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Biomedical subjects

E M HOWARD

Publications and source records attributed to E M HOWARD.

At least 19 recordsLinked to original sources
PubMed1959

The effect of adrenal steroids and corticotrophin on the growth of a sarcoma of human origin in small laboratory animals.

9alphaFluorohydrocortisone, prednisolone, and hydrocortisone promoted the growth of the human tumour (H.S.l) in weanling rats, but deoxycortone acetate was ineffective even when injected in very high dosage; Cortrophin ZN, a long-acting corticotrophin preparation, was just as effective as cortisone. This effect of corticotrophin on tumour growth was mediated by the adrenal cortex, and was related to the enhanced secretion of adrenocorticoids; some correlation existed between tumour size and adrenal hypertrophy in the corticotrophin-treated rats. The action of adrenal steroids and of corticotrophin in promoting the growth of the tumour is discussed.

Adrenal Cortex↗
PubMed1958

The influence of cortisone and hydrocortisone acetates on the course of Mycobacterium lepraemurium infection in rats.

Prolonged administration of cortisone acetate or hydrocortisone acetate produces a decrease in the rate of growth of treated rats. In this respect the effect of the latter steroid is the more pronounced. Lepromata in the steroid treated animals are significantly smaller than those in the control rats. This difference is more pronounced with the cortisone acetate treatment. However, whilst there is no appreciable difference in the distribution of organisms in the lepromata, the spread of infection is not increased by the steroid treatment, as the number of animals showing acid fast organisms in the spleen is no greater in the treated groups than in the controls.

Animals↗