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Biomedical subjects

E M Difonzo

Publications and source records attributed to E M Difonzo.

At least 19 recordsLinked to original sources

[Universal dermatophytosis (tinea incognito) caused by Trichophyton rubrum].

An 84-year-old male presented with a dermatophyte infection that had spread over nearly the entire body surface. The first signs had developed 48 years before. After treatment with galenic and corticosteroid preparations for diagnoses of "eczema" and "psoriasis", the lesions gradually extended over the body and to the nails. The cutaneous symptoms had worsened in recent year after the patient had started systemic cortisone treatment for bronchial asthma. He also developed diabetes mellitus, papulonodular lesions on the face and limbs, thinning of his hair and eyebrows and hyperkeratosis of the soles and palms.

Aged

Epidemiology of the dermatophytoses in the Florence area of Italy: 1985-1990. Trichophyton mentagrophytes, Epidermophyton floccosum and Microsporum gypseum infections.

Between 1985 and 1990 we observed 2085 cases of dermatophytoses in the Florence area of Italy. Trichophyton rubrum and Microsporum canis were the major etiological agents. 126 cases of dermatophytoses observed during this period were caused by Trichophyton mentagrophytes. Most of the patients came from rural areas or they kept pets. Epidermophyton floccosum ranked fourth in frequency (95 cases). The patients were adults and mainly males, most of whom engaged in sports or lived in group environments. Microsporum gypseum was isolated in 31 cases. Infections occurred directly from contact with soil or domestic animals. We report the principal clinical data concerning these last three dermatophyte infections.

Adult

[Yellow, but healthy. Report of 4 cases of diet-induced carotenosis].

Four women who had been following a "healthy" diet based on carrots and citrus fruits for some time presented with yellow-tinged skin. All four patients had high carotene levels in the blood, and three were also found to have slightly increased vitamin A levels. The other laboratory test results were normal. They were prescribed diets that did not contain carotene-rich foods, and both skin colour and laboratory tests returned to normal.

Adult

[Benign symmetric lipomatosis].

Benign symmetric lipomatosis is a rare disease that predominantly affects males. A close correlation with alcohol and nicotine abuse, metabolic disturbances and malignant tumours of the upper airways has been observed. We report the case of a 61-year-old female patient whose first clinical lesions had appeared more than 30 years earlier. The huge enlargement of fatty tissue had also involved her face. Case history, laboratory findings and radiological and ultrasound examinations allowed us to exclude metabolic disturbances and associated diseases.

Adipose Tissue

[Tinea corporis caused by Microsporum gypseum].

Human infections due to microsporum gypseum are rare. We report on a female patient who had tinea corporis caused by M. gypseum after a cutaneous wound. The numerous lesions located on the borders of the wound had an eczematous appearance.

Adult

[Tungiasis: a rare consequence of the fascination by the exotic?].

The paper reports three cases of tungiasis observed within the space of 6 months in patients who had spent part of their holidays in the Ivory Coast, Brazil and Senegal respectively. Spontaneous recovery probably makes the observation of this disease more rare.

Adolescent

Itraconazole in dermatophyte infections: clinical experience in Italy.

Approximately 200 patients with clinically and mycologically diagnosed dermatophytoses were treated with itraconazole. The drug was administered at a dose of 100 mg with the main meal. Therapy duration was as follows: tinea corporis and tinea cruris, 14 days; tinea pedis and tinea manuum, 28 days; tinea unguium of hands, three months, and feet, six months; tinea capitis, 30 days. Clinical and mycological control tests (eg, direct microscopy and culture) were performed prior to treatment, at the end of treatment and two and four weeks after the end of treatment. Blood chemistry parameters were measured before and at the end of treatment. The results of the research presented here mirror exactly those of international research and therefore confirm that itraconazole is both active and well tolerated in the treatment of dermatophytoses.

Antifungal Agents

Hair casts.

A case of hair casts in an 8-year-old girl is described. The disorder is rare, the first description dating back to 1897 with a total of only 31 cases reported in the literature since then. The results of research conducted using the optic and electron microscopes (transmission and scanning) are recorded. These studies show that the typical lesion consists of two concentric layers of keratinized cells of differing structure: one resembling the inner layer of Huxley's sheath and the outer layer resembling Henle's layer.

Child

Tinea capitis in the adult: two case studies.

The authors describe two cases of tinea capitis in adults, one due to Microsporum canis and the other to Trichophyton rubrum. The atypical clinical presentation of the dermatophytosis in these two cases is stressed. It is hypothesized that in both cases the disease spread from primary lesion on the face.

Aged