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Biomedical subjects

E M Jensen

Publications and source records attributed to E M Jensen.

At least 37 records · Page 2Linked to original sources
PubMed1982

The reflex dystrophy syndrome response to treatment with systemic corticosteroids.

Twenty-three patients with reflex dystrophy syndrome were randomly allocated to medication with oral prednisone, 10 mg thrice daily, or placebo, previous reports having indicated effect of systemic corticosteroids. The medication was continued until clinical remission, maximally 12 weeks. The diagnosis was based on fulfillment of at least four of seven criteria which included clinical, radiological and circulatory changes. All 13 patients in the prednisone-treated group showed more than 75% clinical improvement within the twelve-week period. Of the ten patients who received placebo, only two reported improvement. Prednisone appears to be superior to other treatment in reflex dystrophy syndrome, although the mode of action is not known.

Administration, Oral↗
PubMed1978

Steroid receptor analyses of nine human breast cancer cell lines.

Nine human breast cancer cell lines in permanent tissue culture and currently available to researchers have been assayed for their content of cytoplasmic estrogen receptors, progesterone receptors, androgen receptors, and glucocorticoid receptors, as well as for the presence of unfilled or hormone-filled nuclear estrogen receptors. Receptor distribution varied considerably among the nine lines and differed from the expected distribution predicted from solid tumors. We find that estrogen receptor, when present, is usually localized in the nucleus as unfilled nuclear estrogen receptor. Progesterone receptor is correlated with presence of unfilled nuclear estrogen receptor. Glucocorticoid receptors are ubiquitous; they were found in all cell lines tested. The distribution of androgen receptor and progesterone receptor differed, suggesting that these proteins are dissimilar.

Breast Neoplasms↗
PubMed1977

In vitro studies of chemical mutagens and carcinogens. I. Stability studies in cell culture medium.

A quantitative microbial assay was used to study the stability of known mutagenic and carcinogenic compounds in cell culture medium. Ten direct-acting carcinogens, when incubated in culture medium with 15% fetal bovine serum at pH 7.2-7.4 and 37 degrees C, became inactive at varying rates. Biologic half-lives of the test compounds ranged from 8 minutes to 67 hours. In contrast, six procarcinogens showed no significant inactivation after 3 weeks' incubation. The biologic half-lives of each compound were presented, and the significance of these findings as they relate to cell culture carcinogenesis and mutagenesis assays was discussed.

Carcinogens↗
PubMed1977

Reflex dystrophy. Resting blood flow and muscle temperatures as diagnostic criteria.

Fifty-one patients were examined following an injury of the upper extremity. Clinically, 25 patients were estimated as having reflex dystrophy, while the rest was categorized as either having a possible reflex dystrophy or acted as controls. Temperature and blood flow measurements were carried out on both extremities of the patients. The temperature of the brachioradial muscle and resting blood flow of the same segment of the forearm gave highly significant elevated values on the reflex dystrophic arms as compared with the healthy side, while the control patients revealed no such differences. Combination of these two parameters proved to give a specificity and sensitivity that high that they can be recommended as a diagnostic tool. A quantitative measurement and exact diagnosis make controlled trials on this group of patients easier in the future.

Arm Injuries↗
PubMed1972

Cytopathogenic test for feline leukemia virus infections.

A mixed culture cytopathogenic effect with the development of multinucleated giant cells in feline leukemia virus-infected cultures after cocultivation with XC cells is described. This cytopathogenic effect has been utilized as a convenient visual marker for the detection and assay of feline leukemia virus in feline and canine embryo fibroblasts as well as in a canine tumor cell line, M-132-1. Comparison of the cytopathogenic reaction in the three cell lines indicates that the reaction is more rapid and pronounced in M-132-1 cells than in the embryo fibroblast cultures.

Alpharetrovirus↗