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Biomedical subjects

E Levine

Publications and source records attributed to E Levine.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

Abdominal visceral calcification in secondary amyloidosis: CT findings.

Amyloid fibrils have an affinity for calcium, and radiographically detectable calcified amyloid deposits may occur in both primary and secondary amyloidosis. However, abdominal visceral calcification is rare. A patient with secondary amyloidosis due to juvenile rheumatoid arthritis is described who developed extensive liver, adrenal, and renal calcification shown by computed tomography. Adrenal calcification in amyloidosis has not been previously described.

Adrenal Gland Diseases↗
PubMedDate not supplied

Disruption of classical conditioning in patients with Alzheimer's disease.

One of the primary features of Alzheimer's disease (AD) is a disorder of memory. Although considerable effort has been devoted to characterizing this memory disorder, simple forms of memory such as classical (Pavlovian) conditioning have not been studied. The prevailing view has been that these simple forms of memory are not affected in AD. These forms of memory, however, may be of particular interest because they are beginning to be well understood at the neurobiological level. Because of this, when memory disorders are detected, it may be possible to specify their neurobiological substrate. We now report that classical conditioning of the eyeblink response is disrupted in AD patients compared to age-matched controls. This deficit in conditioning is not due to nonassociative factors such as changes in sensitivity to stimuli or disruption of the motor response. The results are considered in terms of using simple forms of memory to help generate hypotheses regarding the neurobiology of age-related memory disorders.

Aged↗
PubMedDate not supplied

Perinephric hemorrhage in autosomal dominant polycystic kidney disease: CT and MR findings.

Perinephric hemorrhage is a rare complication of autosomal dominant polycystic kidney disease (ADPKD). Of 66 patients in our series, it occurred in two (3%) and their clinical and radiologic findings are described. Computed tomography accurately delineated both hematomas and revealed an underlying ruptured hemorrhagic renal cyst in one patient. Computed tomography did not show the cause of hemorrhage in the other patient, but magnetic resonance (MR) imaging detected an underlying hemorrhagic cyst. Perinephric hemorrhage in ADPKD probably results from rupture of hemorrhagic renal cysts into the perinephric space. Computed tomography is the optimal method for its evaluation. However, MR may supplement CT findings since it detects more hemorrhagic cysts than CT and helps distinguish them from carcinomas. Perinephric hemorrhage in ADPKD can usually be managed conservatively.

Hemorrhage↗
PubMedDate not supplied

Unilateral renal cystic disease: CT findings.

Unilateral renal cystic disease (URCD) is characterized by replacement of most of one kidney by multiple cysts scattered diffusely throughout the parenchyma without the formation of a distinct, encapsulated renal mass. There are no cysts in the opposite kidney or liver. The condition is nonfamilial and does not cause renal functional impairment. We describe the clinical and radiologic findings in two patients with URCD and discuss how the disorder usually can be distinguished from other renal cystic diseases using CT. Absence of a family history of renal cystic disease and the normality of the other kidney help distinguish URCD from autosomal dominant polycystic kidney disease. The diffuse nature of the cysts in URCD and the absence of a distinct encapsulated renal mass help distinguish URCD from cystic renal neoplasms.

Adolescent↗
PubMedDate not supplied

Computed tomography of renal abscesses complicating medullary sponge kidney.

Although urinary tract infection occurs in approximately one-third of symptomatic patients with medullary sponge kidney (MSK), renal abscess is a rare complication of the disorder. We describe two patients with MSK complicated by renal abscesses that were diagnosed by CT. The diagnosis of renal abscess should be suspected in patients with MSK and acute pyelonephritis who do not respond to appropriate antibiotic therapy, and renal CT should be done. Computed tomography may show large abscesses that require percutaneous or open surgical drainage or small abscesses that require prolonged high dose antibiotic therapy.

Abscess↗