Biomedical subjects

E M Higgins

Publications and source records attributed to E M Higgins.

76 records · Page 5Linked to original sources

PubMedDate not supplied

Isoforms of transferrin in psoriasis patients abusing alcohol.

The different isoforms of transferrin have been quantified by isoelectric focusing in the sera of psoriasis patients with and without a history of abusing alcohol. In both male and female psoriasis subjects abusing alcohol, there were significant increases in the 2-sialylated forms by comparison to the control subjects. Psoriasis patients who had no evidence of alcohol abuse had similar profile for the isoforms of transferrin to that of the controls. Other groups of patients with alcohol-induced tissue damage, i.e. liver, brain or muscle, used as positive controls, similarly showed significant increases in the 2-sialylated forms, by comparison to controls. These results substantiate the current use of carbohydrate-deficient transferrin as a sensitive marker of alcohol abuse, particularly in subjects not drinking in excess of 60 g of ethanol/day but showing alcohol-related psoriasis.

Adult↗

PubMedDate not supplied

Cutaneous leishmaniasis: three children with Leishmania major successfully treated with itraconazole.

We report the rare instance of four family members with numerous cutaneous lesions of Leishmania major contracted while on holiday in Algeria. Treatment was successful with oral itraconazole for the children and intralesional sodium stibogluconate for the mother. Cutaneous leishmaniasis should be considered in those with apparently sterile plaques returning from endemic areas. These results suggest that itraconazole, which is ideally suited for use in children, is an effective monotherapy for L. major.

Administration, Oral↗

PubMedDate not supplied

Cutaneous manifestations of malignant disease.

This review discusses the more common cutaneous disorders associated with internal malignancy. Some rare but specific entities are included, and some recently recognized associations are highlighted. Particular emphasis is given to the key physical signs, which can alert the physician to the possibility of underlying neoplastic disease.

Acanthosis Nigricans↗

PubMedDate not supplied

Cutaneous manifestations of non-HIV immunosuppression.

Advances in organ transplantation and chemotherapeutic techniques have led to an increased interest in both the early and long-term complications of immunosuppression. This article reviews many of the cutaneous complications and highlights the importance of regular skin surveillance in these patients.

Bacterial Infections↗