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Biomedical subjects

E Lenz

Publications and source records attributed to E Lenz.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Reactions of tumorous urinary bladders following local and systemic therapy with cytostatic drugs].

In 22 patients with bladder cancer after local chemotherapy and 13 patients after systemic chemotherapy, respectively, multiple biopsy specimens were examined histologically. Manifold hyperplastic, inflammatory, dysplastic, metaplastic and toxic alterations on the urothel, tumor cells and the lamina propria were found. This wide spectrum is the consequence of various etiological factors. On such treated cancer bladders the therapy-, age- and TuR-conditioned pathomorphological findings are running up with the known panurothelial reactions of a primary tumor in the urinary tract. We have classified the occurrence of multiple single cell necroses within the tumors as obligatory therapeutic effects. The granulomatous and degenerative stromal findings be conditioned by the therapy, if they are localized safely outside the area of previous TuR. The other reactive hyper- and dysplastic reactions be conditioned facultatively by the therapy.

Administration, Intravesical↗
PubMed1985

Digoxin specific antibody (Fab) fragments in 34 cases of severe digitalis intoxication.

34 patients aged between 2 and 80 years were treated with digoxin specific antibody (Fab) fragments for severe digitalis poisoning. In 27 cases, the glycoside was taken with suicidal intent; in 3 cases accidentally and 4 were iatrogenic. The following criteria were considered to be indications for use of Fab fragments: the appearance of life-threatening arrhythmias such as high-grade atrioventricular conduction disorders (grade 2 and 3 A-V block), multifocal ectopic beats, ventricular tachycardia, and relapsing ventricular fibrillation. Serum digoxin concentrations were between 3.4 and 29ng/ml before the start of treatment. Between 240 and 800mg of Fab were administered; the majority of patients received 480mg. Regression of arrhythmias was seen between 0.5 and 8 hours after Fab infusion. There was a rapid fall in the free digoxin in the serum to concentrations that were no longer measurable and a marked rise in bound digoxin with a simultaneous increase of excretion of bound digoxin in the urine. Fab therapy is considered to be a major advance in the treatment of severe, previously fatal, glycoside poisoning. No notable side effects or allergic reactions were observed.

Adolescent↗