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Biomedical subjects

E M Farrell

Publications and source records attributed to E M Farrell.

32 records · Page 2Linked to original sources

Primary liver amyloidosis producing obstructive jaundice.

Liver amyloidosis is very rare but is relatively common within the group of amyloid diseases. Jaundice seldom accompanies this condition. Since the results of liver tests are often abnormal, liver amyloidosis cannot be diagnosed by symptoms alone. Diagnosis is provided only by liver or rectal biopsy. We have described an elderly woman with vague digestive symptoms for several months and jaundice for two weeks before hospitalization, and in whom exploratory laparotomy showed amyloidosis causing obstructive jaundice.

Aged↗

Simultaneous bilateral aspiration of foreign bodies.

Aspiration of foreign bodies into the bronchial lumen continues to be a potential hazard especially in children. Bronchiectasis, lung abscesses, emphysema, or pleuropulmonary fistula may develop if untreated. The treatment of choice is extraction by bronchoscopy under general anesthesia. Our patient simultaneously aspirated two squirrel vertebrae, neither of which produced obstruction. The patient's symptoms were due mainly to the partial obstruction secondary to the formation of granulation tissue. One aspirated vertebra was extracted during the diagnostic fiberoptic bronchoscopy, but a rigid Jackson bronchoscope was necessary to remove the other foreign body. The patient has since been asymptomatic.

Animals↗

Severe tracheal stenosis after brief endotracheal intubation.

The most serious complication of endotracheal intubation is ischemic mucosal necrosis and subsequent stenosis caused by excessive cuff pressure. An instance of tracheal stenosis occurring after only 72 hours of intubation is presented. Resection of the stenotic segment with primary end-to-end anastomosis was curative. There has been no recurrence after six months.

Adult↗

Vaginal adenocarcinoma in a gravida with prenatal DES exposure.

The article presents a case of a young pregnant woman with vaginal carcinoma who had been exposed to diethylstilbestrol (DES) in utero. Surgical excision of the lesion was attempted but failed. Interstitial irradiation was then applied and proved successful. The patient's infant, as well as two subsequent children, were delivered by cesarean section after normal pregnancies. There was no evidence of metastatic disease or recurrence in 11 1/2 years following the initial diagnosis. Since 1965, a rising incidence of vaginal adenocarcinoma in women who were exposed to (DES) in utero has been reported. These women should be examined regularly after menarche for prompt evaluation and treatment of precancerous lesions such as adenosis, cervical erosion or transverse ridges. Since most of these patients are young, a conservative treatment is recommended. Extensive surgery and pelvic irradiation is indicated, however, in the cases of widespread disease.

Adenocarcinoma↗

Pulmonary resections with staplers.

The use of mechanical stapling devices for closure of the bronchus, pulmonary arteries and veins and lung parenchyma in twenty-six consecutive patients undergoing various types of pulmonary resection is presented. There have been no complications.

Adult↗

Functioning insulinoma with a twenty-year history.

A case of functioning beta islet cell tumor (insulinoma) producing incapacitating hypoglycemia for 20 years before being diagnosed by means of pancreatic angiography is presented. Laparotomy with local tumor excision was curative.

Adenoma, Islet Cell↗

Tracheostomy tube insertion in the pretracheal fascia.

A case of massive dissecting emphysema secondary to attempted emergency tracheostomy is reported. Malpositioning of the tube in the pretracheal fascia and positive pressure ventilation were the cause of the dissecting emphysema. This problem was recognized with subsequent removal of the tracheostomy tube, but unfortunately the skin was sutured which prevented air from escaping. The diagnosis was made by physical examination and chest roentgenogram. It was successfully treated by reopening of the wound and evacuation of clots. Careful technique performed under optimal conditions is of paramount importance in avoiding this complication.

Adult↗

Postoperative acalculous cholecystitis.

Two cases of acute acalculous cholecystitis occurring after major surgical procedures unrelated to the biliary tract are described. Symptoms are usually masked by postsurgical pain. Gangrene and perforation usually occur; this explains why the mortality rate is high. Awareness of this complication is essential; it leads to the early performance of cholecystostomy or cholecystostomy, lifesaving procedures.

Adult↗