoma was noted following radiotherapy, but the patient succumbed to pneumonia. Autopsy confirmed that a plasmacytoma caused the Pancoast's syndrome. The importance of early diagnosis and accurate therapy of this rare manifestation of multiple myeloma is discussed.

Aged↗
PubMed1984

Rare complications after transabdominal fine needle aspiration.

Fine needle aspiration is emerging as a useful diagnostic tool in the evaluation of tumor masses. This technique provides high diagnostic yield associated with only minimal side effects. Of 500 transabdominal aspirations conducted in our hospital over an 8-year period we have experienced four cases of unusual complications after this procedure. These included bile peritonitis, localized peritonitis and infection, perforation of small bowel, and pneumothorax. The last three cases have not yet been described in the literature as complications of transabdominal aspiration. Analysis of these complications illustrate the importance of careful patient selection and meticulous attention to the proper procedure.

Aged↗