Occlusion of the iliac artery in an 18-year-old man.
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Biomedical subjects
Publications and source records attributed to E Luckmann.
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The functional dissociation (FD) of conduction within the AV-node is characterized by sudden prolongations and/or shortenings of the AH-time during stimulation. Examples for FD are presented during regular atrial stimulation and atrial extrastimulus technique. The appearance of FD is no proof for functional impairment of the AV-node. The blockade of the parasympathetic nervous system abolishes FD and leads to the well known continuous and regular adaptation of the AH-time with the various kinds of stimulation examined. It is recommended to replace the term "pathways" by the more comprehensive concept of functional dissociation with the AV-node.
In 18 patients the influence of aprindine on sinus node function has been evaluated. The criteria were heart rate in spontaneous rhythm, sinus node recovery time (SRT), and the warm-up period after atrial stimulation with frequencies between 90 and 140/min. After aprindine the spontaneous rate increased significantly, whereas SRT and the warm-up period were not affected significantly. The patients with sinu-atrial disease showed a shortening of the spontaneous cycle-length and a decrease in SRT after aprindine. The results are discussed regarding the electrophysiological characteristics of the sinus node (slow current, automaticity) and their changes produced by stimulation and aprindine.
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The functional behaviour of the healthy and sick human AV-node under various clinical-experimental conditions is described with special reference to (1) AV-nodal conduction, (2) AV-nodel refractoriness, (3) influence of autonomic tone and (4) role of the AV-node in the initiation of rhythm disturbances.
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