Biomedical subjects

E M Waldron

Publications and source records attributed to E M Waldron.

7 recordsLinked to original sources

PubMed2001

Suboptimality in human categorization and identification.

Categorization and identification decision processes were examined and compared in 4 separate experiments. In all tasks, the critical stimulus component was a line that varied across trials in length and orientation, and the optimal decision rules were always complex piecewise quadratic functions. Evidence was found that identification is mediated by separate explicit and implicit systems. In addition, a common type of suboptimality was found in both categorization and identification. In particular, observers apparently approximated the piecewise quadratic functions of the optimal decision rules with simpler piecewise linear functions. A computational model, which was motivated by a recent neuropsychological theory of category learning, successfully accounted for this suboptimal performance in both categorization and identification. The model assigns a key role to the striatum and assumes the observed suboptimality was largely due to massive convergence of visual cortical cells onto single striatal units.

California↗

PubMed2001

The effects of concurrent task interference on category learning: evidence for multiple category learning systems.

Participants learned simple and complex category structures under typical single-task conditions and when performing a simultaneous numerical Stroop task. In the simple categorization tasks, each set of contrasting categories was separated by a unidimensional explicit rule, whereas the complex tasks required integrating information from three stimulus dimensions and resulted in implicit rules that were difficult to verbalize. The concurrent Stroop task dramatically impaired learning of the simple explicit rules, but did not significantly delay learning of the complex implicit rules. These results support the hypothesis that category learning is mediated by multiple learning systems.

Adult↗

PubMed1999

On the nature of implicit categorization.

Current categorization models disagree about whether people make a priori assumptions about the structure of unfamiliar categories. Data from two experiments provided strong evidence that people do not make such assumptions. These results rule out prototype models and many decision bound models of categorization. We review previously published neuropsychological results that favor the assumption that category learning relies on a procedural-memory-based system, rather than on an instance-based system (as is assumed by exemplar models). On the basis of these results, a new category-learning model is proposed that makes no a priori assumptions about category structure and that relies on procedural learning and memory.

Classification↗

PubMed1998

A neuropsychological theory of multiple systems in category learning.

A neuropsychological theory is proposed that assumes category learning is a competition between separate verbal and implicit (i.e., procedural-learning-based) categorization systems. The theory assumes that the caudate nucleus is an important component of the implicit system and that the anterior cingulate and prefrontal cortices are critical to the verbal system. In addition to making predictions for normal human adults, the theory makes specific predictions for children, elderly people, and patients suffering from Parkinson's disease, Huntington's disease, major depression, amnesia, or lesions of the prefrontal cortex. Two separate formal descriptions of the theory are also provided. One describes trial-by-trial learning, and the other describes global dynamics. The theory is tested on published neuropsychological data and on category learning data with normal adults.

Adult↗

PubMed1995

Effects of exercise on dexterity.

As musicians occasionally report that their dextral facility is improved by recent exercise, it was hypothesized that manual dexterity would be influenced by a task requiring exertion. Before and after exertion on the Harvard Step Test, the experimental group's (n = 25) manual dexterity was tested on a grooved peg board. The control group's (n = 40) manual dexterity was measured before and after an inactive period. In both groups learning was significantly faster with the nondominant hand than with the dominant hand. Reasons why the hypothesis was not fully supported are discussed and suggestions for research noted.

Adult↗

PubMed1977

Fluorometric determination of histamine in tuna: development of method.

Tuna extracts are treated with an anion exchange resin to remove interfering materials, histamine is derivatized with o-phthaladehyde, and the fluorescence of the resulting compound is measured fluorometrically. Replicate analyses of acceptable and decomposed tuna packed in oil or water agreed within 1 mg at a level of 10 mg/100 g and within 12 mg at a level of 100 mg/100 g. Recoveries of histamine added to fish were greater than 90 and greater than 83% at levels of 10 and 100 mg/100 g, respectively. The new method is more rapid and specific and is simpler than previous methods because no liquid-liquid extractions or chromatographic separations of histamine are required. The sensitivity of the method allows quantitation of less than 10 mg histamine/100 g sample. The accuracy and precision of the fluorometric method are comparable to those of the official AOAC colorimetric method.

Animals↗

PubMedDate not supplied

Confirmation of identities of propylene and ethylene glycols in anchovies by tandem mass spectrometry.

A gas chromatographic/tandem mass spectrometric (GC/MS/MS) method has been developed for confirming the identity of propylene and ethylene glycols added to bait fish for preservation. Bait fish are occasionally illegally diverted to human food use. The bait fish were extracted with methanol, the extract was centrifuged and filtered, and the filtrate was concentrated 10-fold and then analyzed by GC/MS/MS. The glycols were separated chromatographically without derivatization or preliminary cleanup. Isobutane positive ion chemical ionization was used to generate the protonated molecular ion species of each glycol. Product-ion MS/MS experiments were performed to obtain spectra to confirm the identities of propylene and ethylene glycols. The identities of these 2 compounds in anchovy extracts were successfully confirmed by this approach.

Animals↗