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Biomedical subjects

E Lengyel

Publications and source records attributed to E Lengyel.

At least 55 records · Page 3Linked to original sources
PubMed1983

Free and complexed anti-lipoprotein antibodies in vascular diseases.

The cell-mediated immune response against low density lipoproteins (LDL) was demonstrated by the migration inhibition test in patients with various vascular diseases. Anti-high density lipoprotein2 (HDL2) cellular immune response was found only in a few patients. LDL and HDL2 binding factors were detected in about 50% of coronary patients. No significant difference in their occurrence was found between the normolipidemic and hyperlipidemic patients nor between patients with hyperlipidemia type II/b and type IV. On the assumption that lipoproteins may act as auto-antigens by forming immune complexes, the presence of anti-LDL and anti-HDL2 activity was investigated in circulating immune complexes obtained by polyethylene glycol (PEG) precipitation from the sera of coronary patients and controls. Using an ELISA technique, PEG-precipitable anti-LDL activity was detected in 23, 11 and 18% of cases with myocardial infarction, angina pectoris and healthy old subjects, respectively. In the immune complexes obtained from the sera of the healthy young donors no anti-LDL activity was found. Anti-HDL2 activity in the immune complexes was demonstrated only in a few cases from among the patients and elderly persons we investigated.

Adult↗
PubMed1981

[Polyarthrosis of the hand (author's transl)].

The polyarthrosis of the hand is a typical disease of the old age. Its banal form is more frequent in women, its erosive type in men. It can be demonstrated not only on the interphalangeal joints but on the metacarpophalangeal joints as well. The degenerative process of the basal-joints of the first ray of the hand is often seen in polyarthrosis. Most frequently diagnostic problems are caused by the erosive arthrosis however first of all polyarthrosis has to be differentiated from the p.c.p.

Aged↗
PubMed1980

[Arthrosis of the first foot segment in aged patients (author's transl)].

Basing on x-ray and clinical examinations, the authors report on the incidence, distribution according to sex and age, and lateral localisation of arthrosis occurring in the first segment of the foot. The bilateral type of arthrosis mostly occurs as a result of hallux valgus and is seen in women. Furthermore, degnerative changes and structural modifications of the dislocated sesamoids are also frequent. Arthrosis associated with hallux rigidus is a degenerative process mainly found in men, which is exclusively unilateral. This degenerative process shows the classical clinical and x-ray signs pertaining to arthrosis

Age Factors↗
PubMed1980

[Lipoprotein examination in old hyperlipemic persons (author's transl)].

The fluorescence and thiobarbituric acid reaction of isolated beta lipoprotein (beta-LP) and alpha lipoprotein (alpha-LP) have been studied in young, old, and old hyperlipemic persons. Specific fluorescence showed no significant difference in the beta-LP of young and old individuals. However, the difference was signficant in the A:F 380:450 fluorescence (A= activation wavelength, F = fluorescence or emission wavelength) of the alpha-LP. On the effect of autooxidation the alpha-LP showed a significant increase in both the A:F 380:450 and the A:F 410:470 fluorescence. Absorption at 530 nm has been studied by the thiobarbituric acid (TBA) reaction. The malondialdehyde (MDA) content has been given as microgram/mg on the basis of the curve obtained by the known quantity of MDA. The MDA content of beta-LP in the young and old groups was less increased as compared to the substantial increase of alpha-LP. As opposed to results obtained in senile persons MDA increase of alpha-LP has been significant in old hyperlipemic individuals. In addition to the absorption peak at 530 nm, characteristic for MDA, a peak at 450 nm has been obtained by TBA. A yellow-brown substance associated with hyperlipemia did appear mainly in the protein fraction isolated from alpha-LP and has been named protein III. During oxidation in hydrochloric acid a yellow-brown substance appeared from protein III fraction and became unsoluble and dark brown in hyperlipemic persons. The substance was considered as a precursor of the atherofluorescent component (AFC) present in atherosclerotic aortas. The reaction in the alpha-LP, and particularly in its protein component, with MDA (originating from peroxidezed unsaturated fatty acids) leads to complexes which are, assumably, precursors of atheromatous lipid and calcium plaques.

Adolescent↗
PubMed1980

[Results of orthopedic and radiological investigations on the knee joint of old age patients (author's transl)].

Orthopedic and radiological investigations were performed on the knee joint of 200 old age patients. The majority of them had no or minute signs, and were free of symptoms. The X-ray characteristics of the degenerative changes of the old age patient's knee joints, and their relationship with the clinical findings are discussed too. The authors point to the relevance of prearthritic conditions in the pathogenesis of those serious osteo-arthritic changes, which become evident in advanced ages.

Aged↗
PubMed1979

[Calcification of the ligament. ant. of the spina (disease of Forestier) (author's transl)].

On the basis of the examination on a rich old-age patient material it may be established that. 1. Radiomorphologically the Forestier's disease essentially differs from the banal spondylosis. 2. Age is of particular importance in its genesis -- it is primarily a disease of old age men. 3. It is localized for the most part on the dorsal vertebral part. 4. As compared to the multiple radiomorphological signs clinical symptoms are, in general, neglectable. 5. Additional search for the relationship with diabetic metabolic disturbances in gerontological patients seems advisable.

Age Factors↗
PubMed1979

Gerontological aspects of degenerative changes of the shoulder-joint. (Radiological and clinical studies).

In a series of radiological studies of both shoulder joint of 505 aged persons considering themselves healthy, the authors have systematized and statistically analysed the changes detected. Based on an increasing frequency as a function of age, on the identical ratio of occurrence by sexes and sides, on simultaneous occurrence, and on the identity of bilateral phenomena, the authors interpret these radiological changes as the consequence of a primary degenerative process. In the course of detailed clinical examinations and tests made in 100 cases taken at random, the authors have found no evaluable number and degree of limitations of motion, nor any evaluable difference in respect of the right and left shoulder joint of males and females.

Aged↗
PubMed1979

[Prevention of suture insufficiency using seromuscular gastric wall patch].

Seromuscular patches were prepared from the wall of the resected stomach of 20 dogs. The patches were used in the form of allogeneic and autologous grafts fixed with Histoacryl adhesive to cover gastric and intestinal sutures and gastric perforations. The aim was a hermetic closure of the wound and the prevention of suture insufficiency. In the 7 to 90 days follow-up period a perfect organization was observed in all the cases. On the basis of the favourable experimental results the clinical application of autologous seromuscular patches is suggested.

Animals↗
PubMed1979

[Covering the resected surface of parenchymatous organs with histoacryl-N-blue tissue adhesive and a seromuscular patch from the gastric wall].

Seromuscular patches were prepared from the gastric wall of 20 experimental dogs and used in the form of autologous or allogenic transplants for the covering of the resection surface of parenchymal organs (liver, spleen, pancreas). The patches were fixed by means of the tissue adhesive Histoacryl-N-Blue; the aim was to achieve haemostasis and to prevent running of the secretion. In the 1 to 90 days follow-up period the patches completely organized and in none of the cases did haemorrhage occur. On the basis of the good experimental results the authors suggest the possibility of the clinical application of autologous patches.

Animals↗
PubMed1978

Gerontological aspects of hyperostosis frontalis interna.

Authors discuss hyperostosis frontalis interna observed in a large number of aged persons, on the basis of age and sex distribution as well as its clinical and roentgenomorphological analysis. In various forms of the ossification of the frontal bone no significant difference was found between the localisation of hyperostosis and the clinical symptoms. On other hand, there is a direct correlation between the extension and severity of hyperostosis and the frequency of occurence of the associated symptoms (obesity, hypertension). They found the aetiological classification more adequate than the morphological categorization of Moore. Their cases are discussed 1. as partial phenomenon of the Morgagni's syndrome; 2. as independent alteration, showing no other symptoms; 3. as transitionary forms inserted between the two groups mentioned above. They discuss also the question of senile, compensatory hyperostosis frontalis interna. On the basis of the study of a large autopsy material they support the opinion that there is a direct connection of this form with old age.

Aged↗
PubMed1978

Autoantibodies in aged individuals.

Authors determined in 282 individuals autoantibodies in 132 T and B lymphozytes. Theirs results were as follows: 1. The frequency of the presence of autoantibodies increases with age. 2. In the presence of autoantibodies the absolute T and B lymphocyte counts of aged persons markedly decrease; the absolute T and B lymphozyte counts of young adult people do not change by existing autoantibodies. 3. There is a significant difference between the absolute T cell counts of aged and young adult age groups, both age-groups having autoantibodies. 4. Comparing the frequency of occurence of autoantibodies in aged healthy persons and in aged ones with cardiovascular changes and being in the habit of smoking and consuming alcohole, respectively, a significant difference could be demonstrated; in the latter group the frequency was much higher.

Age Factors↗
PubMed1976

[The Paget's disease--a gerontological study (author's transl)].

Authors found Paget's disease in cases among 1500 patients who considered themselves as healthy. They established their diagnosis on the basis of radiological and laboratory examinations. The incidence rate of Paget's disease was 0,7%, however it must be more frequent in the old groups. The familiar incidence of this illness is not frequent, thus it is rather intriguing that three persons i.e., 2 sisters and 1 brother is one family were found to have Paget's disease showing similar clinical and radiological symptoms. After three years the comparative examinations of two returning aged women showed a progress of Paget's disease. This manifested in exacerbation of osteopathy and increased the activity of the serum-alkaline-phosphatase. The cases of Paget's disease were reported by the authors because of the radiological interest, familiar incidence and the gerontological-geriatrical aspects.

Age Factors↗
PubMed1976

[Arthrosis of the first ray of the hand in geriatric patients (author's transl)].

The frequency of arthrosis in the first ray of the hand increases with the age of the patient, particularly in the saddle joint of the thumb and in the joint between the trapezoid bone and the navicular bone of the hand. The finding is frequently bilateral and is accompanied by kinesalgia, periarticular swelling and restricted movement. A relationship between arthrosis of the first ray of the hand and certain occupations can be assumed. While the arthrosis in the saddle joint of the thumb demonstrates the usual radiological symptoms of arthrosis, the sclerosing of the joint surfaces between the os naviculare and the ossa multangula is the most pronounced.

Age Factors↗