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Biomedical subjects

E Lodemann

Publications and source records attributed to E Lodemann.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Event-related brain potentials and intellectual impairment--a study in patients with brain tumor and craniocerebral trauma].

Event-related potential recording (component N1, P2, N2, and P3) and neuropsychological assessment of cognitive impairment were carried out on 15 patients with brain tumour, 15 patients with severe head injury and 24 controls. The tumour and trauma patients had significantly lower psychological test scores, smaller N1 amplitudes and longer N2 and P3 latencies than normals. For the tumour and trauma patients significant correlations were found between N2 and P3 latency and the Mini-Mental State test and memory tests. For individual patients abnormally increased N2 and P3 latency was found to occur in association with abnormally reduced neuropsychological test scores. N2 and P3 latency proved the only electrophysiological variables examined which provided a measure of cerebral functioning correlating with the psychometric variables. N2 and P3 latency may be regarded as a useful diagnostic test for cognitive impairment especially in patients with motor handicaps, to whom neuropsychological tests cannot be administered.

Adult↗
PubMed1985

Serum interferon level and (2'-5')oligoadenylate synthetase activity in lymphocytes during clinical interferon application.

Determinations of (2'-5')oligoadenylate synthetase (OAS) in extracts of peripheral mononuclear cells were used to monitor clinical treatment by human leukocyte-derived alpha-interferon (IFN-alpha). The maximum activity of this enzyme was detected about 6 h after the maximum IFN activity in the patient's serum, its half-life being severalfold longer than that of circulating IFN. Thus, even some days after its clearance, IFN can be detected by means of this enzyme. Sixfold increases of the IFN dose were not able to further increase OAS activity induced by doses of about 5 X 10(4) units/kg body weight in adult persons. Intravenous administration of IFN seems not to be superior to its i.m. injection.

2',5'-Oligoadenylate Synthetase↗
PubMed1984

[Interferons--research, effects and importance].

Interferons are a family of proteins synthesized by the cells of higher organisms as a first reaction to viral infections, preceding the immune response. They are also involved in the regulation of the immune system and therefore included among the lymphokines. Since they had been shown to have antitumor activity in vitro and in experimental animals, they were suggested to be powerful drugs in cancer therapy.

Animals↗
PubMed1984

(2'-5')oligo(A) synthetase as a monitor of interferon action in juvenile laryngeal papillomatosis.

Four children with juvenile laryngeal papillomatosis were treated with human leukocyte interferon (IFN-alpha) by intravenous infusions. In three cases the clinical course of the disease was effected favorably. Serum IFN titers and (2'-5')oligo(A) synthetase (OAS) levels in lymphocytes of the patients were measured once a week during therapy. Levels of serum IFN determined 15 min after the end of 1 h infusions corresponded to only 15%-40% of the amount infused. Comparable OAS activities in the four children were measured before infusion, i.e., one, two, or three days, respectively, after the preceding infusion, though mean IFN titers of the patients differed from each other (200-400 and 400-600 u/ml). This suggests a saturation of the lymphocytes' antiviral system by these IFN levels. A discontinuation for two weeks in the early phase of IFN treatment, accompanied by a decrease of the OAS activity in the lymphocytes to the basal level, resulted in a deterioration of the patient's condition. A change in treatment schedule causing a decrease of OAS activity to a lower, though still elevated level, for six weeks until the present did not influence the course of therapy. Therefore, we suppose that the maintenance of elevated levels of OAS activity in lymphocytes for some months may be a necessary, even though not always a sufficient, criterion for a successful therapy schedule in IFN treatment of juvenile laryngeal papillomatosis. In addition, our results suggest OAS activity to be suitable in monitoring effects of an IFN therapy.

2',5'-Oligoadenylate Synthetase↗
PubMed1980

Quantitative determination of small amounts of L-penicillamine in D-penicillamine after desulfurization with Raney nickel.

Commercially available D-penicillamine is desulfurized with Raney nickel at room temperature in aqueous solution. L-Valine derived from contaminating L-penicillamine is determined colorimetrically by the amino acid oxidase/peroxidase reaction, using 2,2'-azino-di-[3-ethyl-benz-thiazoline-sulfonate(6)] (ABTS). The procedure assures the quantitation of L-penicillamine contaminating D-penicillamine down to the level of 0.1%.

Drug Contamination↗
PubMed1979

[D-Penacillamine. From constituent of penicillins to significant drug].

D-Penicillamine is used against a variety of diseases. For many years it has been successful in treating Wilson's disease, cystinuria and heavy-metal poisonings. It also proved to be effective against rheumatoid arthritis, scleroderma, chronic active hepatitis, pulmonary fibrosis and multiple sclerosis. However, the use of D-penicillamine is still limited owing to the frequent occurrence of considerable, though generally reversible, side effects. This article deals with the history of D-penicillamine as well as the methods of its synthesis, its pharmacokinetics, effects and side effects. In addition, the significance of the stereo isomeric L-penicillamine is discussed.

Arthritis, Rheumatoid↗
PubMed1977

Aminoacylation of rat liver transfer RNA with L-penicillamine. On the specificity of the aminoacylation reaction.

L-]14C]Penicillamine is bound to RNA from rat liver in an in vitro reaction catalyzed by rat liver aminoacyl-tRNA synthetases. Addition of certain naturally occuring amino acids results in a significant decrease of L-penicillamine binding. The most potent inhibitor of this binding is L-valine, followed by L-isoleucine and L-threonine. Amino acids without structural relationship to L-penicillamine in the non-functional part of the molecule, such as L-phenylalanine, are ineffective. Studies on the competition of L-penicillamine and L-isoleucine, respectively, with L-valine demonstrate the high specificity of the aminoacylation reaction. They show that the change of L-penicillamine binding to tRNA Val is considerably lower than that of L-valine.

Amino Acids↗