Neurotoxic action of methyltetrahydrofolate in rat cerebellum unrelated to direct activation of kainate receptors.
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Biomedical subjects
Publications and source records attributed to E M Thomas.
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Using fluorescent histochemical methods it has been shown that the villi of the jejunum are innervated by noradrenergic fibres. Varicose fibres originating in the plexus associated with the arterioles of the submucosa run close to the central lacteal and extend to the villus tip. It is suggested that the nerves may be involved in the control of absorption although exactly which structure in the villi are innervated remains unclear.
Carbamylcholine, Pilocarpine and Atropine, but not Epinephrine, inhibited the motility of Herpetomonas samuelpessoai, when added to the suspension medium for 1 h. In addition, protozoan cells became spherical under the influence of atropine. This drug also induced the formation of the more differentiated opistomastigote form of the protozoan, in 60 per cent of growing cells, whereas these forms represented less than 5 per cent in untreated cultures. This may indicate that cholinergic receptors are present in this protozoan.
A consecutive series of 375 fractures of the radius and ulna in children of up to 15 years is described. At discharge from the fracture clinic, 65 failed to achieve a satisfactory result. After 4 years, however, only 9 children did not have normal function and only 1 was aware of any disability. The natural history of this injury is towards a complete functional recovery in the vast majority of cases.
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BACKGROUND: Pain is often poorly controlled in cancer patients. Chronic pain affects adult patients at all stages of cancer management. Optimal pain management may require attention to psychosocial variables and the inclusion of nonpharmacological techniques. METHODS: Three nonpharmacological strategies that are effective in reducing pain caused by cancer--patient psycho-education, supportive psychotherapy, and cognitive-behavioral interventions--are reviewed. Recommendations for physicians to facilitate a mental health referral are also discussed. RESULTS: Effective treatment of cancer pain begins with assessing the severity, characteristics, and impact of pain. Emotional distress (especially anxiety, depression, and beliefs about pain) has emerged as predictive of patient pain levels. Appropriate pain management may require a multidisciplinary approach. CONCLUSIONS: Patient psycho-education has empowered patients to actively participate in pain control strategies. Supportive psychotherapy can assist patients in managing the stressors associated with cancer, and cognitive-behavioral therapy helps patients to recognize and modify the factors that contribute to physical and emotional distress.