Search PubMed⌕ Search

Biomedical subjects

E M Williams

Publications and source records attributed to E M Williams.

At least 109 records · Page 6Linked to original sources
PubMed1967

Chemosensitivity of cardiac muscle.

1. Measurements of contractions, conduction velocity and intracellular potential were made on isolated rabbit atria under four sets of conditions: high bicarbonate/high CO(2) (HH), low bicarbonate/low CO(2) (LL), high bicarbonate/low CO(2) (HL) and low bicarbonate/high CO(2) (LH). The ratio high/low was the same for the bicarbonate and CO(2) concentrations, so that HH had the same pH as LL.2. Acid solutions caused a fall of a few mV in the resting potential, but not in the overshoot. They reduced conduction velocity and rate of rise of the action potential. They depressed contractions, but prolonged the tail of the action potential.3. Alkaline solutions caused the converse changes, but, with the exception of the effect on the duration of the action potential, the relation with pH was markedly alinear, in that a rise in pH had much less effect than an equivalent fall.4. Statistical tests were devised to decide whether the observed changes were associated primarily with pH, P(CO(2) ) or bicarbonate. By far the strongest association was with external pH. Changes in P(CO(2) ), per se, had no significant effect.

Journal Article↗
PubMed1965

Alpha-amino nitrogen in cerebrospinal fluid and its alterations in meningitis, multiple sclerosis, and some other neurological disorders.

The concentration of alpha-amino nitrogen (a measure of total amino-acids) was estimated in 58 samples of cerebrospinal fluid in which other findings were normal. Values for lumbar and ventricular cerebrospinal fluid in adults, and lumbar cerebrospinal fluid in children, are reported. A relationship was found between the concentrations of alpha-amino nitrogen in lumbar cerebrospinal fluid and in plasma.Alpha-amino nitrogen was also estimated in 79 samples of fluid from patients with meningitis, cerebral tumour, multiple sclerosis, and other neurological disorders. High concentrations were found in meningitis, spinal block, and xanthochromic fluids. In cerebral tumours, the concentrations were mostly normal. Low concentrations were found in children, in many cases of multiple sclerosis, and in benign intracranial hypertension. In some cases, the changes cannot yet be explained.

Amino Acids↗