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Biomedical subjects

E Macotela-Ruíz

Publications and source records attributed to E Macotela-Ruíz.

9 recordsLinked to original sources
PubMed1976

Occupational pigmented contact dermatitis from Naphthol AS.

Hyper-pigmentation as a manifestation of contact sensitivity to optical brighteners has previously been reported. In 1973 we observed an epidemic of pigmented contact dermatitis occurring in a textile mill in connection with the manufacture of drill fabrics impregnated with a recently introduced azo dye coupling component Naphthol AS. Of the 53 workers included in the study, 12 presented a spotted pattern of hyperpigmentation mainly affecting the exposed areas, but without pruritus, 18 were pigmented to a lesser degree, and in 21 it was not possible to discern any well-defined discoloration; some of the patients in the last group, however, complained of slight pruritus. The last two patients who were fair-skinned showed a reddish-brown pigmentation and a well pronounced pruritus. Hyper-pigmentation was most pronounced in individuals with dark complexions, whereas fair-skinned patient also showed "classical" eczematous symptoms including pruritus. A field study demonstrated direct exposure to the chemical. All 53 patients were patch-tested with Naphthol AS 5% in water, and 24 were found to be positive. Histological features were melanocyte proliferation, incontinence of pigment, and various degrees of damage to the basal layer.

Anilides↗
PubMedDate not supplied

[Otomycosis].

From 163 patients with clinical diagnosis of otomycosis, only 72 were confirmed by the mycological laboratory. No difference was noticed regarding the age and sex of patients. The clinical symptoms were the break of the timpanic membrane, secretion and fungal colonies in one side. Most of our patients had more than one year of evolution. The more common causative agent was Aspergillus and quite frequently it were present non-pathogenic bacteria. The local treatment with a solution containing vioform with salicilic acid was successful in the 82% of cases.

Adolescent↗
PubMedDate not supplied

[The treatment of scabies with oral ivermectin].

To evaluate the efficacy and safety of a single 200 mcg/Kg dose of ivermectine as compared with placebo in the treatment of scabies was settled. Fifty five patients with the diagnosis of scabies were randomized to a single oral dose of ivermectine or placebo. The study informed that 26 (79.3%) patients were cured with ivermectine on their first follow-up visit, as compared to only four (16%) in the placebo group (X2 = 77.07, p < 0.001). Overall, 37 of 50 (74%) patients treated with ivermectine cured, as compared to only four of 26 (16%) treated with placebo, this difference was still significant (X2 = 23.66, p < 0.001). We concluded that ivermectine is a safe and effective treatment for scabies.

Administration, Oral↗