Biomedical subjects

E M Tararak

Publications and source records attributed to E M Tararak.

56 records · Page 4Linked to original sources

PubMedDate not supplied

[The regional morphological characteristics of the endothelium of the human thoracic aorta in perfusion fixation].

The ultramicroscopic organization and the endotheliocyte surface relief in ventral portions of the thoracic part of human aorta and in zones of division of blood flow were studied under conditions of early post mortem examinations and perfusion fixation of corpses of 14 humans dead from accidental causes. Zones of entrance into the intercostal aortas are compared with the straight portions of the aorta and are found to be characterized, as compared with the latters, by polymorphism of the endothelium, higher adhesiveness of its surface to blood elements, as well as by the presence of intravitally de-endothelialized portions localized on the ridge of the intimal valve.

Adolescent↗

PubMedDate not supplied

[The phenotypes of arterial smooth-muscle cells during ontogeny and in atherosclerotic plaques].

Smooth-muscle cell (SMC) myosin expression, SMC alpha-actin, h-caldesmon and calponin expression were studied in developing SMC of embryonic aorta as well as in adult human aorta and coronary arteries. It was found that ontogenesis is associated with SMC phenotypic modulations. In 8-23-week embryos SMC express SMC myosin and alpha-actin. In adult humans arterial SMC express all the markers studied. Normal subendothelium contains a heterogeneous SMC population. SMC heterogeneity is most marked in atherosclerotic plaques in the form of clusters of homogeneous cells different by expression of contractile system proteins. It is suggested that SMC heterogeneous population in atherosclerotic plaques may arise due to proliferation of phenotypically different precursors cells.

Adult↗