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Biomedical subjects

E Lengyel

Publications and source records attributed to E Lengyel.

At least 19 recordsLinked to original sources
PubMed1991

Lymphatic arteriopathy: damage to the wall of the canine femoral artery after lymphatic blockade.

The effect of lymph stasis on the histological, biochemical, and elastic properties of the femoral artery were studied after regional lymphatic blockade in 36 dogs. Dogs were sacrificed 4-21 days after operation. Histologic changes of the femoral arterial wall (interstitial edema, degeneration in the muscle layer or media, thickened adventitia with dilated lymph vessels, and fibrosis) developed after regional lymphatic blockade. Characteristic metabolic alterations of the arterial wall (anaerobic catabolism of carbohydrate, increased lactate and glycosamine content) accompanied the morphological changes. Distensibility of the femoral artery decreased and greater elastic stiffness developed after regional lymphatic blockade. These results in conjunction with other experimental and clinical data support the concept that insufficient lymphatic transport within the blood vessel wall may contribute to the genesis and progression of arteriopathies.

Animals↗
PubMed1985

Occurrence of anti-low density lipoprotein antibodies and circulating immune complexes in aged subjects.

The incidence of circulating immune complexes, anti-low density lipoprotein (LDL) autoantibodies and the anti-LDL activity of immune complexes was studied in healthy young and aged controls and in patients with vascular diseases. Circulating immune complexes (CIC) frequently occurred both in the young or old patient groups and in the aged healthy control groups, whereas they could not be found in the young controls. Marked differences were found in the incidence of anti-LDL antibodies between the groups tested. In both young and aged control groups such antibodies were very rarely observed (4-5%). In contrast anti-LDL antibodies were present in 35-45% in the aged, or young patients. Similarly, no anti-LDL activity was found in CIC of the controls, whereas in the patients with vascular diseases a significant CIC-associated anti-LDL activity was detected. These results suggest that the presence of anti-LDL antibodies are associated with the arteriosclerotic manifestations, while that of circulating immune complexes is connected by the ageing process itself.

Adult↗
PubMed1981

[Polyarthrosis of the hand (author's transl)].

The polyarthrosis of the hand is a typical disease of the old age. Its banal form is more frequent in women, its erosive type in men. It can be demonstrated not only on the interphalangeal joints but on the metacarpophalangeal joints as well. The degenerative process of the basal-joints of the first ray of the hand is often seen in polyarthrosis. Most frequently diagnostic problems are caused by the erosive arthrosis however first of all polyarthrosis has to be differentiated from the p.c.p.

Aged↗
PubMed1980

[Lipoprotein examination in old hyperlipemic persons (author's transl)].

The fluorescence and thiobarbituric acid reaction of isolated beta lipoprotein (beta-LP) and alpha lipoprotein (alpha-LP) have been studied in young, old, and old hyperlipemic persons. Specific fluorescence showed no significant difference in the beta-LP of young and old individuals. However, the difference was signficant in the A:F 380:450 fluorescence (A= activation wavelength, F = fluorescence or emission wavelength) of the alpha-LP. On the effect of autooxidation the alpha-LP showed a significant increase in both the A:F 380:450 and the A:F 410:470 fluorescence. Absorption at 530 nm has been studied by the thiobarbituric acid (TBA) reaction. The malondialdehyde (MDA) content has been given as microgram/mg on the basis of the curve obtained by the known quantity of MDA. The MDA content of beta-LP in the young and old groups was less increased as compared to the substantial increase of alpha-LP. As opposed to results obtained in senile persons MDA increase of alpha-LP has been significant in old hyperlipemic individuals. In addition to the absorption peak at 530 nm, characteristic for MDA, a peak at 450 nm has been obtained by TBA. A yellow-brown substance associated with hyperlipemia did appear mainly in the protein fraction isolated from alpha-LP and has been named protein III. During oxidation in hydrochloric acid a yellow-brown substance appeared from protein III fraction and became unsoluble and dark brown in hyperlipemic persons. The substance was considered as a precursor of the atherofluorescent component (AFC) present in atherosclerotic aortas. The reaction in the alpha-LP, and particularly in its protein component, with MDA (originating from peroxidezed unsaturated fatty acids) leads to complexes which are, assumably, precursors of atheromatous lipid and calcium plaques.

Adolescent↗
PubMed1980

[Results of orthopedic and radiological investigations on the knee joint of old age patients (author's transl)].

Orthopedic and radiological investigations were performed on the knee joint of 200 old age patients. The majority of them had no or minute signs, and were free of symptoms. The X-ray characteristics of the degenerative changes of the old age patient's knee joints, and their relationship with the clinical findings are discussed too. The authors point to the relevance of prearthritic conditions in the pathogenesis of those serious osteo-arthritic changes, which become evident in advanced ages.

Aged↗
PubMed1979

[Calcification of the ligament. ant. of the spina (disease of Forestier) (author's transl)].

On the basis of the examination on a rich old-age patient material it may be established that. 1. Radiomorphologically the Forestier's disease essentially differs from the banal spondylosis. 2. Age is of particular importance in its genesis -- it is primarily a disease of old age men. 3. It is localized for the most part on the dorsal vertebral part. 4. As compared to the multiple radiomorphological signs clinical symptoms are, in general, neglectable. 5. Additional search for the relationship with diabetic metabolic disturbances in gerontological patients seems advisable.

Age Factors↗
PubMed1979

Gerontological aspects of degenerative changes of the shoulder-joint. (Radiological and clinical studies).

In a series of radiological studies of both shoulder joint of 505 aged persons considering themselves healthy, the authors have systematized and statistically analysed the changes detected. Based on an increasing frequency as a function of age, on the identical ratio of occurrence by sexes and sides, on simultaneous occurrence, and on the identity of bilateral phenomena, the authors interpret these radiological changes as the consequence of a primary degenerative process. In the course of detailed clinical examinations and tests made in 100 cases taken at random, the authors have found no evaluable number and degree of limitations of motion, nor any evaluable difference in respect of the right and left shoulder joint of males and females.

Aged↗
PubMed1979

[Prevention of suture insufficiency using seromuscular gastric wall patch].

Seromuscular patches were prepared from the wall of the resected stomach of 20 dogs. The patches were used in the form of allogeneic and autologous grafts fixed with Histoacryl adhesive to cover gastric and intestinal sutures and gastric perforations. The aim was a hermetic closure of the wound and the prevention of suture insufficiency. In the 7 to 90 days follow-up period a perfect organization was observed in all the cases. On the basis of the favourable experimental results the clinical application of autologous seromuscular patches is suggested.

Animals↗
PubMed1979

[Covering the resected surface of parenchymatous organs with histoacryl-N-blue tissue adhesive and a seromuscular patch from the gastric wall].

Seromuscular patches were prepared from the gastric wall of 20 experimental dogs and used in the form of autologous or allogenic transplants for the covering of the resection surface of parenchymal organs (liver, spleen, pancreas). The patches were fixed by means of the tissue adhesive Histoacryl-N-Blue; the aim was to achieve haemostasis and to prevent running of the secretion. In the 1 to 90 days follow-up period the patches completely organized and in none of the cases did haemorrhage occur. On the basis of the good experimental results the authors suggest the possibility of the clinical application of autologous patches.

Animals↗
PubMed1978

Gerontological aspects of hyperostosis frontalis interna.

Authors discuss hyperostosis frontalis interna observed in a large number of aged persons, on the basis of age and sex distribution as well as its clinical and roentgenomorphological analysis. In various forms of the ossification of the frontal bone no significant difference was found between the localisation of hyperostosis and the clinical symptoms. On other hand, there is a direct correlation between the extension and severity of hyperostosis and the frequency of occurence of the associated symptoms (obesity, hypertension). They found the aetiological classification more adequate than the morphological categorization of Moore. Their cases are discussed 1. as partial phenomenon of the Morgagni's syndrome; 2. as independent alteration, showing no other symptoms; 3. as transitionary forms inserted between the two groups mentioned above. They discuss also the question of senile, compensatory hyperostosis frontalis interna. On the basis of the study of a large autopsy material they support the opinion that there is a direct connection of this form with old age.

Aged↗
PubMed1978

Autoantibodies in aged individuals.

Authors determined in 282 individuals autoantibodies in 132 T and B lymphozytes. Theirs results were as follows: 1. The frequency of the presence of autoantibodies increases with age. 2. In the presence of autoantibodies the absolute T and B lymphocyte counts of aged persons markedly decrease; the absolute T and B lymphozyte counts of young adult people do not change by existing autoantibodies. 3. There is a significant difference between the absolute T cell counts of aged and young adult age groups, both age-groups having autoantibodies. 4. Comparing the frequency of occurence of autoantibodies in aged healthy persons and in aged ones with cardiovascular changes and being in the habit of smoking and consuming alcohole, respectively, a significant difference could be demonstrated; in the latter group the frequency was much higher.

Age Factors↗
PubMed1976

[The Paget's disease--a gerontological study (author's transl)].

Authors found Paget's disease in cases among 1500 patients who considered themselves as healthy. They established their diagnosis on the basis of radiological and laboratory examinations. The incidence rate of Paget's disease was 0,7%, however it must be more frequent in the old groups. The familiar incidence of this illness is not frequent, thus it is rather intriguing that three persons i.e., 2 sisters and 1 brother is one family were found to have Paget's disease showing similar clinical and radiological symptoms. After three years the comparative examinations of two returning aged women showed a progress of Paget's disease. This manifested in exacerbation of osteopathy and increased the activity of the serum-alkaline-phosphatase. The cases of Paget's disease were reported by the authors because of the radiological interest, familiar incidence and the gerontological-geriatrical aspects.

Age Factors↗