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Biomedical subjects

E Macdonald

Publications and source records attributed to E Macdonald.

30 records · Page 2Linked to original sources
PubMed1986

Dual infection of the toe web caused by Trichophyton rubrum and Microsporum canis.

A case of tinea pedis caused by a dual infection with Trichophyton rubrum and Microsporum canis is reported. It is of particular interest because infections of the toe webs caused by M. canis are uncommon and the combination of T. rubrum and M. canis has not been reported. In addition, a marked difference in response to treatment with an imidazole (bifonazole) was observed.

Adult↗
PubMed1985

Actinomycetoma caused by Nocardiopsis dassonvillei.

We report a case of mycetoma caused by Nocardiopsis dassonvillei in a 39-year-old man. He had multiple nodules and draining sinuses on the anterior aspect of his right leg just below the knee. Few cream-colored granules were seen in the exudate. The biopsy specimen showed gram-positive, non-acid-fast granules with distinct borders. An aerobic actinomycete isolated from the lesion was identified as N dassonvillei. We think that this is the first reported case of mycetoma caused by N dassonvillei.

Actinomycetales↗
PubMed1982

Experimental necrotic dermatosis induced by group G streptococci in mice.

Self healing necrotic lesions were produced on the backs of laboratory mice by injecting group G streptococci into the skin. The incidence and severity of necrotic dermatosis was dose related. When 1 x 10(1) colony forming units (cfu) were injected subcutaneously, lesions developed on three of 16 mice 4 days post inoculation. Injection of 1 x 10(3) cfu produced lesions on five of 16 mice and 1 x 10(5) cfu produced lesions on seven of 15 mice 3 days post inoculation. An inoculation of 1 x 10(7) cfu produced lesions on all of 16 mice 2 days post inoculation. Lesions produced by the 1 x 10(1) inoculum were smaller and had healed by the 15th day post inoculation, whereas lesions produced by the 1 x 10(7) inoculum persisted until the 24th day post inoculation. No mortality could be attributed to experimental design and all lesions healed without the use of medication or antibiotics.

Animals↗
PubMed1978

Comparison of radiotherapy with and without razoxane (ICRF 159) in the treatment of soft tissue sarcomas.

Comparison of the recurrence rates of soft tissue sarcomas treated by radiotherapy (14 patients) or radiotherapy and synchronous administration of razoxane (19 patients) has shown a statistically significant benefit for those patients treated by the combination. No increase in tissue reactions or adverse side-effects (apart from a readily reversible leukopenia) was observed. The implication is that razoxane acts as a well tolerated adjuvant for radiotherapy.

Adult↗