Search PubMedSearch

Biomedical subjects

E Lencioni

Publications and source records attributed to E Lencioni.

At least 19 recordsLinked to original sources

Approach to the sterilization with gamma rays of a drug. Note I: Treatment technique and effects at zero time.

Authors, considering a possible use of the sterilizing treatment with gamma rays for the productive process of a drug, performed a series of practical treatment tests. To this purpose, they used a single molecule, stable in time and with an easy analytical approach. The examined active principle is the injectable salt of acetylcarnitine chloride. For tests, they used irradiating doses by 2.5-5.0-7.5 Mrads in order to point out the process possible effects. The treatment, even at highest dosages, did not show damages to the molecule that could prevent from going on with the investigation.

Acetylcarnitine

[Densitometric control of the degradation products of vitamin B1 and calculating activation factors].

The authors perfect a TLC method with densitometric detection for the determination of vitamin B1 in the presence of its hydrolytic and oxidation products. The decomposition process and the proportions of products formed in the ampoules under different conditions of temperature/time treatment are also investigated and the activation factors (z and FO) of thiamine thermical decomposition, for their application in sterilization processes.

Densitometry