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Biomedical subjects

E Lindberg

Publications and source records attributed to E Lindberg.

At least 73 records · Page 4Linked to original sources
PubMed1989

Urinary excretion of chromium in chromeplaters after discontinued exposure.

In a previous study [Lindberg and Vesterberg, 1983a], excretion of chromium in urine (U-Cr) in chromeplaters was proposed for biological monitoring of ongoing exposure. Published reports were found about the decline of U-Cr after discontinued exposure in welders working in chromium-alloyed stainless steel, but not in chromeplaters. In this study, half-times (t1/2) were calculated for ten chromeplaters over a weekend, and for 23 chromeplaters over 31 days vacation. The results suggest that the excretion of chromium can be approximated to a two-compartment model. Estimated from the median values, an initial rapid phase with an assumed t1/2 of 2-3 days is followed by a phase with a t1/2 of approximately a month. Differences between the decline of U-Cr in chromeplaters and welders are discussed.

Chromates↗
PubMed1988

Smoking and inflammatory bowel disease. A case control study.

A population case controlled study of smoking habits at the time of diagnosis was done in 260 patients with ulcerative colitis and 144 with Crohn's disease. Smokers had a decreased risk of acquiring ulcerative colitis in comparison with never smokers (relative risk 0.7) which appeared to be dose dependent. In former smokers a rebound effect was seen, especially in former heavy smokers, where the risk was sharply increased (relative risk 4.4). No sex difference was recorded. Smoking doubled the risk of acquiring Crohn's disease without any dose dependent pattern. In former smokers a non-significantly increased risk was observed. This might be caused by a carry over effect after stopping smoking, however, which possibly is reduced by time. No sex difference was seen.

Adult↗
PubMed1988

Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.

By running the Swedish twin registry containing about 25,000 pairs of twins of the same sex together with the central national diagnosis register of hospital inpatients, 80 twin pairs suffering from inflammatory bowel disease were found. In the ulcerative colitis group one of 16 monozygotic pairs was concordant for the disease, but all the other 20 pairs (dizygotic or unknown zygosity) were discordant. In the Crohn's disease group eight of 18 monozygotic pairs and one of 26 dizygotic pairs were concordant. The proband concordance rate among monozygotic twins was 6.3% for ulcerative colitis and 58.3% for Crohn's disease. The calculated heritability of liability based on monozygotic pairs was 0.53 and 1.0 respectively. Thus heredity as an aetiological factor is stronger in Crohn's disease than in ulcerative colitis. Monozygotic twins with Crohn's disease were more likely to be smokers than monozygotic twins with ulcerative colitis. Smoking did not explain the discordance of twin pairs with either ulcerative colitis, or Crohn's disease. The combination of identical heredity and similar smoking habit is not sufficient to cause disease.

Adolescent↗
PubMed1988

Experiences in the psychotherapy of rheumatoid arthritis.

According to the relevant literature, psychological factors may play an important role in the onset and clinical course of rheumatoid arthritis. This is the first study reported in which the treatment of rheumatoid arthritis is based on such factors. Twenty-seven arthritics were treated psychotherapeutically and a close connection was seen between the course of the psychotherapy and the development of the somatic disease.

Arthritis, Rheumatoid↗
PubMed1985

beta 2-Microglobulinuria among workers previously exposed to cadmium: follow-up and dose-response analyses.

Sixty workers (58 males, 2 females) who had previously been exposed to cadmium in connection with the use of cadmium-containing solders were examined. Exposure times ranged from 4 to 24 years. For each worker a cumulative cadmium dose estimate was calculated. This ranged from 0.35 to 9.9 mg/m3 X year. The prevalence of slight (U-beta 2 greater than 0.034 mg/mmole creatinine) and more pronounced (U-beta 2 greater than 0.1 mg/mmole creatinine) beta 2-microglobulinuria in the whole group was 40% and 23%, respectively. The prevalence of beta 2-microglobulinuria was strongly related to the cumulative dose estimate and to urinary cadmium level. Among workers with a cumulative dose estimate below 1 mg/m3 X yr there were only a few cases with slight tubular proteinuria, whereas for workers who had a cumulative dose estimate exceeding 3 mg/m3 X yr the prevalence of slight and pronounced beta 2-microglobulinuria was 77% and 54%, respectively. There was no significant relationship between the concentration of beta 2-microglobulin in serum and urine. This indicates that the beta 2-microglobulinuria is due to tubular damage and is not secondary to an increased endogenous production. Repeated examinations of 19 workers between 1976 and 1983 revealed that in almost all cases the beta 2-microglobulinuria was irreversible.

Adult↗
PubMed1985

Assessment of renal function in workers previously exposed to cadmium.

Cadmium induced renal effects were examined in 60 workers (58 men, 2 women) previously exposed to cadmium. Tubular damage in the form of beta 2-microglobulinuria was found in 40%, and urinary albumin and orosomucoid increased significantly with increasing urinary cadmium and increasing relative clearance of beta 2-microglobulin. It is suggested that increased albumin excretion is secondary to the tubular damage. In no case was typical glomerular proteinuria found that could be related to cadmium. Histories of renal stones were more common among the workers with high urinary cadmium concentrations. The glomerular filtration rate was measured in 17 of the workers who had pronounced tubular dysfunction. The average glomerular filtration rate for these men was less than the age adjusted predicted value (mean = 84%). Furthermore, there was a significant (p less than 0.05) correlation (r = -0.47) between tubular reabsorption loss and a decreased glomerular filtration rate.

Adult↗
PubMed1983

Urinary excretion of proteins in chromeplaters, exchromeplaters and referents.

Urinary excretion of proteins in chromeplaters, exchromeplaters and referents. Scand j work environ health 9 (1983) 505-510. beta 2-microglobulin was measured in the urine of 24 presently exposed chromeplaters, 27 previously exposed chromeplaters, and 37 referents. The concentration of beta 2-microglobulin and the number of "elevated" values (greater than 0.30 mg/l) was higher in the presently exposed group than in the referents. Within the presently exposed group there was a dose-effect relation between the concentration of hexavalent chromium in air and the number of elevated values of urinary beta 2-microglobulin. However, no difference between the previously exposed chromeplaters and the referents could be demonstrated regarding urinary beta 2-microglobulin. There were no indications that the exposure could raise the excretion of albumin in urine. The results seem to indicate an acute effect on the kidney tubules, which is reversible even in workers who have had a relatively high exposure to chromic acid.

Adolescent↗
PubMed1983

Monitoring exposure to chromic acid in chromeplating by measuring chromium in urine.

With personal air samplers, exposure to hexavalent chromium was measured in a group of eight chromeplaters during a period of 5 d; urine samples were collected at all times of urination for 7 d. The concentration of chromium in the urine increased from Monday morning to Tuesday afternoon and then remained constant within the group as a whole throughout the rest of the work week. In a large group of 90 chromeplaters exposure was measured for 1 d, and urine samples were collected before and after the workshift on Monday and Thursday of the same week. There was a correlation between the exposure and the concentration of chromium in postshift urine samples on Thursday (correlation coefficient 0.71). Concentrations of chromium in urine of less than or equal to 100 nmol/l indicate time-weighted average values of exposure of about or below 2 micrograms/m3. Below this exposure no severe damage to the nasal septum and no influence on lung function have been found. After the initial measuring of the airborne hexavalent chromium and the concentrations of chromium in the urine of exposed workers, urine analyses are recommended for follow-up controls.

Adolescent↗
PubMed1982

Psychotherapeutic examination of patients with suspected chronic solvent intoxication. An overview.

A group of 13 patients, most of them house or industrial painters with strong evidence of chronic solvent intoxication were given psychotherapy, with a view to ascertaining whether psychological factors may have contributed to the signs and symptoms that had persisted after the acute manifestations had either diminished or ceased altogether. All the patients were found to have experienced severe psychic traumata during their first year of life-the preverbal period. This had resulted in defective development of language, which was reflected in a lack of words for expressing emotions; instead these were expressed nonverbally as somatic symptoms. The results of the study indicate unequivocally that in none of the 13 patients were the symptoms due to the toxic effect of solvents, all of them having a psychological rather than a somatic causation. After an analysis of the symptoms by means of an established psychotherapeutic method they diminished in severity and a number of the patients recovered completely.

Adult↗