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Biomedical subjects

E Majchrowicz

Publications and source records attributed to E Majchrowicz.

49 records · Page 3Linked to original sources

Blood concentrations of acetaldehyde and ethanol in chronic alcoholics.

Fifteen adult male alcoholic volunteers were studied before, during, and after a 10- to 15-day period of experimentally induced intoxication. Blood acetaldehyde concentrations ranged from 0.11 to 0.15 and from 0.04 to 0.08 milligrams per 100 milliliters when blood ethanol concentrations ranged from 1 to 400 milligrams per 100 milliliters after consumption of bourbon or grain ethanol, respectively. No dose or dose-time relationships were found between blood ethanol concentrations and blood acetaldehyde concentrations during any phase of this study.

Acetaldehyde↗

Regional differences in high-affinity choline uptake in brain after acute and chronic treatment with ethanol.

A single dose of ethanol has been shown to affect both striatal and hippocampal high-affinity choline uptake. This effect is probably mediated through effects of ethanol on acetylcholine release. Choline uptake has also been shown to be altered in ethanol-dependent animals, and these effects may be coupled to alterations in dopamine neurons which are produced by chronic ethanol feeding and withdrawal.

Acetylcholine↗