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Biomedical subjects

E M White

Publications and source records attributed to E M White.

At least 55 records · Page 3Linked to original sources
PubMed1985

Corn mitochondrial protein synthesis in response to heat shock.

Corn (Zea mays L., W23(N), OH43(N), and reciprocal single cross hybrid) seedling mitochondria respond to a 10 degrees C temperature shift (27-37 degrees C) by incorporating a greater amount of [(35)S]methionine into acid-insoluble material than mitochondria incubated at the original growing temperature (27 degrees C). This increase is in part manifested in the enhanced synthesis of a 52 kilodaltons protein. At both temperatures mitochondria of two inbreds and their reciprocal hybrids synthesize normal (N) cytoplasm proteins sensitive to chloramphenicol and insensitive to cyclohexamide treatment. The 52 kilodaltons protein is found in the supernatants of pelleted (15,000g, 5 min) mitochondria after heat shock. The role of this protein in the heat shock response is discussed in light of the implication of mitochondria as the primary cellular target to temperature stress.

Journal Article↗
PubMed1985

Surface coil MR imaging of abdominal viscera. Part I. Theory, technique, and initial results.

Prototype surface coil magnetic resonance (MR) images were obtained from phantoms and 42 subjects at 0.6 T to assess the feasibility of imaging relatively deep abdominal structures. Surface coil images demonstrated a two- to fourfold improvement in signal-to-noise ratio (SNR) when compared with whole-body coil images with the same resolution elements. This improvement in SNR allowed us to obtain images with thinner sections, higher in-plane resolution, or, alternatively, a decrease in image time. Compared with body images, surface coil images demonstrated greater anatomic detail and reduction in motion artifacts. Despite the limited field of view in very large patients, the use of surface coils improves the diagnostic capability of MR imaging of the abdomen.

Abdomen↗
PubMed1985

Surface coil MR imaging of abdominal viscera. Part II. The adrenal glands.

Magnetic resonance (MR) imaging of the adrenal glands with a prototype surface coil was compared with conventional body coil images in five healthy volunteers and 15 patients with adrenal disease. The spectrum of abnormalities included five nonfunctioning cortical adenomas, of which two were in hyperplastic glands, four adrenal metastases, three pheochromocytomas, a functioning adenoma, a myelolipoma, and a partially calcified, cystic adrenal mass. In both body and surface coil images, anatomic detail was superior on T1-weighted images compared with T2-weighted images obtained with identical imaging time because of decreased motion artifact and superior contrast. In the T1-weighted studies, high-resolution surface coil images showed a threefold improvement in signal-to-noise ratio (SNR) over body coil images, which was manifest by better intrinsic resolution of small adrenal lesions and clearer definition of the extrinsic relationships of large masses to nearby organs. In addition, inferior vena caval invasion by two right adrenal metastases was better demonstrated using the surface coil than body coil MR or computed tomography (CT). Limitations of surface coil imaging include restriction in the field of view to a single gland and additional time required for patient positioning. Since the sensitivity of surface coils diminishes with depth, gains in SNR were limited in large patients with deeper adrenal glands. Despite these limitations, dramatic improvements in SNR and anatomic resolution indicate that surface coil MR imaging will be competitive with CT for examining the adrenal glands.

Adrenal Gland Diseases↗
PubMed1985

Surface coil MR imaging of abdominal viscera. Part III. The pancreas.

Eight healthy volunteers and 11 patients with pancreatic abnormalities were studied using a conventional body coil and a prototype magnetic resonance (MR) surface coil. Final pathologic diagnoses included carcinoma of the head (six), body (one), and tail of the pancreas (two) and chronic pancreatitis (two). In surface coil images of the volunteers, the body and tail of the pancreas was visualized in all cases but one, and the pancreatic duct was seen in five of eight cases. In-plane spatial resolution of 0.9 X 0.9 mm and 5-mm section thickness was obtained. At the same time, pancreatic surface coil images had a twofold improvement in the signal-to-noise ratio (SNR) compared with body coil images. T1-weighted spin-echo images gave greater SNR, reduced motion artifacts, provided superior anatomic detail, and offered more diagnostic information than comparable T2-weighted images. Significant abnormalities detected only by surface coil imaging included a small tumor surrounded by reactive edema and periglandular tumor invasion. This study demonstrates that surface coil imaging of the pancreas not only is feasible but provides an improved method for examining the pancreas by MR.

Adult↗
PubMed1982

Reversal of lower esophageal sphincter hypotension and esophageal aperistalsis after treatment for hypothyroidism.

A 65-year-old woman suffered from both chronic gastroesophageal reflux, which was complicated by columnar metaplasia (Barrett's epithelium), and profound hypothyroidism. An esophageal motility tracing showed absence of peristalsis in the lower esophagus and the lower esophageal sphincter (LES) could not be identified. Thyroid replacement therapy, in conjunction with antacid and cimetidine treatment, was associated not only with improvement in the gastroesophageal reflux symptoms, but also with a return of esophageal peristalsis and LES pressure to normal. To support our clinical observations, we rendered four cats hypothyroid with 131I and documented a fall in LES pressure. We propose that abnormal smooth-muscle function of the esophagus may be another manifestation of the gastrointestinal motility disturbances which are associated with hypothyroidism.

Aged↗
PubMed1982

Use and modifications in group psychotherapy with chronic schizophrenic outpatients.

The authors have presented a framework for group psychotherapy with chronic schizophrenic outpatients which is based on belief that these patients can engage in moderately intensive insight-oriented therapy. The functional deficits and the interpersonal needs of these patients have been identified, and a strategy of intervention has been developed to ameliorate these deficits and facilitate gratification of these needs. Modifications in traditional group approaches are necessary for these groups to be a success. These include alterations in: 1) the group contract, 2) role and tasks of the therapists, and 3) use of special techniques. The authors believe that use of these techniques, informed by genuine interest in and empathy for these patients, will lead to a successful group experience for all.

Chronic Disease↗
PubMed1981

Use of ergonovine to identify esophageal spasm in patients with chest pain.

We administered intravenous ergonovine maleate to 14 patients with chest pain resembling angina pectoris and to four healthy volunteers. Five of the patients experienced their typical chest pain after ergonovine, and manometric signs of esophageal spasm also developed. The remaining nine patients and the four volunteers did not experience chest pain, but all subjects except one had some symptomatic response to ergonovine, including chest warmth or heaviness, headache, mild choking sensation, facial numbness, flushing, or nausea. Two of the nine patients and one of the four volunteers developed manometric signs of esophageal spasm after ergonovine but experienced no chest pain. Intravenous ergonovine may be useful to identify esophageal spasm in selected patients with chest pain who have normal coronary arteries or in whom coronary artery disease is insufficient to explain symptoms. However, we believe that the potential risks of ergonovine do not justify its routine use as a provocative agent for esophageal spasm.

Adult↗
PubMed1980

Blood parasites of some Jamaican birds.

The prevalence of avian hematozoa in 1791 birds of 80 species and 22 families from Jamaica was determined. Species of Haemoproteus were the most common hematozoan encountered. Species of Leucocytozoon were diagnosed only in three over-wintering North American migrants and the genus was absent in native Jamaican birds. The low prevalence of infection (7.4%) of blood parasites in Jamaican birds was closely similar to that seen in Neotropical birds and far below that noted for the Nearctic avifauna of the same families. Prevalence in adult and young birds was virtually identical; transmission occurred primarily during the period February-April.

Animals↗
PubMed1980

The type material of the International Reference Centre for Avian Haematozoa.

The type, paratype, and reference material of avian hematozoa in the reference collection of the International Reference Centre for Avian Haematozoa is listed. This material includes one species of Atoxoplasma, 41 species of Haemoproteus, one species of Hepatozoon, two species of Lankesterella, 15 species of Leucocytozoon, 31 species of Plamodium, one species of Spirogregarina, and three species of Trypanosoma.

Animals↗
PubMed1978

Blood parasites of some birds from Senegal.

A total of 809 birds from Senegal, including 43 species and 21 families, were examined for hematozoans; 93 birds (11.5%) harbored blood parasites, with only 7 (7.5%) harboring mixed infections. Species of Haemoproteus occurred in 81.7% of the infected birds while species of Plasmodium. Trypanosoma, microfilaria and Leucocytozoon were encountered less frequently. The majority of the sample was composed of species of ploceids and estrildidis and blood parasites were most prevalent in the colonial-nesting ploceids. Prevalence of blood parasites in Senegal was low in comparison to that seen in birds from other parts of Africa.

Animals↗
PubMed1978

Distribution of the hematozoa of Neotropical birds.

The literature pertaining to the prevalence of avian hematozoa in the Neotropics, together with unpublished records from the files of the International Reference Centre for Avian Haematozoa, has been examined with respect to the distribution of parasite genera by host family and region. The blood parasites of 35555 birds of 955 species (80 families) occurring in the Neotropics formed the basis for the comparisons. Only 3743 (10.5%) individuals harbored one or more species of hematozoa. Haemoproteus was the most commonly observed form exhibiting a 7.4% prevalence, followed by Plasmodium (1.9%), microfilaria (1.2%), Trypanosoma (0.6%), and Leucocytozoon (0.2%). Hematozoan prevalence varied markedly from region to region and among families. In comparison with a similar review of Nearctic avian hematozoan distribution, the Neotropics demonstrated a much lower prevalence and a near absence of Leucocytozoon.

Animals↗
PubMed1977

Additional observations on the blood parasites of Ugandan birds.

One thousand and seventy-six birds of 26 families and 127 species were examined for hemoprotozoa; 404 birds (37%) of 41 species representing 17 families harbored one or more blood parasites. Most parasites were species of Haemoproteus which represented 95% of all parasitic infections detected. Prevalence of blood parasites in birds collected from four areas over a period of six years was relatively stable.

Animals↗
PubMed1976

Predictive value of early developmental examination.

A developmental examination was carried out on 168 children at intervals over a 3-year period. The results suggest that developmental screening of this type is effective in picking out the "poor performers" who might well benefit from preschool education and extra health visitor supervision. On the other hand, the test given to children under the age of one year failed to pick out 2 children who were found to be moderately handicapped at the time of the 3-year examination. The study under-lined some of the problems of universal screening which require further research, and the need to assess the results of developmental screening clinic.

Age Factors↗