CT demonstration of giant cell tumor complicating Paget disease.
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Biomedical subjects
Publications and source records attributed to E Lewis.
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Five patients with known primary malignancy demonstrated fatty infiltration of the liver on routine computed tomography (CT) examination. Within the diffuse fatty infiltration were focal areas of relatively increased beam attenuation in four cases. These areas of increased beam attenuation are nonspecific as to etiology. Their differential diagnosis is discussed. Since the true extent of the neoplastic process may be underestimated by conventional CT and celiac angiography, superselective angiography, computed angiotomography, or biopsy is required to accurately assess the etiology and the extent of the disease.
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The various radiologic methods used in the detection of hepatic lesions in the oncologic patient are discussed. The advantages and disadvantages of each imaging technique as well as a new diagnostic approach are also discussed. With the rapid technological advances made in cross-sectional imaging, the authors believe that ultrasound and, whenever possible, computed tomography, should be used as the screening method.
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Plant sterols and triterpenes exhibit a wide range of pharmacological activities. As part of our ongoing studies of the medicinal aspects of Maritime flora, particularly the herbal remedies of the Micmac and Malecite Indians, we determined the nature of the sterols and triterpenes of Tanacetum vulgare L. (Compositae)-a widely used herbal remedy usually referred to as tansy. By using thin layer and gas chromatographics, nuclear magnetic resonance (NMR) spectroscopy and combined gas chromatography-mass spectrometry, we were able to identify beta-sitosterol as the major sterol and alpha-amyrin as the major triterpene of tansy. We also identified the sterols stigmasterol, campesterol and cholesterol, and the triterpenes beta-amyrin and taraxasterol. A fourth triterpene was tentatively identified as pseudo-taraxasterol. The successful therapeutic application of this herb may be due partly to the presence of one or more of these compounds. The sterols and triterpenes of tansy have not been previously reported; neither, to our knowledge, have the NMR spectra of the amyrins and the NMR and mass spectra of taraxasterol.
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Computed tomography (CT) scans of the chest and routine postero-anterior and lateral chest films were compared in 32 patients with pathologically proven oat cell carcinoma of the lung. Nineteen of the 32 patients were examined prior to any form of therapy. Overall, CT gave more information about the extent of disease. The significance of this information may be of little value because the routine chest films also demonstrated mediastinal involvement, although to a lesser degree. Computed tomography of the chest should not be the initial diagnostic staging procedure in oat cell carcinoma, but used selectively. It can be quite useful in patients who have a partially opacified lung, possibly for the evaluation of mediastinum after therapy, and for the evaluation of possible abdominal metastases.
The demonstration by computed tomography (CT) of enlarged nodes and/or masses in lymphoma patients has been interpreted as indicating that active disease is present. Four cases are presented in which either biopsy or laparotomy of a CT-detected mass after therapy revealed fibrous tissue with no evidence of viable neoplasm. These four cases demonstrate the possible pitfall of diagnosing viable lymphoma in masses detected by CT after therapy.
The use of an experimental liposoluble contrast agent-Ethiodized Oil Emulsion 13 (EOE 13)--is described in hepatic computed tomography (CT) of 23 oncologic patients. Without exception, all the hepatic metastases were better delineated in the EOE 13 enhanced scans. The postcontrast scans also detected an increased number of lesions but not all were malignant. There is no specificity to the increased lesion detection. Various splenic abnormalities were detected. Very few minor side effects and no major side effects were caused by the contrast media. We feel that with time, hepatic specific agents such as EOE 13 will become the contrast media of choice in hepatic CT examinations. Also, CT with hepatic specific agents may become the preoperative examination of choice in candidates for partial hepatectomy.
The diagnosis of a thymic cyst of the neck must be considered particularly in a male child with a mass that is lateral, soft, asymptomatic, and closely related to the carotid sheath. Although rare in the literature, this entity is probably more common than usually appreciated. A patient with this condition has been reported along with a review of previous publications on this subject.