Employing a human fetal liver library in lambda Charon 4A phage vector, we have isolated and characterized three clones of human DNA containing genes for tRNAs. One clone contains at least three tRNA genes (tRNALys, tRNAGln and tRNALeu) within 2 kb of each other. The other two clones contain two different single genes for tRNAAsn. One of these latter two DNAs also contains a gene for U1 small nuclear RNA.

Base Sequence↗

PubMedDate not supplied

Human nickel exposure in an area polluted by nickel refining: the Sør-Varanger study.

Sør-Varanger municipality in northern Norway is located close to two Russian nickel refineries that cause nickel and sulfur dioxide pollution. To investigate individual nickel exposure and possible health effects from the pollution, the authors invited all adults who were 18-69 y of age to a health survey in 1994. Urine samples were collected from 3671 participants (participation rate = 59.4%), and nickel concentrations were determined for 902 of them. Mean and median nickel concentrations were 0.9 microg/l and 0.6 microg/l, respectively. Individuals who lived in the rural areas closest to the refineries had lower nickel concentrations than individuals who lived in the more urban areas. Independent risk factors for nickel concentrations in urine were (a) being an urban dweller and (b) living close to areas with high-density traffic. The authors concluded that nickel exposure attributable to air pollution from Russian refineries was of minor importance for people who lived in Sør-Varanger.

Adolescent↗

PubMedDate not supplied

EC4 European syllabus for post-graduate training in clinical chemistry. Version 2--1999. European Communities Confederation of Clinical Chemistry, EC4 Register Commission.

Explore the source record for details and available documents.

Chemistry, Clinical↗

PubMedDate not supplied

Prader-Willi syndrome and central nervous system calcifications: chance or fundamentally related findings?

The central nervous system of a 16 8/12-year-old boy with Prader-Willi syndrome is described. Extensive calcifications of the central nervous system were observed at autopsy as grittiness of the brain slices and verified by X-ray and microscopy. The encrustations were particularly localized in the leptomeninges, the first and second layer of the cerebral and cerebellar cortex and along the ventricular system. We suggest that the alterations are nonspecific and perhaps secondary to a fundamental metabolic disorder in the central nervous system.

Adolescent↗